Results 1 to 10 of about 2,266,575 (311)
Microbiology Spectrum, 2023 With the application of bedaquiline (Bdq), the success rate of multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, the cardiac safety of the patients during treatment cannot be ignored. Hence, this study compared
Rong Li +6 more
doaj +1 more source
A Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections
Vaccines, 2023 Antibody Dependent Enhancement (ADE) of an infection has been of interest in the investigation of many viruses. It is associated with the severity of the infection.
Jyoti Sawant, Ajit Patil, Swarali Kurle
doaj +1 more source
BMC Infectious Diseases, 2023 Background The World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57% globally. Although new drugs such as bedaquiline and linezolid is likely improve the treatment outcome, there
J-B Ma +9 more
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Experimental Closed-Loop Control of Breast Cancer in Mice
Complexity, 2022 Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer.
Levente Kovács +7 more
doaj +1 more source
Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection [PDF]
, 2011 Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Andrew, P W +16 more
core +14 more sources
mSystems, 2021 Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin +10 more
doaj +1 more source
Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]
, 2012 The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant +85 more
core +11 more sources
Burden of malaria infection among individuals of varied blood groups in Kenya
Malaria Journal, 2022 Background The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans.
Redemptah Yeda +17 more
doaj +1 more source
PLoS Medicine, 2017 Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts. Suboptimal responses to drugs and insecticides are both spreading geographically and
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
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eLife, 2020 This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results.
Samuel J Modlin +9 more
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