Results 1 to 10 of about 43,453 (280)
Quantitative methods for assessing drug synergism. [PDF]
Genes Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
Tallarida RJ.
europepmc +7 more sources
Drug Synergism as the Basis of Rational Neuroprotection. [PDF]
Neurosci Behav Physiol, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina MV, Teplova NV.
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Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs [PDF]
Memórias do Instituto Oswaldo Cruz, 2005 Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E ...
Ary Fernandes Júnior +5 more
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Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
Keijiro Takagi, Issei Takayanagi
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Predicting synergism of cancer drug combinations using NCI-ALMANAC data [PDF]
Frontiers in Chemistry, 2018 AbstractBackgroundDrug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs.In silicomodeling methods can substantially widen this search by providing tools able to predict which of all possible combinations in a large ...
Pavel Sidorov +4 more
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Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism. [PDF]
Mater Today BioLi M +7 more
europepmc +2 more sources
Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia. [PDF]
PLoS One, 2014 Wan X, Meng J, Dai Y, Zhang Y, Yan S.
europepmc +3 more sources
Predicting synergism of anti-HIV drug pair combinations [PDF]
, 2020 Alexey A. Lagunin +8 more
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Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures [PDF]
PharmaceuticalsBackground: Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due to Carboplatin and Paclitaxel resistance.
Mariana Nunes, Sara Ricardo
doaj +2 more sources