Results 1 to 10 of about 619,603 (116)

Role of gemcitabine in the treatment of advanced and metastatic breast cancer [PDF]

, 2003
Gemcitabine is an antimetabolite drug with proven antitumor activity and tolerability in metastatic breast cancer. In a total of nine studies, gemcitabine monotherapy has reached response rates of up to 37% in the first-line setting, 26% in the second ...
Heinemann, Volker
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Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2017
An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Han, Qinghong, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miyake, Kentaro, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Tan, Yuying, Unno, Michiaki   +15 more
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Arterial anatomy and arteriographic diagnosis of arteriogenic impotence [PDF]

, 1988
One hundred twenty-six bilateral selective arteriographic examinations of the iliopudendal vascular tree were performed after comprehensive multidisciplinary evaluation in patients with chronic erectile dysfunction.
Bähren, Wolfgang, Gall, Helmut, Scherb, Wolfgang, Stief, Christian Georg, Thon, Walter F.   +4 more
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Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]

, 2017
Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George, Deedwania, Prakash, Reimitz, Paul-Egbert, Weber, Michael   +3 more
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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. [PDF]

, 2016
BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines ...
Al-Awar, Rima, Babichev, Yael, Boutros, Paul C, Datti, Alessandro, Dickson, Brendan C, Gladdy, Rebecca A, Isaac, Methvin, Kabaroff, Leah, Prakesch, Michael, Sun, Ren X, Uehling, David, Venier, Rosemarie   +11 more
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Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar, Klose, Christina, Kouyaté, Bocar, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Sié, Ali, Walter-Sack, Ingeborg, Zoungrana, Augustin   +10 more
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The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

BMC Cancer, 2020
Background Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in other areas for preventing drug ...
H. Jonathan G. Lindström, Ran Friedman
doaj   +1 more source

A prospective randomized trial of tacrolimus and prednisone versus tacrolimus, prednisone, and mycophenolate mofetil in primary adult liver transplant recipients: An interim report [PDF]

, 1998
Background. Tacrolimus (Tac) and mycophenolate mofetil (MMF) are newly approved immunosuppressive agents. However, the safety and efficacy of the combination of MMF and Tac in primary liver transplantation has not been determined. Methods.
Demetris, J, Dodson, F, Fung, JJ, Hamad, I, Jain, AB, Kramer, D, Mcmichael, J, Rakela, J, Starzl, TE   +8 more
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Evaluation of the efficacy of Q-switched ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To observe the efficacy of Q switch ruby laser combined with tranexamic acid for melasma and its effects on melanin metabolism. Methods A total of 60 patients with melasma were divided into three groups: Drug group (oral tranexamic acid 500 mg ...
Hua LI, Yiyu ZHAO, Yating HU, Yong HAO, Hui HAN   +4 more
doaj   +1 more source

Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extension [PDF]

Diabetes & Metabolism Journal, 2023
Background This study investigates the long-term efficacy and safety of evogliptin add-on therapy in patients with inadequately controlled type 2 diabetes mellitus (T2DM) previously received dapagliflozin and metformin (DAPA/MET) combination.
Jun Sung Moon, Il Rae Park, Hae Jin Kim, Choon Hee Chung, Kyu Chang Won, Kyung Ah Han, Cheol-Young Park, Jong Chul Won, Dong Jun Kim, Gwan Pyo Koh, Eun Sook Kim, Jae Myung Yu, Eun-Gyoung Hong, Chang Beom Lee, Kun-Ho Yoon   +14 more
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