Results 1 to 10 of about 504,655 (311)

Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients [PDF]

Retrovirology, 2012
Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to ...
Theys Kristof, Deforche Koen, Vercauteren Jurgen, Libin Pieter, van de Vijver David AMC, Albert Jan, Åsjö Birgitta, Balotta Claudia, Bruckova Marie, Camacho Ricardo J, Clotet Bonaventura, Coughlan Suzie, Grossman Zehava, Hamouda Osamah, Horban Andrzei, Korn Klaus, Kostrikis Leondios G, Kücherer Claudia, Nielsen Claus, Paraskevis Dimitrios, Poljak Mario, Puchhammer-Stockl Elisabeth, Riva Chiara, Ruiz Lidia, Liitsola Kirsi, Schmit Jean-Claude, Schuurman Rob, Sönnerborg Anders, Stanekova Danica, Stanojevic Maja, Struck Daniel, Van Laethem Kristel, Wensing Annemarie MJ, Boucher Charles AB, Vandamme Anne-Mieke   +34 more
doaj   +13 more sources

High viremia and low level of transmitted drug resistance in anti-retroviral therapy-naïve perinatally-infected children and adolescents with HIV-1 subtype C infection [PDF]

BMC Infectious Diseases, 2012
Background High plasma viremia in HIV-1 infection is associated with rapid CD4 cell decline and faster disease progression. Children with HIV infection have high viral loads, particularly in early childhood.
Neogi Ujjwal, Sahoo Pravat Nalini, De Costa Ayesha, Shet Anita   +3 more
doaj   +2 more sources

“I feel drug resistance testing allowed us to make an informed decision”: qualitative insights on the role of HIV drug resistance mutation testing among children and pregnant women living with HIV in western Kenya

BMC Health Services Research, 2023
Background Pregnant women and children living with HIV in Kenya achieve viral suppression (VS) at lower rates than other adults. While many factors contribute to these low rates, the acquisition and development of HIV drug resistance mutations (DRMs) are
Andrea J. Scallon, Shukri A. Hassan, Shirley Rui Qian, Yuandi Gao, Patrick Oyaro, Evelyn Brown, James Wagude, Irene Mukui, Eunice Kinywa, Frederick Oluoch, Francesca Odhiambo, Boaz Oyaro, Leonard Kingwara, Nashon Yongo, Enericah Karauki, Lindah Otieno, Grace C. John-Stewart, Lisa L. Abuogi, Rena C. Patel   +18 more
doaj   +1 more source

A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion [PDF]

, 2013
Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide, are peptides designed to competitively inhibit the viral fusion protein ...
A Adachi, A Cole, A Cole, A Cole, Alan J. Waring, Alexander M. Cole, AM Barrio, AM Cole, Amy L. Cole, C Baldwin, C Baldwin, C Fuhrman, CR Eade, CT Wild, D Chan, D Eggink, E Micewicz, E Poveda, G Melikyan, GB Fields, J Kimpton, J Reeves, K Miyauchi, L Furci, Lisa C. Rohan, LJ Reed, M Caffrey, Matthew P. Wood, N Ray, Patrick M. Tarwater, Phalguni Gupta, Piotr Ruchala, Preston Marx, RP Lamers, S Gallo, S Owen, Shan-Lu Liu, T Chang, VD Trivedi, X Wei, Y He, Z Liu   +41 more
core   +13 more sources

HIV-1 resistance profile in plasma and peripheral blood lymphocytes in a group of naive patients [PDF]

Archives of Biological Sciences, 2012
Transmitted HIV-1 drug resistance (TDR) is a persisting problem, even though the prevalence of primary resistance may remain stable or start to decline.
Šiljić Marina, Salemović Dubravka, Jevtović Đ., Pešić-Pavlović Ivana, Zerjav Sonja, Nikolić Valentina, Stanojević Maja   +6 more
doaj   +1 more source

Uptake of antiretroviral treatment and viral suppression among men who have sex with men and transgender women in sub-Saharan Africa in an observational cohort study: HPTN 075

International Journal of Infectious Diseases, 2021
Objectives: HPTN 075 enrolled men who have sex with men (MSM) and transgender women (TGW) in sub-Saharan Africa. Persons in HIV care or on antiretroviral treatment (ART) were not eligible to enroll.
Philip J. Palumbo, Yinfeng Zhang, William Clarke, Autumn Breaud, Mariya Sivay, Vanessa Cummings, Erica L. Hamilton, Xu Guo, Arthur Ogendo, Noel Kayange, Ravindre Panchia, Karen Dominguez, Ying Q. Chen, Theodorus G.M. Sandfort, Susan H. Eshleman   +14 more
doaj   +1 more source

An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness

Viruses, 2021
Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a model to ...
Erika Trompet, Arturo Temblador, Sarah Gillemot, Dimitrios Topalis, Robert Snoeck, Graciela Andrei   +5 more
doaj   +1 more source

Treatment effect and drug-resistant mutations in Chinese AIDS patients switching to second-line antiretroviral therapy. [PDF]

PLoS ONE, 2014
This study aimed to investigate treatment effect, drug resistance changes, and their influencing factors in Chinese AIDS patients after switching to second-line antiretroviral therapy, and thus provide important information for the scale-up of second ...
Min Zhang, Mingquan Shang, Weiwei Yang, Junli Chen, Zhe Wang, Hong Shang   +5 more
doaj   +1 more source

Potential challenges to sustained viral load suppression in the HIV treatment programme in South Africa: a narrative overview

AIDS Research and Therapy, 2021
Background South Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016.
Pascal O. Bessong, Nontokozo D. Matume, Denis M. Tebit   +2 more
doaj   +1 more source

Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2

Molecules, 2022
Viral resistance is a worldwide problem mitigating the effectiveness of antiviral drugs. Mutations in the drug-targeting proteins are the primary mechanism for the emergence of drug resistance. It is essential to identify the drug resistance mutations to
Dharmeshkumar Patel, Suzane K. Ono, Leda Bassit, Kiran Verma, Franck Amblard, Raymond F. Schinazi   +5 more
doaj   +1 more source