Predicting synergism of cancer drug combinations using NCI-ALMANAC data [PDF]
Frontiers in Chemistry, 2018 AbstractBackgroundDrug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs.In silicomodeling methods can substantially widen this search by providing tools able to predict which of all possible combinations in a large ...
Pavel Sidorov +5 more
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Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling [PDF]
Cancers 2023, 15(17), 4210, 2022 Synergistic drug combinations provide huge potentials to enhance therapeutic efficacy and to reduce adverse reactions. However, effective and synergistic drug combination prediction remains an open question because of the unknown causal disease signaling pathways. Though various deep learning (AI) models have been proposed to quantitatively predict the
Zehao Dong +4 more
arxiv +5 more sources
Mycobacterium Time-Series Genome Analysis Identifies AAC2' as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism. [PDF]
Molecules, 2022 The World Health Organization has put drug resistance in tuberculosis on its list of significant threats, with a critical emphasis on resolving the genetic differences in Mycobacterium tuberculosis. This provides an opportunity for a better understanding
Niranjan V +5 more
europepmc +4 more sources
Visualization of network target crosstalk optimizes drug synergism in myocardial ischemia. [PDF]
PLoS One, 2014 Numerous drugs and compounds have been validated as protecting against myocardial ischemia (MI), a leading cause of heart failure; however, synergistic possibilities among them have not been systematically explored.
Wan X, Meng J, Dai Y, Zhang Y, Yan S.
europepmc +4 more sources
Current Research in Pharmacology and Drug Discovery, 2022 Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undesired side ...
Diana Duarte, Nuno Vale
doaj +2 more sources
Revisiting the isobole and related quantitative methods for assessing drug synergism. [PDF]
J Pharmacol Exp Ther, 2012 Tallarida RJ.
europepmc +4 more sources
Modeling synergism in early phase cancer trials with drug combination with continuous dose levels: is there an added value? [PDF]
arXiv, 2022 In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there is no added value in including an interaction term to model synergism between the two drugs.
Mourad Tighiouart +3 more
arxiv +3 more sources
Infection and Drug Resistance, 2021 Background Retreatment tuberculosis (TB) has become a major source of drug-resistant TB. In contrast to the combination of isoniazid (INH) and rifampicin (RIF), that of pasiniazid (Pa) and rifabutin (RFB) or rifapentine (RFP) appears to have better ...
Ruoyan Ying +6 more
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Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans [PDF]
Frontiers in Nanotechnology, 2021 Candidiasis caused by Candida albicans is one of the most common microbial infections. Azoles, polyenes, allylamines, and echinocandins are classes of antifungals used for treating Candida infections.
Preeti Chand +4 more
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Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs [PDF]
Memórias do Instituto Oswaldo Cruz, 2005 Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E ...
Fernandes Jr., Ary +5 more
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