Results 21 to 30 of about 3,800,890 (227)

An R Package for Assessing Drug Synergism/Antagonism

Journal of Statistical Software, 2010
Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
John C. Boik, Balasubramanian Narasimhan
doaj   +2 more sources

Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins [PDF]

Frontiers in Pharmacology
BackgroundGlioblastoma (GB, grade-IV astrocytoma) is a highly aggressive brain tumor often resistant to treatment with temozolomide (TMZ) due to multidrug resistance (MDR). Researchers are investigating natural compounds, such as chrysin (CHR), with anti-
Yunus Aksüt, Yunus Aksüt, Aslıhan Şengelen, Aslıhan Şengelen, Dudu Melek Gürsoy, İrem Öğütcü, İrem Öğütcü, Özge Kuvet, Murat Pekmez   +8 more
doaj   +2 more sources

Antimalarial drug synergism and antagonism: Mechanistic and clinical significance [PDF]

FEMS Microbiology Letters, 2005
Interactions between antimicrobial agents provide clues as to their mechanisms of action and influence the combinations chosen for therapy of infectious diseases. In the treatment of malaria, combinations of drugs, in many cases acting synergistically, are increasingly important in view of the frequency of resistance to single agents.
A. Bell
openaire   +4 more sources

Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism. [PDF]

Mater Today Bio
Li M, Cheng D, Wang Y, Xuan C, Abashkin V, Xia J, Ding L, Li J.   +7 more
europepmc   +2 more sources

Predicting synergism of anti-HIV drug pair combinations [PDF]

, 2020
Vladimir Poroikov, Olga Tarasova, Dmitry Filimonov, Nadezhda Yu Bizyukova, Anton Smirnov, Alexandra Khromova, Roman Shobik, Sergey Ivanov, Alexey A Lagunin   +8 more
  +4 more sources

Drug Synergism of Proteasome Inhibitors and Mitotane by Complementary Activation of ER Stress in Adrenocortical Carcinoma Cells

Hormones & cancer, 2016
M. Kroiss, S. Sbiera, Sabine Kendl, Max Kurlbaum, M. Fassnacht   +4 more
semanticscholar   +3 more sources

Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells

Biomolecules, 2022
Despite the progressive research and recent advances in drug therapy to treat solid tumours, the number of cases and deaths in patients with cancer is still a major health problem.
Diana Duarte, Alexandra Rêma, Irina Amorim, Nuno Vale   +3 more
doaj   +1 more source

Synergism of Zinc Oxide Quantum Dots with Antifungal Drugs: Potential Approach for Combination Therapy against Drug Resistant Candida albicans

Frontiers in Nanotechnology, 2021
Candidiasis caused by Candida albicans is one of the most common microbial infections. Azoles, polyenes, allylamines, and echinocandins are classes of antifungals used for treating Candida infections.
Preeti Chand, S. Kumari, N. Mondal, Surinder P. Singh, T. Prasad   +4 more
semanticscholar   +1 more source

Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy

Biomedicines, 2023
Despite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate.
Lyvia Eloiza de Freitas Meirelles, Maria Vitória Felipe de Souza, Lucimara Rodrigues Carobeli, Fabrício Morelli, Natália Lourenço Mari, Edilson Damke, Cristiane Suemi Shinobu Mesquita, Jorge Juarez Vieira Teixeira, Marcia Edilaine Lopes Consolaro, Vânia Ramos Sela da Silva   +9 more
doaj   +1 more source

The synergism between alcohols and other drugs

The Journal of Physiology, 1927
L. M. Pickford
openaire   +5 more sources