Results 41 to 50 of about 1,599,561 (306)
From clinical application to cognitive enhancement: the example of methylphenidate [PDF]
, 2016 Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO +4 more
core +1 more source
Bayesian data assimilation to support informed decision-making in individualized chemotherapy [PDF]
, 2020 An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes.
de Wiljes, Jana +4 more
core +2 more sources
Age Differences in Psychoactive Substance Abuse in Population of the Republic of Belarus
Central European Journal of Sport Sciences and Medicine, 2016 Background. The recent epidemiological studies conducted in Belarus point to a fall in the average age of registered drug abusers and in the age of drug use onset, an increasing proportion of injecting drugs, and addicted persons.
Vladimir Lelevich +3 more
doaj +1 more source
Liang you shipin ke-ji, 2021 To establish a method for the simultaneous determination of 15 mycotoxins in grains by ultra performance liquid chromatography tandem mass spectrometry (UPLC/MSMS).
LIU Xiao-xiao +6 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]
, 2018 ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian +12 more
core +2 more sources
Molecules, 2023 Ketamine analogues have been emerging in recent years and are causing severe health and social problems worldwide. Ketamine analogues use 2-phenyl-2-aminocyclohexanone as the basic structure and achieve physiological reactions similar to or even more ...
Yilei Fan +5 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study [PDF]
, 2020 ObjectiveThe United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices.
Hussain, Mustafa I +4 more
core
Frontiers in Pharmacology, 2022 Objective: With increasing numbers of biosimilars entering the market or in the approval pipeline in China, understanding the current awareness and attitudes of biosimilars still remains the first step to promote uptake.
Yang Hu +17 more
doaj +1 more source