Results 11 to 20 of about 881,158 (314)
Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury
Asian Journal of Pharmaceutical Sciences, 2023 Acute liver injury (ALI) has an elevated fatality rate due to untimely and ineffective treatment. Although, schisandrin B (SchB) has been extensively used to treat diverse liver diseases, its therapeutic efficacy on ALI was limited due to its high ...
Rongping Zhang +10 more
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Acta Pharmaceutica Sinica B, 2023 As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein
Fan Tong +11 more
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Acta Pharmaceutica Sinica B, 2023 Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide ...
Chuan Hu +8 more
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Mitochondria-Targeted Drugs [PDF]
Current Molecular Pharmacology, 2019 Background:Targeting of drugs to the subcellular compartments represents one of the modern trends in molecular pharmacology. The approach for targeting mitochondria was developed nearly 50 years ago, but only in the last decade has it started to become widely used for delivering drugs.
Zinovkin, Roman A., Zamyatnin, Andrey A.
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European Journal of Pharmaceutical Sciences, 2000 The main problems currently associated with systemic drug administration are: even biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a pathological site; the necessity of a large total dose of a drug to achieve high local concentration; non-specific toxicity and other adverse side-effects due to high drug
G. E. Francis, Cristina Delgado
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Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
Acta Pharmaceutica Sinica B, 2022 As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years.
Lei Wu +11 more
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Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment
Pharmaceutics, 2023 Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment.
Júlia German-Cortés +4 more
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Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Acta Pharmaceutica Sinica B, 2020 Chemotherapy agents have been widely used for cancer treatment, while the insolubility, instability and toxicity seriously restrict their efficacy. Thus, prodrug strategy was devised.
Rong Guo +6 more
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Molecular Therapy: Methods & Clinical Development, 2023 Following the recent approval of both siRNA- and mRNA-based therapeutics, nucleic acid therapies are considered a game changer in medicine. Their envisioned widespread use for many therapeutic applications with an array of cellular target sites means ...
Rasmus Münter +3 more
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Supramolecular nanomedicines based on host–guest interactions of cyclodextrins
Exploration, 2023 In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong +6 more
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