Results 1 to 10 of about 1,291,063 (266)

Mapping convergent regulators of melanoma drug resistance by PerturbFate. [PDF]

Nature
Xu Z, Lu Z, Ugurbil A, Abdulraouf A, Liao A, Zhang J, Zhou W, Cao J.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Challenges and advances in drug resistance and tolerance in cancer. [PDF]

J Exp Clin Cancer Res
Bivona TG, Yanai I, Calabrò F, Mechta-Grigoriou F, Corleone G, Di Martile M, Tocci A, Tocci P, Vaccarella S, Ferriero MC, Alimonti A, Ruppin E, Nisticò P, Bagnato A, Blandino G.   +14 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer. [PDF]

Cell Rep
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR, Grose RP.   +18 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identification of Specific LncRNA Markers in Severe Tuberculosis for Early Diagnosis

Infection and Drug Resistance
Siyu Yao,1,* Xiuxiu Ji,2,* Ruize Wang,1 Liping Pan,2 Qiuyue Liu1 1Department of Critical Care Medicine, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, People’s ...
Yao S, Ji X, Wang R, Pan L, Liu Q
doaj  

Distribution and Drug-Resistance Analysis of Uropathogens in Urinary Tract Infections. [PDF]

Can J Infect Dis Med Microbiol
Wu W, Wu Q, Zhong W, Han L.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Targeting metabolism to combat anticancer and antibacterial drug resistance. [PDF]

Trends Pharmacol Sci
Chung CH, Bhowmick R, Badenoch AJ, Arora HS, Chandrasekaran S.   +4 more
europepmc   +1 more source