Results 61 to 70 of about 13,475,824 (303)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Application progress on mobile health in drug management of patients with chronic diseases

Huli yanjiu, 2020
This paper analyzed and summarized relevant researches on the application of mobile health in drug management of patients with chronic diseases，such as its origin and development， application methods，effect evaluation，patients' attitude towards it and ...
PENG Yihang, XIE Liling
doaj  

Combination Drug Therapy for the Management of Alzheimer’s Disease

International Journal of Molecular Sciences, 2020
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Even though the number of AD patients is rapidly growing, there is no effective treatment for this neurodegenerative disorder.
M. Kabir, Md Elias Uddin, A. Mamun, P. Jeandet, L. Aleya, Rasha A Mansouri, G. Ashraf, Bijo Mathew, M. Bin-Jumah, Mohamed M. Abdel-Daim   +9 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines

Signal Transduction and Targeted Therapy
The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. The integration of novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering ...
Wenjing Xiao, Wenjie Jiang, Zheng Chen, Yu Huang, Junyi Mao, Wei Zheng, Yonghe Hu, Jianyou Shi   +7 more
semanticscholar   +1 more source

Managing drug resistant tuberculosis [PDF]

BMJ, 2008
#### Summary points Antituberculosis drug resistance is increasing both in the United Kingdom and internationally.1 2 It has come to greater public attention with the emergence of extensively drug resistant tuberculosis (box 1) in South Africa, where an outbreak proved rapidly fatal among people with advanced HIV infection.3 In this article we review ...
Grant, Alison, Gothard, Philip, Thwaites, Guy   +2 more
openaire   +4 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Analysis of Health Literacy level and its Influencing Factors among the Elderly in a Certain City of China [PDF]

SHS Web of Conferences
Objective To understand the health literacy level and its influencing factors of elderly in Guangzhou, so as to provide scientific evidence for formulating effective intervention measures and policies.
Guo Yintong, Li Zhuangwei, Song Hui, Jiang Dan, Dong Jian   +4 more
doaj   +1 more source

Management of drug supply chain information based on “artificial intelligence + vendor managed inventory” in China: perspective based on a case study

Frontiers in Pharmacology
Objectives To employ a drug supply chain information system to optimize drug management practices, reducing costs and improving efficiency in financial and asset management.
Jianwen Shen, Fengjiao Bu, Zhengqiang Ye, Min Zhang, Q. Ma, Jingchao Yan, Taomin Huang   +6 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source