Results 51 to 60 of about 1,604,042 (306)

Comparison of a checklist for clinical signs of impairment and detection of drugs in saliva [PDF]

, 2010
Objectives: In Belgium and some other countries, the police performs on-site drug screening when a driver is suspected of being drug impaired, since the test procedure is time consuming and the screening devices are relatively expensive. The objective of
Goessaert, An-Sofie, Legrand, Sara-Ann, Veramme, Jolien, Verstraete, Alain   +3 more
core  

Expression proteomics reveals protein targets and highlights mechanisms of action of small molecule drugs

, 2014
Phenomenological screening of small molecule libraries for anticancer activity yields potentially interesting candidate molecules, with a bottleneck in the determination of drug targets and the mechanism of anticancer action.
Chernobrovkin, Alexey, Vicente, Consuelo Marin, Visa, Neus, Zubarev, Roman A.   +3 more
core   +1 more source

Quantifying biogenic bias in screening libraries. [PDF]

, 2009
In lead discovery, libraries of 10(6) molecules are screened for biological activity. Given the over 10(60) drug-like molecules thought possible, such screens might never succeed.
Hert, Jérôme, Irwin, John J, Keiser, Michael J, Laggner, Christian, Shoichet, Brian K   +4 more
core   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

Criterion‐Related Validity of the Neuropsychological Quick Assessment for Screening Cognitive, Motor, and Behavioral Impairments in Patients With Pediatric Brain Tumors: An Observational Pilot Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neuropsychological complications may impair the qualitative prognosis of patients with pediatric brain tumors. However, multifaceted evaluations cannot be conducted in all patients because they are time consuming and burdensome for patients.
Ami Tabata, Keita Ueda, Tsukasa Ueno, Katsutsugu Umeda, Kentaro Ueno, Kanade Tanaka, Noyuri Nishida, Rie Yamawaki, Megumi Nukui, Yoshiki Arakawa   +9 more
wiley   +1 more source

PPARα regulates YAP protein levels and activity by affecting its ubiquitination modification

BMC Biology
Background Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in liver physiological and pathological processes. Yes-associated protein (YAP) is a key effector in regulating cell growth and organ size.
Wenhong Zhou, Shuaishuai Zhang, Yao Chen, Ziqi Chen, Guofang Bi, Manlan Guo, Xiaowen Jiang, Xiao Yang, Jianhong Fang, Linhu Ye, Shicheng Fan, Huichang Bi   +11 more
doaj   +1 more source

A novel method for screening antihyperuricemic drugs by combining aptamer sensor array, exonuclease III-DNA walker and linear discriminant analysis

Journal of Pharmaceutical Analysis
The lack of a cell-based screening method limits urate-lowering drug development. A novel method combining aptamer sensor array (ASA), exonuclease III (Exo III)- powered 3D DNA walker (DW), and linear discriminant analysis (LDA) was developed for ...
Shiquan Zheng, Jiale Ke, Hanren Chen, Huaze Shao, Fengxin Zheng, Runhui Zhang, Zean Zhao, Jianxin Pang, Lihong Liu   +8 more
doaj   +1 more source

Apoptosis chip for drug screening [PDF]

, 2007
This thesis described the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell ...
Wolbers, Floor
core   +2 more sources

The efficiency of multi-target drugs: the network approach might help drug design

, 2005
Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increase appreciably during the past decade.
Agoston, Vilmos, Csermely, Peter, Pongor, Sandor   +2 more
core   +1 more source