Results 31 to 40 of about 1,604,042 (306)

Effect of the Uniform Accident and Sickness Policy Provision Law on Alcohol Screening and Intervention in Trauma Centers [PDF]

open access: yes, 2006
Outlines how a law allowing insurers to deny payment for injury claims if alcohol or drug use was involved prevents alcohol screening and interventions to reduce alcohol use, repeat injuries, and healthcare costs.
Deanna Lewis
core   +1 more source

Urine Screening for Opiod and Illicit Drugs in the Total Joint Arthroplasty Population [PDF]

open access: yes, 2020
Introduction. Recent studies have shown an increase in post-operative orthopaedic complications associated with pre-operative opioid use. It is, therefore, important to know if patients use opioids before scheduled surgery.
Bhargava, Tarun   +6 more
core   +2 more sources

In-silico Predictive Mutagenicity Model Generation Using Supervised Learning Approaches [PDF]

open access: yes, 2011
With the advent of High Throughput Screening techniques, it is feasible to filter possible leads from a mammoth chemical space that can act against a particular target and inhibit its action.
Abhik Seal   +4 more
core   +2 more sources

Pharmacogenomic testing and its future in community pharmacy [PDF]

open access: yes, 2020
Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core   +1 more source

Insoluble Fiber in Barley Leaf Attenuates Hyperuricemic Nephropathy by Modulating Gut Microbiota and Short-Chain Fatty Acids

open access: yesFoods, 2022
Hyperuricemia (HUA), characterized by abnormal serum uric acid (UA) levels, is recognized as an important risk factor for hyperuricemic nephropathy (HN), which is strongly linked to gut microbiota.
Yongmei Li   +8 more
doaj   +1 more source

Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo

open access: yesMolecules, 2015
Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate.
Yu-Rong Wang   +6 more
doaj   +1 more source

Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

open access: yesNature Communications, 2021
Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post ...
Boning Niu   +9 more
doaj   +1 more source

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z [PDF]

open access: yes, 2019
The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals.
Andrew S. Chu (6256490)   +12 more
core   +3 more sources

Effects of sulfometuron-methyl on zebrafish at early developmental stages

open access: yesEcotoxicology and Environmental Safety, 2021
Sulfometuron methyl (SM) is a widely used herbicide and thus leading to accumulation in the environment. The toxicity assessments of SM in model organisms are currently rare.
Wei Yuan   +18 more
doaj   +1 more source

One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening [PDF]

open access: yes, 2019
Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and ...
Bae, Hyung Jong   +10 more
core   +1 more source

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