Quantitative methods for assessing drug synergism. [PDF]
Genes Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Tallarida RJ.
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Drug Synergism as the Basis of Rational Neuroprotection. [PDF]
Neurosci Behav Physiol, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina MV, Teplova NV.
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An R Package for Assessing Drug Synergism/Antagonism [PDF]
Journal of Statistical Software, 2010 Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
John C. Boik, Balasubramanian Narasimhan
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New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells [PDF]
Biomolecules, 2020 Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy ...
Diana Duarte, Nuno Vale
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Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
Keijiro Takagi, Issei Takayanagi
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The Acquired Vulnerability Caused by CDK4/6 Inhibition Promotes Drug Synergism Between Oxaliplatin and Palbociclib in Cholangiocarcinoma. [PDF]
Front Oncol, 2022 Suppramote O +12 more
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CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts. [PDF]
Sci Rep, 2022 Huang L +5 more
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Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense. [PDF]
ACS Med Chem Lett, 2020 Ettari R +6 more
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Predicting Synergism of Cancer Drug Combinations Using NCI-ALMANAC Data [PDF]
Frontiers in Chemistry, 2019 Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs. In silico modeling methods can substantially widen this search by
Pavel Sidorov +5 more
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Revisiting the isobole and related quantitative methods for assessing drug synergism. [PDF]
J Pharmacol Exp Ther, 2012 Tallarida RJ.
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