Results 131 to 140 of about 2,071,500 (370)

NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma

OncoTarget, 2014
We reported previously that increased expression of aldehyde dehydrogenase 1 (ALDH1) in multiple myeloma (MM) is a marker of tumor-initiating cells (TICs) that is further associated with chromosomal instability (CIN).
Ye Yang, Wen Zhou, Jiliang Xia, Zhimin Gu, Erik B Wendlandt, Xin Zhan, S. Janz, G. Tricot, F. Zhan   +8 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Crucial stages of protein folding through a solvable model: predicting target sites for enzyme-inhibiting drugs

, 2002
An exactly solvable model based on the topology of a protein native state is applied to identify bottlenecks and key-sites for the folding of HIV-1 Protease. The predicted sites are found to correlate well with clinical data on resistance to FDA-approved
Ala, Alessandro Flammini, Alm, Amos Maritan, Atilgan, Bahar, Bahar, Baker, Camacho, Camacho, Cecconi, Chan, Chiti, Clementi, Condra, Cristian Micheletti, Debe, Fabio Cecconi, Fersht, Flory, Galzitskaya, Go, Hoang, Jackson, Jacobsen, Kaya, Kaya, Keskin, Kloczkowski, Lazaridis, Maiorov, Maritan, Markowitz, Martinez, Micheletti, Micheletti, Micheletti, Miyazawa, Molla, Patick, Plaxco, Reddy, Riddle, Sali, Seno, Settanni, Sippl, Tisdale, Wolynes   +48 more
core   +2 more sources

Molar ratios of therapeutic water-soluble phenothiazine⋅water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure–activity relationships [PDF]

, 2015
The fact that non-antibiotics can sensitise microorganisms for antibiotic treatment suggests that these molecules have valuable potential to treat multiple drug resistance.
Fey, S. J., Keyzer, Hendrik, Kristiansen, Jette E., Thornton, Barry   +3 more
core   +1 more source

Investigating the development of chemotherapeutic drug resistance in cancer: A multiscale computational study [PDF]

arXiv, 2014
Chemotherapy is one of the most important therapeutic options used to treat human cancers, either alone or in combination with radiation therapy and surgery. Recent studies have indicated that intra-tumoural heterogeneity has a significant role in driving resistance to chemotherapy in many human malignancies.
arxiv  

Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer (Review)

Experimental and Therapeutic Medicine, 2014
In recent years, the cancer stem cell (CSC) theory has provided a new angle in the research of cancer, and has gradually gained significance. According to this theory, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of ...
Chong Di, Yao-dong Zhao
semanticscholar   +1 more source

The evolution of multiple drug resistance in malaria parasites

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1998
Forces determining the rate of spread of drug resistance in malaria were explored using a genetics transmission model which took account of the strong population structure of these parasites. The rate of change of frequency of drug resistant mutants in the parasite population is primarily a function of the proportion of hosts treated with drugs, and ...
Mackinnon, M, Hastings, I
openaire   +4 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy [PDF]

, 2014
Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic level within solid tumors as well as on the macroscopic level across metastases may also contribute
arxiv   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source