Results 51 to 60 of about 2,524,657 (288)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Novel Strategies for the Formulation of Poorly Water-Soluble Drug Substances by Different Physical Modification Strategies with a Focus on Peroral Applications

Pharmaceuticals
The number of newly developed substances with poor water solubility continually increases. Therefore, specialized formulation strategies are required to overcome the low bioavailability often associated with this property.
Julian Quodbach, Eduard Preis, Frank Karkossa, Judith Winck, Jan Henrik Finke, Denise Steiner   +5 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

Beilstein Journal of Nanotechnology, 2019
Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer ...
Sebastian Pieper, Hannah Onafuye, Dennis Mulac, Jindrich Cinatl Jr., Mark N. Wass, Martin Michaelis, Klaus Langer   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Multicomponent organic nanoparticles for fluorescence studies in biological systems [PDF]

, 2012
The formation of dual-component organic nanoparticles by a modified emulsion-templated freeze-drying approach leads to aqueous nanosuspensions showing fluorescence (Förster) resonance energy transfer (FRET) from within a distribution of single ...
Tom O. McDonald, Rannard, Steven, Smith, Darren, O'Reilly, Rachel, Steve Rannard, O'Reilly, Rachel K.; id_orcid, Smith, Darren; id_orcid, O'Reilly, Rachel K., Andrew Owen, Patterson, Joseph, Owen, Andrew, Rannard, Steve, McDonald, Tom, See, Violaine, Darren Smith, Patterson, Joseph P., Marcello, Marco, Violaine See, Giardiello, Marco, McDonald, Tom O., Marco Marcello, Marco Giardiello, Philip Martin, Rachel K. O'Reilly, Martin, Philip, McDonald, Tom O.; id_orcid, Joseph P. Patterson   +26 more
core   +1 more source

Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors

Drug Delivery, 2023
Nano-based drug delivery systems hold significant promise for cancer therapies. Presently, the poor accumulation of drug-carrying nanoparticles in tumors has limited their success.
Mohammad Souri, Mohammad Kiani Shahvandi, Mohsen Chiani, Farshad Moradi Kashkooli, Ali Farhangi, Mohammad Reza Mehrabi, Arman Rahmim, Van M. Savage, M. Soltani   +8 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Gold nanoparticles explore cells: cellular uptake and their use as intracellular probes [PDF]

, 2014
Understanding uptake of nanomaterials by cells and their use for intracellular sensing is important for studying their interaction and toxicology as well as for obtaining new biological insight.
Septiadi, Dedy, Barker, Roger A., Huefner, Anna, Fragniere, Alexandra, Mahajan, Sumeet, Kuan, Wei-Li, Wilts, Bodo D., Patel, Imran I.   +7 more
core   +1 more source