Results 241 to 250 of about 835,419 (313)

A LRELHLNNN-Gal‑3 Modified Adipose Decellularized Scaffold To Construct Colorectal Cancer Model for Anticancer Drug Screening and Immunotherapy. [PDF]

ACS Omega
Liang W, Li H, Ao R, Yang Z, Yang W, Han M, Zheng M, Guo H, Chen L, Lin J, An Y.   +10 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Collagen-Embedded Three-Dimensional Spheroid Model Based on Breast and Cervical Cancer for Drug Screening Application. [PDF]

Cureus
Kulkarni P, Khare S, Bramhachari S, Das S, Kapoor N, Goel SK, Kumar P, Kumar A, Arya N.   +8 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Evolution of Preclinical Models for Glioblastoma Modelling and Drug Screening. [PDF]

Curr Oncol Rep
Thomas G, Rahman R.
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Cell Viability, Drug Screening, and Mechanism Study Under Mild Phototherapy Integrated Chemotherapy (PIC). [PDF]

Adv Sci (Weinh)
Li T, Wang S, Ling Q, Sun J, Yang N, Fu Z, Zhang Z, Chen S, Wang Y, Yu N, Wang Y, Ding Z, Liu H, Jia Y, Wang Y, Zhang X.   +15 more
europepmc   +1 more source

3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis. [PDF]

Biochem Biophys Rep
Han HJ, Kim H.
europepmc   +1 more source

A feasibility of computational drug screening for Fuchs endothelial corneal dystrophy. [PDF]

Sci Rep
Oka I, Toyokawa Y, Imai K, Nakagawa T, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N, Okumura N.   +8 more
europepmc   +1 more source

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening. [PDF]

Biomaterials
Nasiri R, Madadelahi M, Nikmaneshi MR, Gokce B, Bijarchi MA, Shah S, Tirpáková Z, Van Gastel D, Taebnia N, de Barros NR, Zhu Y, Morcimen ZG, Gulicli B, Habibey R, Sendemir A, Jain S, Enrico A, Lauschke VM, Dokmeci MR, Pratx G, Khademhosseini A, Herland A.   +21 more
europepmc   +1 more source