Predicting Synergism of Cancer Drug Combinations Using NCI-ALMANAC Data [PDF]
Frontiers in Chemistry, 2019 Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs. In silico modeling methods can substantially widen this search by
Pavel Sidorov +5 more
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Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro [PDF]
Frontiers in Oncology, 2021 The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni +9 more
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Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2008 Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South
R. P. Mantovani +4 more
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Quantitative Methods for Assessing Drug Synergism [PDF]
Genes & Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Ronald J. Tallarida
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SynAI: an AI-driven cancer drugs synergism prediction platform [PDF]
Bioinformatics Advances, 2023 Abstract Summary The SynAI solution is a flexible AI-driven drug synergism prediction solution aiming to discover potential therapeutic value of compounds in early stage. Rather than providing a finite choice of drug combination or cell lines, SynAI is capable of predicting potential drug synergism ...
Kuan Yan, Runjun Jia, Sheng Guo
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An R Package for Assessing Drug Synergism/Antagonism [PDF]
Journal of Statistical Software, 2010 Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
John C. Boik, Balasubramanian Narasimhan
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Synergistic anti-cancer effects of silibinin-etoposide combination against human breast carcinoma MCF-7 and MDA-MB-231 cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Recently, there is a significant focus on combination chemotherapy for cancer using a cytotoxic drug and a phytochemical compound. We investigated the effect of silibinin on etoposide-induced apoptosis in MCF-7 and MDA-MB-231 breast ...
Mahdie Koushki +4 more
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In vitro and in vivo antimicrobial activity of an active plant-based quadrocomplex for skin hygiene [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: The current epidemiological situation causes a new surge of interest to perspective antimicrobial formulations for proper skin hygiene. Aims: To evaluate in vitro and in vivo the antimicrobial activity of a novel active quadrocomplex (QC) for
Viktor A. Filatov +2 more
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Gels, 2022 Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on
Naved Azum +4 more
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