Results 231 to 240 of about 4,798,630 (303)

Comparative and Subtractive Genomics Analysis of Multidrug-Resistant <i>Klebsiella pneumoniae</i> Strains for Novel Target Identification and Drug Repurposing Strategies. [PDF]

Int J Microbiol
Bora M, Paul P, Rajkhowa S, Sonar H, Gohain BB, Zaki MEA, Prabhu D.   +6 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Innovative approaches to therapeutic target discovery amid the global challenge of antimicrobial resistance. [PDF]

J Comput Aided Mol Des
de Oliveira Teixeira T, da Silva RCC, Alves MCS, de Araujo Silva R, Echeverria JES, Simionatto S.   +5 more
europepmc   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

High prevalence of resistance to first-line drugs and multidrug resistance in patients with tuberculosis and type 2 diabetes mellitus at a referral hospital in Peru. [PDF]

PLoS One
Barboza-Panaifo S, Erazo-Cárdenas I, Chapoñan-Agip NV, Tenorio-Quispe A, Yovera-Aldana M.   +4 more
europepmc   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

The Pharmacology of Bacterial Persistence: From Antibiotic Tolerance to Antimicrobial Resistance. [PDF]

Antibiotics (Basel)
Caroleo MC, Pisano M, Cione E, Scumaci D, Cai T, Gallelli L, Leo A.   +6 more
europepmc   +1 more source

[ON BACTERIAL DRUG RESISTANCE. 1. ON EPIDEMIOLOGICAL STUDIES ON THE APPEARANCE OF DRUG RESISTANCE].

Kita Kanto igaku. Kitakanto medical journal, 1996
openaire   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Heteroresistance in <i>Mycobacterium tuberculosis</i>: from molecular mechanisms and advanced detection to clinical implications. [PDF]

Front Cell Infect Microbiol
Liu S, Chen D, Zhang J, Zhu M.
europepmc   +1 more source