Results 21 to 30 of about 48,842 (302)

Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines

BMC Cancer, 2021
Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of drug resistance is reduced.
Jonas Parczyk, Jérôme Ruhnau, Carsten Pelz, Max Schilling, Hao Wu, Nicole Nadine Piaskowski, Britta Eickholt, Hartmut Kühn, Kerstin Danker, Andreas Klein   +9 more
doaj   +1 more source

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

Frontiers in Oncology, 2021
The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring ...
Silvia Matteoni, Paola Matarrese, Barbara Ascione, Mariachiara Buccarelli, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi, Claudia Abbruzzese   +9 more
doaj   +1 more source

Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease

Brain Sciences, 2021
Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs).
Hafsa Amat-ur-Rasool, Mehboob Ahmed, Shahida Hasnain, Wayne G. Carter   +3 more
doaj   +1 more source

Toxic Reactions Due to Drug Synergism and Antagonism

Anesthesia & Analgesia, 1968
S Grosshandler, Ernest O. Henschel, John P. Kampine   +2 more
openalex   +4 more sources

Chemoreactom analysis of cytidyldiphosphocholine indicates synergistic combinations of neuroprotective agents

Неврология, нейропсихиатрия, психосоматика, 2021
Objective: to establish the molecular mechanisms of interaction of cytidine-diphosphocholine choline (CDP-choline) with other agents used to treat chronic cerebral ischemia (CCI) to increase the effectiveness of the therapy..Material and methods.
I. Yu. Torshin, O. A. Gromova, L. A. Mayorova, T. R. Grishina, L. E. Fedotova, A. N. Gromov, I. S. Sardaryan   +6 more
doaj   +1 more source

Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat

Pharmaceuticals, 2022
Pharmacological synergism is a current strategy for the treatment of pain. However, few studies have been explored to provide evidence of the possible synergism between a non-steroidal anti-inflammatory drug (NSAID) and a cannabinoid agonist, in order to
M. Irene Díaz-Reval, Yolitzy Cárdenas, Miguel Huerta, Xóchitl Trujillo, Enrique Alejandro Sánchez-Pastor, María Eva González-Trujano, Adolfo Virgen-Ortíz, M. Gicela Pérez-Hernández   +7 more
doaj   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Mycoplasma pneumoniae Infection

Case Reports in Dermatology, 2020
Mycoplasma infection may lower the threshold for drug allergy in particular patients. We present a case of drug reaction with eosinophilia and systemic symptoms (DRESS), with drug etiology and non-drug etiology (Mycoplasma infection).
Guy Shalom, Raed Khoury, Amir Horev
doaj   +1 more source

Combination of Conventional Drugs with Biocompounds Derived from Cinnamic Acid: A Promising Option for Breast Cancer Therapy

Biomedicines, 2023
Despite the options available for breast cancer (BC) therapy, several adverse effects and resistance limit the success of the treatment. Furthermore, the use of a single drug is associated with a high failure rate.
Lyvia Eloiza de Freitas Meirelles, Maria Vitória Felipe de Souza, Lucimara Rodrigues Carobeli, Fabrício Morelli, Natália Lourenço Mari, Edilson Damke, Cristiane Suemi Shinobu Mesquita, Jorge Juarez Vieira Teixeira, Marcia Edilaine Lopes Consolaro, Vânia Ramos Sela da Silva   +9 more
doaj   +1 more source

Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells

Biomolecules, 2022
Despite the progressive research and recent advances in drug therapy to treat solid tumours, the number of cases and deaths in patients with cancer is still a major health problem.
Diana Duarte, Alexandra Rêma, Irina Amorim, Nuno Vale   +3 more
doaj   +1 more source

Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)

Plants, 2021
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden.
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala   +14 more
doaj   +1 more source