Results 11 to 20 of about 3,800,890 (227)
Quantitative Methods for Assessing Drug Synergism [PDF]
Genes & Cancer, 2011 Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the combined effect is greater than that predicted by their individual potencies, the combination is said to be synergistic.
R. Tallarida
semanticscholar +7 more sources
Predicting Synergism of Cancer Drug Combinations Using NCI-ALMANAC Data [PDF]
Frontiers in Chemistry, 2019 Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of synergistic combinations by purely experimental means is only feasible on small sets of drugs. In silico modeling methods can substantially widen this search by
Pavel Sidorov +5 more
doaj +10 more sources
Visualization of Network Target Crosstalk Optimizes Drug Synergism in Myocardial Ischemia [PDF]
PLoS One, 2014 Numerous drugs and compounds have been validated as protecting against myocardial ischemia (MI), a leading cause of heart failure; however, synergistic possibilities among them have not been systematically explored.
Xiaojing Wan +4 more
semanticscholar +4 more sources
Mycobacterium Time-Series Genome Analysis Identifies AAC2′ as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism [PDF]
Molecules, 2022 The World Health Organization has put drug resistance in tuberculosis on its list of significant threats, with a critical emphasis on resolving the genetic differences in Mycobacterium tuberculosis. This provides an opportunity for a better understanding
V. Niranjan +5 more
semanticscholar +2 more sources
CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts [PDF]
Sci Rep, 2021 Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, most PDX
Licai Huang +5 more
semanticscholar +2 more sources
Drug Synergism as the Basis of Rational Neuroprotection [PDF]
Neuroscience and Behavioral Physiology, 2022 Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of drug interactions, is a basic approach in clinical practice. Unfortunately, modern pharmacology has no unified way of establishing synergistic spectra of drug actions, which would allow systematic ...
Putilina, M. V., Teplova, N. V.
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Current Research in Pharmacology and Drug Discovery, 2022 Current cancer therapy includes a variety of strategies that can comprise only one type of treatment or a combination of multiple treatments. Chemotherapy is still the gold standard for cancer therapy, though sometimes associated with undesired side ...
Diana Duarte, Nuno Vale
doaj +2 more sources
Infection and Drug Resistance, 2021 Background Retreatment tuberculosis (TB) has become a major source of drug-resistant TB. In contrast to the combination of isoniazid (INH) and rifampicin (RIF), that of pasiniazid (Pa) and rifabutin (RFB) or rifapentine (RFP) appears to have better ...
Ruoyan Ying +6 more
semanticscholar +3 more sources
Propolis: anti-Staphylococcus aureus activity and synergism with antimicrobial drugs [PDF]
Memórias do Instituto Oswaldo Cruz, 2005 Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E ...
Fernandes Jr., Ary +5 more
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Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
Issei Takayanagi, Keijiro Takagi
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