Results 1 to 10 of about 2,311,261 (354)

Effects of Bedaquiline Combined with Fluoroquinolone and/or Clofazimine on QT Interval in Patients with Multidrug-Resistant Tuberculosis: a Retrospective Study

Microbiology Spectrum, 2023
With the application of bedaquiline (Bdq), the success rate of multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, the cardiac safety of the patients during treatment cannot be ignored. Hence, this study compared
Rong Li, Jin-Bao Ma, Hong Yang, Han Yang, Xin-Jun Yang, Yan-Qin Wu, Fei Ren   +6 more
doaj   +1 more source

A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections

Vaccines, 2023
Antibody Dependent Enhancement (ADE) of an infection has been of interest in the investigation of many viruses. It is associated with the severity of the infection.
Jyoti Sawant, Ajit Patil, Swarali Kurle
doaj   +1 more source

Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis

BMC Infectious Diseases, 2023
Background The World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57% globally. Although new drugs such as bedaquiline and linezolid is likely improve the treatment outcome, there
J-B Ma, L-C Zeng, F Ren, L-Y Dang, H Luo, Y-Q Wu, X-J Yang, R Li, H Yang, Y Xu   +9 more
doaj   +1 more source

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection [PDF]

, 2011
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Andrew, P W, Barer, M, Bonnet, M, Checchi, F, Fattorini, L, Jarosz, T, Meacci, F, Melzer, J, Niemann, S, Oggioni, M R, Orefici, G, Orrù, G, Pardini, M, Rinder, H, Rüsch-Gerdes, S, Varaine, F, Yesilkaya, H   +16 more
core   +14 more sources

Experimental Closed-Loop Control of Breast Cancer in Mice

Complexity, 2022
Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer.
Levente Kovács, Bence Czakó, Máté Siket, Tamás Ferenci, András Füredi, Balázs Gombos, Gergely Szakács, Dániel András Drexler   +7 more
doaj   +1 more source

Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes

mSystems, 2021
Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar   +10 more
doaj   +1 more source

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh, A Scalbert, AK Chavali, Andris Jankevics, BO Keller, C Bern, C Christin, CC HsuChen, D Kumar, David G. Watson, DS Wishart, E Cauchetier, E Fahy, F Chappuis, F Hong, FR Opperdoes, G Barratt, Graham H. Coombs, H Ogata, HC Maltezou, HJ Atherton, HP de Koning, HW Murray, J Alvar, J Trygg, J Vandesompele, JC Mottram, Jean-Claude Dujardin, JV Olsen, K Zhang, K Zhang, Kirstyn Brunker, KW Tintaya, M Basselin, M Basselin, M Rakotomanga, MA Basinger, MA Doyle, MA Kamleh, MA Kamleh, MB Eisen, MK Wassef, MZ Alam, N Mbongo, N Van Meirvenne, R Breitling, R Breitling, R Breitling, RA Scheltema, RA Scheltema, RA Scheltema, Rainer Breitling, Richard A. Scheltema, Ruben t'Kindt, S Rijal, S Sundar, Saskia Decuypere, Suman Rijal, T Laurent, T Naderer, Timothy G. Geary, VP Shah, W Windig, WB Dunn   +63 more
core   +11 more sources

Burden of malaria infection among individuals of varied blood groups in Kenya

Malaria Journal, 2022
Background The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans.
Redemptah Yeda, Charles Okudo, Eunice Owiti, Gladys Biwot, Cliff Momanyi, Winnie Korir, Thoya Mitsanze, Caroline Tegerei, Dennis Juma, Benjamin Opot, Edwin Mwakio, Gladys Chemwor, Raphael Okoth, Douglas O. Ochora, Agnes C. Cheruiyot, Amanda Roth, Hoseah M. Akala, Ben Andagalu   +17 more
doaj   +1 more source

The Role of Drug Resistance in Candida Inflammation and Fitness [PDF]

Microorganisms
Piatti G, Vitale A, Schito A, Penco S, Saverino D.   +4 more
europepmc   +2 more sources

malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication.

PLoS Medicine, 2017
Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts. Suboptimal responses to drugs and insecticides are both spreading geographically and
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
doaj   +1 more source