Results 31 to 40 of about 3,800,890 (227)

Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae

Emerging Microbes and Infections, 2020
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp).
Juan Bao, Nannan Wu, Yigang Zeng, Liguang Chen, Linlin Li, Lan Yang, Yiyuan Zhang, Mingquan Guo, Lisha Li, Jie Li, Demeng Tan, Meng-jun Cheng, J. Gu, J. Qin, Jiazhen Liu, Shiru Li, Guang-qiang Pan, Xin Jin, B. Yao, Xiaokui Guo, T. Zhu, Shuai Le   +21 more
semanticscholar   +1 more source

Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat

Pharmaceuticals, 2022
Pharmacological synergism is a current strategy for the treatment of pain. However, few studies have been explored to provide evidence of the possible synergism between a non-steroidal anti-inflammatory drug (NSAID) and a cannabinoid agonist, in order to
M. Irene Díaz-Reval, Yolitzy Cárdenas, Miguel Huerta, Xóchitl Trujillo, Enrique Alejandro Sánchez-Pastor, María Eva González-Trujano, Adolfo Virgen-Ortíz, M. Gicela Pérez-Hernández   +7 more
doaj   +1 more source

Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South
R. P. Mantovani, V. L. M. Rall, J. E. N. Batalha, A. A. H. Fernandes, A. Fernandes Junior   +4 more
doaj   +1 more source

Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)

Plants, 2021
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden.
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala   +14 more
doaj   +1 more source

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

Canadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin

BMC Research Notes, 2018
Objective The rapid emergence of drug resistant Leishmanial strains makes it imperative to continue the development of cheap and effective drugs against the parasite.
Supriya Khanra, Y. Pavan Kumar, Jyotirmayee Dash, Rahul Banerjee   +3 more
doaj   +1 more source

In vitro anti-proliferative effect of capecitabine (Xeloda) combined with mocetinostat (MGCD0103) in 4T1 breast cancer cell line by immunoblotting [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Mouse breast cancer cell line 4T1 can accurately mimic the response to immune receptors and targeting therapeutic agents. Combined therapy has emerged as an important strategy with reduced side effects and maximum therapeutic effect ...
Hacer Kaya Cakır, Onur Eroglu
doaj   +1 more source

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Nature Communications, 2017
Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson, Curt A. Davey   +7 more
doaj   +1 more source

Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Combination chemotherapy is a beneficial intervention for breast cancer, versus single therapy. We investigated the effect of Metformin (Met) on Lapatinib (Lap)-induced apoptosis in SK-BR3 cells.
Davood Neamati, Azam Khedri, Mohammad Aberomand, Ali-Asghar Hemati, Maryam Mohammadzadeh, Kourosh Akbari Baghbani, Ghorban Mohammadzadeh   +6 more
doaj   +1 more source

Combined drug triads for synergic neuroprotection in retinal degeneration

Biomedicine & Pharmacotherapy, 2022
This review focuses on retina degeneration occurring during glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), and on the potential therapeutic use of triads of repositioned medicines, addressed to distinct but complementary targets, to prevent, delay or stop retina cell death.
Maneu, Victoria, Lax, Pedro, De Diego, Antonio Miguel G., Cuenca, Nicolás, García, Antonio G.   +4 more
openaire   +3 more sources