Results 41 to 50 of about 9,044,537 (408)

The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib

Frontiers in Pharmacology, 2020
Pharmacometric methods have hugely benefited from progress in analytical and computer sciences during the past decades, and play nowadays a central role in the clinical development of new medicinal drugs.
T. Buclin, Yann Thoma, Nicolas Widmer, P. André, M. Guidi, C. Csajka, L. Decosterd   +6 more
semanticscholar   +1 more source

Liquid Chromatography/Tandem Mass Spectrometry for the Simultaneous Determination of Alverine and its Metabolite, Monohydroxy Alverine, in Human Plasma: Application to a Pharmacokinetic Study

E-Journal of Chemistry, 2011
A rapid and sensitive LC-MS-MS method for the determination of alverine (ALV) and its major metabolite, monohydroxy alverine (MHA), in human plasma using imipramine as an internal standard was developed and validated. The analytes were extracted from 0.5
Rahul C. Gavhane, Ketan K. Nerurkar, Ashok M. Kalamkar, Mitesh R. Patil, Satish G. Pingale, Prafullakumar Kulkarni   +5 more
doaj   +1 more source

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report

Therapeutic Drug Monitoring, 2019
: Ten years ago, a consensus report on the optimization of tacrolimus was published in this journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicity (IATDMCT)
M. Brunet, T. van Gelder, A. Åsberg, V. Haufroid, D. Hesselink, L. Langman, F. Lemaitre, P. Marquet, C. Seger, M. Shipkova, A. Vinks, P. Wallemacq, E. Wieland, J. Woillard, M. Barten, K. Budde, H. Colom, M. Dieterlen, L. Elens, K. Johnson-Davis, P. Kunicki, I. Macphee, S. Masuda, B. Mathew, O. Millán, T. Mizuno, D. Moes, C. Monchaud, Ofelia Noceti, T. Pawiński, N. Picard, R. V. van Schaik, C. Sommerer, N. T. Vethe, B. D. de Winter, U. Christians, S. Bergan   +36 more
semanticscholar   +1 more source

Optimal Management of the Public and Patients by Pharmacists in the Era of COVID-19: An Evidence-Based Review and Practical Recommendations

Frontiers in Public Health, 2022
Purpose: Currently, managing the public and patients during the COVID-19 pandemic is constituting a health care challenge worldwide. Patient-oriented management is of crucial importance to promote emergency preparedness and response.
Zaiwei Song, Zaiwei Song, Zaiwei Song, Yang Hu, Yang Hu, Yang Hu, Yang Hu, Zhenyu Ren, Zhenyu Ren, Zhenyu Ren, Guanru Wang, Guanru Wang, Guanru Wang, Guanru Wang, Shuang Liu, Shuang Liu, Shuang Liu, Siqian Zheng, Siqian Zheng, Siqian Zheng, Li Yang, Li Yang, Li Yang, Rongsheng Zhao, Rongsheng Zhao, Rongsheng Zhao   +25 more
doaj   +1 more source

An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats

Molecules, 2018
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors.
Song-Tao Dong, Ying Li, Hao-Tian Yang, Yin Wu, Ya-Jing Li, Cong-Yang Ding, Lu Meng, Zhan-Jun Dong, Yuan Zhang   +8 more
doaj   +1 more source

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]

, 2018
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian, Cheung, Wing, Coello, Neva, Franz, David N, French, Jacqueline A, Grosch, Kai, Kohrman, Michael H, Lawson, John A, Milh, Mathieu, Voi, Maurizio, Wiemer-Kruel, Adelheid, Wong, Michael, Yapici, Zuhal   +12 more
core   +2 more sources

Comparative study on main compounds and hypoglycemic effects of dispensing granules of Coptidis Rhizoma and Scutellaria–Coptis herb couple with traditional decoction

Chinese Medicine, 2023
Background The clinical applications of dispensing granules (DG) have increased dramatically. However, it is controversial whether the DG has the same quality and efficacy compared with traditional decoction (TD).
Huanhuan Yu, Huilan Tang, Guang Hu, Zhu Chen, Mudan Guo, Bo Jiang, En Zhang, Changhua Hu   +7 more
doaj   +1 more source

Authentication test of seasoning food materials made from turmeric using real-time PCR

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2023
The authentication test for spices made from turmeric using real-time. This study aimed to determine whether the spice ingredients claimed to be made from turmeric actually contain turmeric, as asserted by the product.
Alfi Sophian, Ratna Purwaningsih
doaj   +1 more source

Recreational Use of Nitrous Oxide – a Growing Concern in Europe

Emerging Trends in Drugs, Addictions, and Health
Introduction: Nitrous oxide, commonly known as laughing gas, is used medically as an analgesic and anaesthetic. It has been used recreationally for its brief euphoric effects for over 200 years, however, in the last decade, there has been a large ...
J. De Morais, L. Van Aerts, M. Evans-Brown, A. Gallegos, R. Christie, R. Jorge, T. Néfau, G. Planchuelo, R. Sedefov, C. Victorri-Vigneau, R. Povilanskiene, K. Grasaasen, D.F.t. Palmqvis, D. Mongan, K. Killeen, A.O. Duarte, A.S. Santos   +16 more
doaj   +1 more source

From clinical application to cognitive enhancement: the example of methylphenidate [PDF]

, 2016
Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO, Cipolloni, Luigi, Frati, Paola, Kyriakou, Chrystalla, Zaami, Simona   +4 more
core   +1 more source