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AnRPackage for Assessing Drug Synergism/Antagonism [PDF]
Journal of Statistical Software, 2010 Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and Talalay (1984) for estimating drug interaction indices. One advantage of the MixLow method is that the
Balasubramanian Narasimhan, John C. Boik
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CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts. [PDF]
Sci Rep, 2022 Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, most PDX
Huang L +5 more
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An R Package for Assessing Drug Synergism/Antagonism [PDF]
Journal of Statistical Software, 2010 Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs. Boik, Newman, and Boik (2008) proposed the MixLow method as an alternative to the Median-Effect method of Chou and ...
Balasubramanian Narasimhan, John C. Boik
core +2 more sources
Types of Drug Synergism Classified by the Concentration-Action Curve
Japanese Journal of Pharmacology, 1958 Abstract In the previous experiments of the authors (1), in which it was intended to study the effect of the changes in the temperature, pH or the content in inorganic ions of the bathing fluid upon the shape of the concentration-action (C-A) curves of drugs contracting the excised rabbit intestine, an apparently curious shift of the C-A curve was ...
Mutsuo Chihara, Hiroshi Matsumoto
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Antimalarial drug synergism and antagonism: Mechanistic and clinical significance [PDF]
FEMS Microbiology Letters, 2005 Interactions between antimicrobial agents provide clues as to their mechanisms of action and influence the combinations chosen for therapy of infectious diseases. In the treatment of malaria, combinations of drugs, in many cases acting synergistically, are increasingly important in view of the frequency of resistance to single agents.
A. Bell
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Predicting synergism of anti-HIV drug pair combinations [PDF]
, 2020 Vladimir Poroikov +8 more
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Evaluation the combination of chlorpheniramine and tramadol at a level of thermal and visceral antinociceptive in a mouse acute pain model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 The possible benefits of employing combination treatment include the ability to increase antinociceptive effects while minimizing the occurrence of unfavorable side effects.
Ali I. Thannon, Gada A. Faris
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In vitro and in vivo antimicrobial activity of an active plant-based quadrocomplex for skin hygiene [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: The current epidemiological situation causes a new surge of interest to perspective antimicrobial formulations for proper skin hygiene. Aims: To evaluate in vitro and in vivo the antimicrobial activity of a novel active quadrocomplex (QC) for
Viktor A. Filatov +2 more
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Gels, 2022 Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on
Naved Azum +4 more
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