Results 1 to 10 of about 48,743 (203)
Quantitative methods for assessing drug synergism. [PDF]
Genes Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Tallarida RJ.
europepmc +7 more sources
Drug Synergism as the Basis of Rational Neuroprotection. [PDF]
Neurosci Behav Physiol, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina MV, Teplova NV.
europepmc +3 more sources
Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling [PDF]
Cancers 2023, 15(17), 4210, 2022 Synergistic drug combinations provide huge potentials to enhance therapeutic efficacy and to reduce adverse reactions. However, effective and synergistic drug combination prediction remains an open question because of the unknown causal disease signaling pathways. Though various deep learning (AI) models have been proposed to quantitatively predict the
Zehao Dong +4 more
arxiv +3 more sources
Modeling synergism in early phase cancer trials with drug combination with continuous dose levels: is there an added value? [PDF]
arXiv, 2022 In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there is no added value in including an interaction term to model synergism between the two drugs.
Mourad Tighiouart +3 more
arxiv +3 more sources
Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs [PDF]
Memórias do Instituto Oswaldo Cruz, 2005 Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E ...
Ary Fernandes Júnior +5 more
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Predicting synergism of cancer drug combinations using NCI-ALMANAC data [PDF]
Frontiers in Chemistry, 2018 AbstractBackgroundDrug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs.In silicomodeling methods can substantially widen this search by providing tools able to predict which of all possible combinations in a large ...
Pavel Sidorov +4 more
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Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
Keijiro Takagi, Issei Takayanagi
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Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures [PDF]
PharmaceuticalsBackground: Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due to Carboplatin and Paclitaxel resistance.
Mariana Nunes, Sara Ricardo
doaj +2 more sources
Types of Drug Synergism Classified by the Concentration-Action Curve
Japanese Journal of Pharmacology, 1958 Abstract In the previous experiments of the authors (1), in which it was intended to study the effect of the changes in the temperature, pH or the content in inorganic ions of the bathing fluid upon the shape of the concentration-action (C-A) curves of drugs contracting the excised rabbit intestine, an apparently curious shift of the C-A curve was ...
Hiroshi Matsumoto, Mutsuo Chihara
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