Results 1 to 10 of about 8,600,526 (387)

online quantitative analysis, online process mass spectrometer, quadrupole mass spectrometer [PDF]

Zhipu Xuebao, 2023
As of October 2022, the United Nations Office on Drugs and Crime (UNODC) Early Warning Advisory (EWA) has monitored over 1 150 new psychoactive substances (NPS) that had appeared in 137 countries and territories, including 76 substances that were ...
LIU Cui-mei1, HUA Zhen-dong1, HUANG Yu2, HU Wen2, ZHAO Xia3, JIA Wei1   +5 more
doaj   +1 more source

Impact of COVID-19 on drug markets, use, harms and drug services in Europe

Journal of Geography, Politics and Society, 2022
Since early 2020, the COVID-19 pandemic has had a dramatic impact on the way we live, with European countries having to introduce unprecedented measures to protect public health. As with all areas of life, drug consumption, related harms and drug markets
Alessandro Pirona , João Matias , Linda Montanari , Katerina Skarupova , Marica Ferri , Isabelle Giraudon , Jane Mounteney , Sandrine Sleiman , Katarzyna Natoniewska , Bruno Guarita , Liesbeth Vandam , Tim Surmont , Paul Griffiths   +12 more
doaj   +1 more source

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Clinical pharmacology and therapy, 2021
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections.
S. Wicha, A. Märtson, E. Nielsen, B. Koch, L. Friberg, J. Alffenaar, Iris K. Minichmayr   +6 more
semanticscholar   +1 more source

Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

Therapeutic Drug Monitoring, 2021
When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the potential for a more personalized dosing has led to development of methods to estimate MPA area under ...
S. Bergan, M. Brunet, D. Hesselink, K. Johnson-Davis, P. Kunicki, F. Lemaitre, P. Marquet, M. Molinaro, Ofelia Noceti, S. Pattanaik, T. Pawiński, C. Seger, M. Shipkova, J. Swen, T. van Gelder, R. Venkataramanan, E. Wieland, J. Woillard, Tom C. Zwart, M. Barten, K. Budde, M. Dieterlen, L. Elens, V. Haufroid, S. Masuda, O. Millán, T. Mizuno, D. Moes, M. Oellerich, N. Picard, Linda Salzmann, B. Tönshoff, R. V. van Schaik, N. T. Vethe, A. Vinks, P. Wallemacq, A. Åsberg, L. Langman   +37 more
semanticscholar   +1 more source

A Simple UPLC/MS-MS Method for Simultaneous Determination of Lenvatinib and Telmisartan in Rat Plasma, and Its Application to Pharmacokinetic Drug-Drug Interaction Study

Molecules, 2022
Lenvatinib is a multi-targeted tyrosine kinase inhibitor that inhibits tumor angiogenesis, but hypertension is the most common adverse reaction. Telmisartan is an angiotensin receptor blocker used to treat hypertension.
Yanjun Cui, Ying Li, Xiao Li, Liju Fan, Xueru He, Yuhao Fu, Zhanjun Dong   +6 more
doaj   +1 more source

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and ...
S. W. Syversen, G. Goll, K. Jørgensen, Ø. Sandanger, J. Sexton, Inge Christoffer Olsen, J. Gehin, D. Warren, M. K. Brun, R. Klaasen, L. Karlsen, G. Noraberg, C. Zettel, M. Ljoså, A. Haugen, Rune Johan Njålla, T. J. Bruun, K. A. Seeberg, B. Michelsen, E. K. Strand, S. Skorpe, I. Blomgren, Y. Bragnes, C. Dotterud, T. Thune, C. Ystrøm, R. Torp, P. Mielnik, C. Mork, T. Kvien, J. Jahnsen, N. Bolstad, E. Haavardsholm   +32 more
semanticscholar   +1 more source

QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats

Pharmaceutical Biology, 2022
Context Atorvastatin (ATV) and QiShenYiQi pills (QSYQ), a Chinese patent medicine, are often co-prescribed to Chinese cardiovascular patients. The effects of QSYQ on the pharmacokinetics of ATV have not been studied.
Congyang Ding, Yajing Li, Xiao Li, Lu Meng, Ran Fu, Xiaonan Wang, Ying Li, Yinling Ma, Zhanjun Dong   +8 more
doaj   +1 more source

Development of UPLC-MS/MS Method to Study the Pharmacokinetic Interaction between Sorafenib and Dapagliflozin in Rats

Molecules, 2022
Sorafenib (SOR), an inhibitor of multiple kinases, is a classic targeted drug for advanced hepatocellular carcinoma (HCC) which often coexists with type 2 diabetes mellitus (T2DM). Dapagliflozin (DAPA), a sodium–glucose cotransporter-2 inhibitor (SGLT2i),
Xueru He, Ying Li, Yinling Ma, Yuhao Fu, Xuejiao Xun, Yanjun Cui, Zhanjun Dong   +6 more
doaj   +1 more source

Pharmacokinetic Interactions between Canagliflozin and Sorafenib or Lenvatinib in Rats

Molecules, 2022
Hepatocellular carcinoma (HCC) and type 2 diabetes mellitus (T2DM) are common clinical conditions, and T2DM is an independent risk factor for HCC. Sorafenib and lenvatinib, two multi-targeted tyrosine kinase inhibitors, are first-line therapies for ...
Yanjun Cui, Ying Li, Caihui Guo, Yajing Li, Yinling Ma, Zhanjun Dong   +5 more
doaj   +1 more source

Determination of Osimertinib, Aumolertinib, and Furmonertinib in Human Plasma for Therapeutic Drug Monitoring by UPLC-MS/MS

Molecules, 2022
The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), osimertinib, aumolertinib, and furmonertinib represent a new treatment option for patients with EGFR p.Thr790 Met (T790 M)-mutated non-small cell lung cancer ...
Ying Li, Lu Meng, Yinling Ma, Yajing Li, Xiaoqing Xing, Caihui Guo, Zhanjun Dong   +6 more
doaj   +1 more source