Results 31 to 40 of about 48,842 (302)

In vitro anti-proliferative effect of capecitabine (Xeloda) combined with mocetinostat (MGCD0103) in 4T1 breast cancer cell line by immunoblotting [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Mouse breast cancer cell line 4T1 can accurately mimic the response to immune receptors and targeting therapeutic agents. Combined therapy has emerged as an important strategy with reduced side effects and maximum therapeutic effect ...
Hacer Kaya Cakır, Onur Eroglu
doaj   +1 more source

A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose Patients with body weights close to or above 400 lbs present unique challenges in radiation therapy since the weight limit of most treatment couches decreases as the couch‐top extends toward the treatment gantry. The purpose of this work was to develop a small footprint couch‐top support platform to safely perform image‐guided ...
Huixiao Chen, Kevin Morley, Ronnie Rodriguez, Emily Draeger, Muhammad Shafiq ul Hassan, Zhe (Jay) Chen   +5 more
wiley   +1 more source

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

Canadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South
R. P. Mantovani, V. L. M. Rall, J. E. N. Batalha, A. A. H. Fernandes, A. Fernandes Junior   +4 more
doaj   +1 more source

Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Combination chemotherapy is a beneficial intervention for breast cancer, versus single therapy. We investigated the effect of Metformin (Met) on Lapatinib (Lap)-induced apoptosis in SK-BR3 cells.
Davood Neamati, Azam Khedri, Mohammad Aberomand, Ali-Asghar Hemati, Maryam Mohammadzadeh, Kourosh Akbari Baghbani, Ghorban Mohammadzadeh   +6 more
doaj   +1 more source

Accuracy of patient dose estimation in cone beam computed tomography in breast irradiation by size‐specific dose estimates with position correction

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract This study aims to investigate the effects of the position correction of size‐specific dose estimates (SSDE) on patient dose estimation in cone beam computed tomography (CBCT). The relationship between the phantom position and absorbed dose in the right breast was studied using optically stimulated luminescence dosimeters and a simulated human
Hiroyuki Ueno, Kosuke Matsubara, Sayuri Bou, Masato Hizume   +3 more
wiley   +1 more source

In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin

BMC Research Notes, 2018
Objective The rapid emergence of drug resistant Leishmanial strains makes it imperative to continue the development of cheap and effective drugs against the parasite.
Supriya Khanra, Y. Pavan Kumar, Jyotirmayee Dash, Rahul Banerjee   +3 more
doaj   +1 more source

Supramolecular assemblies of rifampicin and cationic bilayers: preparation, characterization and micobactericidal activity

BMC Biotechnology, 2011
Background Cationic bilayers based on the inexpensive synthetic lipid dioctadecyldimethylammonium bromide (DODAB) have been useful as carriers for drug delivery, immunoadjuvants for vaccines and active antimicrobial agents.
Mamizuka Elsa M, Barbassa Lilian, Carmona-Ribeiro Ana M   +2 more
doaj   +1 more source

Combined drug triads for synergic neuroprotection in retinal degeneration

Biomedicine & Pharmacotherapy, 2022
This review focuses on retina degeneration occurring during glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), and on the potential therapeutic use of triads of repositioned medicines, addressed to distinct but complementary targets, to prevent, delay or stop retina cell death.
Maneu, Victoria, Lax, Pedro, De Diego, Antonio Miguel G., Cuenca, Nicolás, García, Antonio G.   +4 more
openaire   +3 more sources

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Nature Communications, 2017
Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson, Curt A. Davey   +7 more
doaj   +1 more source