Results 91 to 100 of about 160,880 (298)

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]

PLoS Pathogens, 2010
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen   +7 more
doaj   +1 more source

Compounding Effects of Climate Warming and Antibiotic Resistance. [PDF]

, 2020
Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to ...
Cruz-Loya, Mauricio, Lozano-Huntelman, Natalie, Rodríguez-Verdugo, Alejandra, Savage, Van, Yeh, Pamela   +4 more
core   +1 more source

Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens [PDF]

Scientific Reports, 2016
AbstractFour naphtho-γ-pyrones (fonsecinones A and C and aurasperones A and E) were identified as potential antibacterial agents againstEscherichia coli, extended-spectrumβ-lactamase (ESBL)-producingE. coli, Pseudomonas aeruginosa, Enterococcus faecalis, and methicillin-resistantStaphylococcus aureus(MRSA) in anin vitroantibacterial screen of 218 ...
Yan He, Jun Tian, Xintao Chen, Weiguang Sun, Hucheng Zhu, Qin Li, Liang Lei, Guangmin Yao, Yongbo Xue, Jianping Wang, Hua Li, Yonghui Zhang   +11 more
openaire   +2 more sources

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Candida antifungal drug resistance in sub-Saharan African populations: A systematic review [version 2; referees: 2 approved]

F1000Research, 2017
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa, Pedro Miguel dos Santos Abrantes   +1 more
doaj   +1 more source

Ellagic acid: an alternative for antifungal drugs resistance in HIV/AIDS patients with oropharyngeal candidiasis

HIV & AIDS Review. International Journal of HIV-Related Problems, 2020
Oropharyngeal candidiasis (OPC) is considered the most common fungal infection in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. Antifungal drug, azole group, is the preferred treatment.
Satutya Wicaksono, Fianza Rezkita, Fadhilah N. Wijaya, Alexander P. Nugraha, Saka Winias   +4 more
doaj   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Candida antifungal drug resistance in sub-Saharan African populations: A systematic review [version 1; referees: 2 approved]

F1000Research, 2016
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa, Pedro Miguel dos Santos Abrantes   +1 more
doaj   +1 more source

Macrophage Migration Is Impaired within Candida albicans Biofilms [PDF]

, 2017
Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant ...
Alonso, Maria F., Bain, Judith M., Erwig, Lars P., Gow, Neil A. R.   +3 more
core   +2 more sources

MBX-7591: a promising drug candidate against drug-resistant fungal infections

mBio
ABSTRACT Invasive fungal infections (IFIs) caused by pathogenic fungi pose a significant public health concern, particularly for immunocompromised individuals. Mortality rates for IFIs remain high, and currently available treatment options are limited.
Nivea Pereira de Sa, Maurizio Del Poeta
openaire   +3 more sources