Results 11 to 20 of about 1,512,902 (358)

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

Studying how administration route and dose regulates antibody generation against LNPs for mRNA delivery with single-particle resolution

Molecular Therapy: Methods & Clinical Development, 2023
Following the recent approval of both siRNA- and mRNA-based therapeutics, nucleic acid therapies are considered a game changer in medicine. Their envisioned widespread use for many therapeutic applications with an array of cellular target sites means ...
Rasmus Münter, Esben Christensen, Thomas L. Andresen, Jannik B. Larsen   +3 more
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L., Goltsov, Alexey, Goltsov, Gregory, Harrison, David J., Langdon, Simon P.   +4 more
core   +5 more sources

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Exploration, 2023
In the biomedical and pharmaceutical fields, cyclodextrin (CD) is undoubtedly one of the most frequently used macrocyclic compounds as the host molecule because it has good biocompatibility and can increase the solubility, bioavailability, and stability ...
Fan Tong, Yang Zhou, Yanyan Xu, Yuxiu Chen, Natalia Yudintceva, Maxim Shevtsov, Huile Gao   +6 more
doaj   +1 more source

Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland

Scientific Reports, 2017
Transporters involved in bile acid (BA) handling by the mammary gland are poorly understood. Here we have investigated the role of ABC proteins in blood-milk BA traffic and its sensitivity to maternal cholestasis. BA concentrations in rat and mouse serum
Alba M. G. Blazquez, Rocio I. R. Macias, Candela Cives-Losada, Alberto de la Iglesia, Jose J. G. Marin, Maria J. Monte   +5 more
doaj   +1 more source

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

Journal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke, Han Guo, Xi Zhu, Yun Jin, Yuan Huang   +4 more
doaj   +1 more source

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

Acta Pharmaceutica Sinica B, 2019
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight ...
Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li, Qin He   +9 more
doaj   +1 more source

Chemical approaches to targeting drug resistance cancer stem cells [PDF]

, 2016
STEMCHEM is a COST action aiming to target causes of drug resistance in cancer stem cells. Cancer stem cells are cells which are believed to be responsible for the larger part of the regenerative capacity of cancers.
Blaire Theuma, Krystle, Cassar, Analisse, Micallef, Neville, Passarella, Daniele, Schembri-Wismayer, Pierre, Stipourou, Iona, Suleiman, Sherif   +6 more
core   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]

, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu, Dowdy, Steven F, Huggins, Ian J, Jadhav, Satish, Medina, Carlos A, Springer, Aaron D, van den Berg, Arjen   +6 more
core   +1 more source

Recent Progress in Gas Sensors Based on P3HT Polymer Field-Effect Transistors

Sensors, 2023
In recent decades, the rapid development of the global economy has led to a substantial increase in energy consumption, subsequently resulting in the emission of a significant quantity of toxic gases into the environment.
Si Cheng, Yifan Wang, Ruishi Zhang, Hongjiao Wang, Chenfang Sun, Tie Wang   +5 more
doaj   +1 more source