Results 21 to 30 of about 43,453 (280)

Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat

open access: yesPharmaceuticals, 2022
Pharmacological synergism is a current strategy for the treatment of pain. However, few studies have been explored to provide evidence of the possible synergism between a non-steroidal anti-inflammatory drug (NSAID) and a cannabinoid agonist, in order to
M. Irene Díaz-Reval   +7 more
doaj   +1 more source

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

open access: yesFrontiers in Oncology, 2021
The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni   +9 more
doaj   +1 more source

Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease

open access: yesBrain Sciences, 2021
Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool   +3 more
doaj   +1 more source

Chemoreactom analysis of cytidyldiphosphocholine indicates synergistic combinations of neuroprotective agents

open access: yesНеврология, нейропсихиатрия, психосоматика, 2021
Objective: to establish the molecular mechanisms of interaction of cytidine-diphosphocholine choline (CDP-choline) with other agents used to treat chronic cerebral ischemia (CCI) to increase the effectiveness of the therapy..Material and methods.
I. Yu. Torshin   +6 more
doaj   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

open access: yesCase Reports in Dermatology, 2020
Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection).
Guy Shalom, Raed Khoury, Amir Horev
doaj   +1 more source

Toxic Reactions Due to Drug Synergism and Antagonism

open access: bronzeAnesthesia & Analgesia, 1968
S Grosshandler   +2 more
openalex   +4 more sources

In vitro anti-proliferative effect of capecitabine (Xeloda) combined with mocetinostat (MGCD0103) in 4T1 breast cancer cell line by immunoblotting [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2021
Objective(s): Mouse breast cancer cell line 4T1 can accurately mimic the response to immune receptors and targeting therapeutic agents. Combined therapy has emerged as an important strategy with reduced side effects and maximum therapeutic effect ...
Hacer Kaya Cakır, Onur Eroglu
doaj   +1 more source

Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2021
Objective(s): Combination chemotherapy is a beneficial intervention for breast cancer, versus single therapy. We investigated the effect of Metformin (Met) on Lapatinib (Lap)-induced apoptosis in SK-BR3 cells.
Davood Neamati   +6 more
doaj   +1 more source

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

open access: yesCanadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

open access: yesJournal of Venomous Animals and Toxins including Tropical Diseases, 2008
Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South
R. P. Mantovani   +4 more
doaj   +1 more source

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