Results 81 to 90 of about 543,044 (334)

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.

Chemical Reviews, 2020
Fungal infections are a major contributor to infectious disease-related deaths across the globe. Candida species are among the most common causes of invasive mycotic disease, with Candida albicans reigning as the leading cause of invasive candidiasis ...
Yunjin Lee, Emily Puumala, Nicole Robbins, L. Cowen   +3 more
semanticscholar   +1 more source

Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]

, 2016
AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke, B Ferwerda, BN Gantner, C Kuei, CA Johnston, CA Munro, CA Rappleye, CJ Barelle, CJ Heilmann, DH Owen, DO Inglis, E Leberer, FN Gravelat, G Bindea, GD Brown, GJ Sosinska, HJ Flint, I Jacobs, ID Iliev, IV Ene, IV Ene, IV Ene, IV Ene, JE Nett, JM Bain, K Lemaire, LE Lewis, LM Graham, M Galán-Díez, M Karababa, M Santos, MG Netea, MG Netea, MJ Marakalala, MM Maidan, MT Kelly, N Vieira, NAR Gow, P Shannon, PR Desai, RA Hall, RT Wheeler, RT Wheeler, RT Wheeler, S Lev, S Shahana, SdJ Carrion, SE Hardison, SM Noble, TR O'Meara, YL Chen   +50 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

Cell Reports, 2012
The molecular chaperone Hsp90 is a hub of protein homeostasis and regulatory circuitry. Hsp90 function is regulated by posttranslational modifications including acetylation in mammals; however, whether this regulation is conserved remains unknown.
Nicole Robbins, Michelle D. Leach, Leah E. Cowen   +2 more
doaj   +1 more source

Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris

mBio, 2021
Despite the recently growing concern of pan-resistant Candida auris infection, the pathogenicity of this ascomycetous fungal pathogen and the signaling circuitries governing its resistance to antifungal drugs are largely unknown.
Ji-Seok Kim, Kyung-Tae Lee, M. Lee, Eunji Cheong, Yong-Sun Bahn   +4 more
semanticscholar   +1 more source

Antimicrobial Activities and Mechanisms of Magnesium Oxide Nanoparticles (nMgO) against Pathogenic Bacteria, Yeasts, and Biofilms. [PDF]

, 2018
Magnesium oxide nanoparticle (nMgO) is a light metal based antimicrobial nanoparticle that can be metabolized and fully resorbed in the body. To take advantage of the antimicrobial properties of nMgO for medical use, it is necessary to determine the ...
Grelling, Nathaniel, Liu, Huinan, Nguyen, Nhu-Y Thi, Rosario, Romeo, Wetteland, Cheyann Lee   +4 more
core   +3 more sources

A reverse chemical ecology approach to explore wood natural durability [PDF]

, 2020
The natural durability of wood species, defined as their inherent resistance to wood‐destroying agents, is a complex phenomenon depending on many biotic and abiotic factors.
Beauchène J., Eric Gelhaye, Guillaume Salzet, Jacques Beauchene, Mélanie Morel‐Rouhier, Nadine Amusant, Philippe Gérardin, Rodnay Sormani, Stéphane Dumarçay, Taylor A.M., Thomas Perrot, XP CEN/TS 15083‐2   +11 more
core   +1 more source

Glutathione and Laccase Dual‐Responsive Lignin Nanocarriers Inspired by Host‐Pathogen Interactions for Fungicide Delivery

Advanced Functional Materials, EarlyView.
Discover bio‐inspired fungicide‐loaded lignin nanocarriers that mimic host‐pathogen interactions, unleashing targeted fungicide release in response to glutathione and laccase. These innovative biobased nanocarriers promise superior crop protection, with increased photostability, enhanced foliar retention, and enabling bidirectional translocation for a ...
Wenlong Liang, Jingli Cheng, Lianmeng Liu, Jinhao Zhao, Frederik R. Wurm   +4 more
wiley   +1 more source

Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence [PDF]

Pest Management Science, 2006
AbstractDrug transporters are membrane proteins that provide protection for organisms against natural toxic products and fungicides. In plant pathogens, drug transporters function in baseline sensitivity to fungicides, multidrug resistance (MDR) and virulence on host plants.
de Waard, M.A., Andrade, A.C., Hayashi, K., Schoonbeek, H., Stergiopoulos, I., Zwiers, L.H.   +5 more
openaire   +4 more sources

Emergence of fluconazole-resistant candida infections in diabetic foot ulcers: Implications for public health

Indian Journal of Community Medicine, 2019
Background: It is well documented in the literature that fungal infections are common in diabetic foot ulcers (DFUs). This has led to an overuse of antifungal agents, namely fluconazole, with a consequent risk of emergence of resistance to this drug ...
Chankramath S Arun, Priyanka Raju, Vivek Lakshmanan, Anil Kumar, Arun Bal, Harish Kumar   +5 more
doaj   +1 more source