Results 81 to 90 of about 613,359 (339)

Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris

mBio, 2021
Despite the recently growing concern of pan-resistant Candida auris infection, the pathogenicity of this ascomycetous fungal pathogen and the signaling circuitries governing its resistance to antifungal drugs are largely unknown.
Ji-Seok Kim, Kyung-Tae Lee, M. Lee, Eunji Cheong, Yong-Sun Bahn   +4 more
semanticscholar   +1 more source

Drug resistant fungal infections An emerging threat

Journal of Dhaka National Medical College & Hospital, 2018
Drug resistance has become an important problem leading to significant negative social, psychological, and occupational health effects and quality of life. Clinical failure and relapses have been observed in patients treated with antifungal drugs. Now a days, Antifungal drug resistance is becoming an emerging threat in management of fungal infections ...
Wazeda Begum, Md Saiful Kabir, Md Maruf Ur Rahman, Md Mostafizur Rahman   +3 more
openaire   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Flipping and other astonishing transporter dance moves in fungal drug resistance

BioEssays, 2022
AbstractIn all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR) subfamily confer antibiotic resistance and so are of interest as therapeutic targets.
Raschka, Stefanie L, Harris, Andrzej, Luisi, Ben F, Schmitt, Lutz   +3 more
openaire   +2 more sources

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

Cell Reports, 2012
The molecular chaperone Hsp90 is a hub of protein homeostasis and regulatory circuitry. Hsp90 function is regulated by posttranslational modifications including acetylation in mammals; however, whether this regulation is conserved remains unknown.
Nicole Robbins, Michelle D. Leach, Leah E. Cowen   +2 more
doaj   +1 more source

Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source

A reverse chemical ecology approach to explore wood natural durability [PDF]

, 2020
The natural durability of wood species, defined as their inherent resistance to wood‐destroying agents, is a complex phenomenon depending on many biotic and abiotic factors.
Beauchène J., Eric Gelhaye, Guillaume Salzet, Jacques Beauchene, Mélanie Morel‐Rouhier, Nadine Amusant, Philippe Gérardin, Rodnay Sormani, Stéphane Dumarçay, Taylor A.M., Thomas Perrot, XP CEN/TS 15083‐2   +11 more
core   +3 more sources

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

Nature Microbiology
Phylogenetics and convergence-based genome-wide association studies were used to analyse genomic variants across approximately 2,000 isolates from six Candida species to reveal how Candida fungal pathogens adapt to drugs and clinical environments ...
Miquel Àngel Schikora-Tamarit, T. Gabaldón   +1 more
semanticscholar   +1 more source

Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection

Infection & Chemotherapy, 2022
Candida auris is an invasive fungal pathogen that has been recognized globally as a serious health threat due to its extensive innate and acquired resistance to antifungal drugs. A growing number of emerging cases of C.
A. Sanyaolu, C. Okorie, A. Marinkovic, A. Abbasi, S. Prakash, J. Mangat, Zaheeda Hosein, N. Haider, J. Chan   +8 more
semanticscholar   +1 more source