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Drug resistance and combating drug resistance in cancer
Cancer is the second leading cause of death in the US. Current major treatments for cancer management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy.
Xuan Wang, Haiyun Zhang, Xiaozhuo Chen
semanticscholar +4 more sources
Abstract Chemotherapy fails to cure most cancer patients with advanced disease, particularly patients with the most common forms of solid tumors. The presence or development of resistance to anticancer agents is the major cause of this failure.
Giaccone, G., Pinedo, H.M.
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Targeting epigenetic regulators to overcome drug resistance in cancers
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting-xing Ma, Ting Yu
semanticscholar +1 more source
With the application of bedaquiline (Bdq), the success rate of multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, the cardiac safety of the patients during treatment cannot be ignored. Hence, this study compared
Rong Li+6 more
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Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera.
Yunjin Lee, Nicole Robbins, L. Cowen
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A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections
Antibody Dependent Enhancement (ADE) of an infection has been of interest in the investigation of many viruses. It is associated with the severity of the infection.
Jyoti Sawant, Ajit Patil, Swarali Kurle
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Ferroptosis in cancer therapy: a novel approach to reversing drug resistance
Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer ...
Chen Zhang+4 more
semanticscholar +1 more source
Drugging Drug Resistance [PDF]
Resistance to anticancer drugs is widely observed in vitro and in cancer patients, but its prevalence is too high to be solely explained by the acquisition of mutations. Sharma et al. (2010) now report that dynamic chromatin modifications may be an independent route to drug resistance in cancer cells that can be reversed by epigenetic drugs.
Anton Berns, Jan-Hermen Dannenberg
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