Results 51 to 60 of about 3,896,424 (394)
Heliyon, 2023 We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic +2 more
doaj +1 more source
Understanding tissue morphology: model repurposing using the CoSMoS process [PDF]
, 2014 We present CoSMoS as a way of structuring thinking on how to reuse parts of an existing model and simulation in a new model and its implementation. CoSMoS provides a lens through which to consider, post-implementation, the assumptions made during the ...
Bown, James L. +4 more
core +3 more sources
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
International Journal of Molecular Sciences, 2022 Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many women of childbearing age. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology and pathophysiology are not comprehensively ...
H. Sadeghi +8 more
semanticscholar +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources
Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities
Frontiers in Pharmacology, 2023 Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America.
Exequiel O. J. Porta +2 more
semanticscholar +1 more source
ImmPort, toward repurposing of open access immunological assay data for translational and clinical research [PDF]
, 2018 Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging ...
Bhattacharya, Sanchita +12 more
core +2 more sources
Drug Repurposing in Parkinson’s Disease [PDF]
CNS Drugs, 2018 The development of an intervention to slow or halt disease progression remains the greatest unmet therapeutic need in Parkinson's disease. Given the number of failures of various novel interventions in disease-modifying clinical trials in combination with the ever-increasing costs and lengthy processes for drug development, attention is being turned to
Athauda, D, Foltynie, T
openaire +3 more sources
HGTDR: Advancing drug repurposing with heterogeneous graph transformers [PDF]
Bioinform.Motivation Drug repurposing is a viable solution for reducing the time and cost associated with drug development. However, thus far, the proposed drug repurposing approaches still need to meet expectations.
Ali Gharizadeh +4 more
semanticscholar +1 more source
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids
Protein & Cell, 2023 Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be addressed. Here, we established human CRC tumor-derived organoids that well represent both morphological and molecular ...
Yunuo Mao +9 more
semanticscholar +1 more source
Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. [PDF]
, 2019 ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing ...
Bushong, Trevor +8 more
core +2 more sources