Results 101 to 110 of about 2,071,500 (370)

Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?

OncoTarget, 2015
Multiple myeloma (MM) remains a largely incurable, genetically heterogeneous plasma-cell malignancy that contains – just like many other cancers – a small fraction of clonogenic stem cell-like cells that exhibit pronounced self-renewal and ...
Reinaldo Franqui-Machin, Erik B Wendlandt, S. Janz, F. Zhan, G. Tricot   +4 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Multidrug resistance by microorganisms: a review [PDF]

, 2021
Multiple drug resistance (MDR) is the ability of some microorganisms to resist the actions of multiple antimicrobial agents. MDR include those resistant to multiple antibacterial, antifungal, antiviral, and anti-parasitic drugs.
Adeke , M., Baba, J., Butt , A.Q., Musa , B.J., Suleiman , U., Tayaza , F.B., Wartu , J.R.   +6 more
core   +1 more source

Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

Туберкулез и болезни лёгких, 2015
The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV ...
Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova   +2 more
doaj  

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies [PDF]

, 2014
The development of a drug-resistant cell line can take from 3 to 18 months. However, little is published on the methodology of this development process. This article will discuss key decisions to be made prior to starting resistant cell line development;
Breen, Laura, Busschots, Steven, Clynes, Martin, Crown, John, Eustace, Alex J., McDermott, Martina, O'Donovan, Norma, Stordal, Britta K.   +7 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria [PDF]

, 2014
Background: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms ...
Broadbent, Kate M, Clish, Clary B, Deik, Amy A, Desai, Michael M, Herman, Jonathan D, Mazitschek, Ralph, Moss, Eli L, Neafsey, Daniel E, Ribacke, Ulf, Rice, Daniel P, Silterra, Jacob, Wirth, Dyann F   +11 more
core   +1 more source