Bone Marrow Stroma-induced Transcriptome Signatures of Multiple Myeloma as Modulated by JUNB [PDF]
, 2022 The bone marrow (BM) microenvironment acts as a breeding ground for drug resistance in multiple myeloma (MM). The interaction with bone marrow stromal cells (BMSCs) confer environment-mediated drug resistance (EMDR) to multiple myeloma.
Gandhi, Jasleen Kaur
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Troglitazone reverses the multiple drug resistance phenotype in cancer cells
Drug Design, Development and Therapy, 2009 Gerald F Davies1, Bernhard HJ Juurlink2, Troy AA Harkness11Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada; 2College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi ArabiaAbstract: A ...
Gerald F Davies +2 more
doaj
Understanding and targeting resistance mechanisms in cancer
MedComm, 2023 Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
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Understanding the evolution of multiple drug resistance in structured populations
eLife, 2021 The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood.
David V McLeod, Sylvain Gandon
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Mechanisms of Drug Resistance in Relapse and Refractory Multiple Myeloma
BioMed Research International, 2015 Multiple myeloma (MM) is a hematological malignancy that remains incurable because most patients eventually relapse or become refractory to current treatments.
Wen-Chi Yang, Sheng-fung Lin
semanticscholar +1 more source
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment
Frontiers in Cell and Developmental Biology, 2021 Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug resistance. However, recent evidence showed that tumor microenvironment
Yanghong Ni +6 more
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Evolution of multiple drug resistance in staphylococci [PDF]
Microbiology Australia, 2008 Since the dawn of the era of antibiotic therapy, beginning with the introduction of the first penicillins ( -lactams) in the 1940s, strains of Staphylococcus aureus exhibiting resistance to antibiotics have become more and more prevalent in both clinical and community settings.
Jensen, Slade O. +3 more
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FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Peroxiredoxin III : a candidate for drug resistance to chemotherapy : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]
, 2008 The development of drug resistance to chemotherapeutic drugs is a serious obstacle in the successful treatment of cancer. New cancer drugs are continually being developed with the goal of increasing the effectiveness of chemotherapy.
Aalderink, Miranda
core
Modeling continuous levels of resistance to multidrug therapy in cancer [PDF]
, 2018 Multidrug resistance consists of a series of genetic and epigenetic alternations that involve multifactorial and complex processes, which are a challenge to successful cancer treatments. Accompanied by advances in biotechnology and high-dimensional data analysis techniques that are bringing in new opportunities in modeling biological systems with ...
arxiv +1 more source