Results 1 to 10 of about 3,800,890 (227)
Revisiting the Isobole and Related Quantitative Methods for Assessing Drug Synergism [PDF]
J Pharmacol Exp Ther, 2012 R. Tallarida
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Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling [PDF]
Cancers, 2022 Simple Summary This paper introduces a novel graph neural network (a hierarchical graph pooling model), SANEpool, to effectively detect core sub-networks of significant genes for predicting the synergy score of drug/drug combinations in cancer.
Zehao Dong +3 more
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Synergistic anti-cancer effects of silibinin-etoposide combination against human breast carcinoma MCF-7 and MDA-MB-231 cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Recently, there is a significant focus on combination chemotherapy for cancer using a cytotoxic drug and a phytochemical compound. We investigated the effect of silibinin on etoposide-induced apoptosis in MCF-7 and MDA-MB-231 breast ...
Mahdie Koushki +4 more
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Gels, 2022 Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on
Naved Azum +4 more
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In vitro and in vivo antimicrobial activity of an active plant-based quadrocomplex for skin hygiene [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: The current epidemiological situation causes a new surge of interest to perspective antimicrobial formulations for proper skin hygiene. Aims: To evaluate in vitro and in vivo the antimicrobial activity of a novel active quadrocomplex (QC) for
Viktor A. Filatov +2 more
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Evaluation the combination of chlorpheniramine and tramadol at a level of thermal and visceral antinociceptive in a mouse acute pain model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 The possible benefits of employing combination treatment include the ability to increase antinociceptive effects while minimizing the occurrence of unfavorable side effects.
Ali I. Thannon, Gada A. Faris
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BMC Cancer, 2021 Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of drug resistance is reduced.
Jonas Parczyk +9 more
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Неврология, нейропсихиатрия, психосоматика, 2021 Objective: to establish the molecular mechanisms of interaction of cytidine-diphosphocholine choline (CDP-choline) with other agents used to treat chronic cerebral ischemia (CCI) to increase the effectiveness of the therapy..Material and methods.
I. Yu. Torshin +6 more
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Frontiers in Oncology, 2021 The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni +9 more
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Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease
Brain Sciences, 2021 Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool +3 more
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