Results 91 to 100 of about 543,044 (334)

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

Journal of Fungi, 2020
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image.
Hans Carolus, Siebe Pierson, K. Lagrou, P. van Dijck   +3 more
semanticscholar   +1 more source

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies

Turkish Journal of Hematology, 2018
Invasive fungal infections caused by drug-resistant organisms are an emerging threat to heavily immunosuppressed patients with hematological malignancies.
Maria N. Gamaletsou, Thomas J. Walsh, Nikolaos V. Sipsas   +2 more
doaj   +1 more source

Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. [PDF]

PLoS Genetics, 2013
The evolution of drug resistance in fungal pathogens compromises the efficacy of the limited number of antifungal drugs. Drug combinations have emerged as a powerful strategy to enhance antifungal efficacy and abrogate drug resistance, but the impact on ...
Jessica A Hill, Ron Ammar, Dax Torti, Corey Nislow, Leah E Cowen   +4 more
doaj   +1 more source

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

Nature Communications, 2022
Fungal infections cause more than 1.5 million deaths annually. With an increase in immune-deficient susceptible populations and the emergence of antifungal drug resistance, there is an urgent need for novel strategies to combat these life-threatening ...
Nicole M. Revie, K. Iyer, Michelle E. Maxson, Jiabao Zhang, S. Yan, C. M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, H. Sanchez, Saif Hossain, Sheena C. Li, Yoko Yashiroda, H. Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, D. Andes, Gerard D. Wright, J. Nodwell, M. Del Poeta, Martin D. Burke, L. Whitesell, Nicole Robbins, L. Cowen   +26 more
semanticscholar   +1 more source

Polyferrocene‐Based Cubosomes: Conversion to Magnetic Mesoporous Microparticles, Supramolecular Modification, and Oxidation Response

Advanced Functional Materials, EarlyView.
Polyferrocene block copolymers are synthesized and assembled into micron‐sized polymer cubosomes with double diamond lattice and pore diameter of ≈30 nm. The ferrocene functionality is retained within the polymer cubosome wall as demonstrated on supramolecular modification, and oxidative disassembly.
Chin Ken Wong, Suna Azhdari, Marvin Foith, Chen Chen, André H. Gröschel   +4 more
wiley   +1 more source

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. [PDF]

PLoS Pathogens, 2010
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening ...
Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen   +7 more
doaj   +1 more source

Fungal infections of the central nervous system: A review of fungal pathogens and treatment [PDF]

, 2007
Multiple factors influence the outcome of fungal infection of the central nervous system (CNS). The host and the pathogen in concert with drug delivery across the blood-brain barrier and drug activity are key factors in outcome.
Dancer, C., Redmond, A., Woods, M. L.
core   +1 more source

Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis [PDF]

, 2020
Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients.
Agrawal, Vaibhav, Brinda, Bryan J., Farag, Sherif S.   +2 more
core   +1 more source

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source