Results 1 to 10 of about 784,830 (310)

The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model

Microorganisms, 2023
Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng, Dong Yang, Céline Rens, Véronique Fontaine   +3 more
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Clinical study of dynamic changes of cerebrospinal fluid cytology in drug resistant tuberculous meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong, KUANG Wei⁃feng , ZHANG Li⁃ting, ZHOU Li, ZHAO Si⁃qi , DUAN Hong⁃fei, XIE Jia , JIN Yan , CHEN Hai⁃ying , YE Lin , ZHANG Qi⁃long   +10 more
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The Resolution of the Russian League Against Epilepsy Working Group Meeting (September 25, 2021, Moscow)

Эпилепсия и пароксизмальные состояния, 2022
On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
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Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
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Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

mSystems, 2023
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler   +6 more
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Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Frontiers in Oncology, 2023
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu   +7 more
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Non-walled spherical Acinetobacter baumannii is an important type of persister upon β-lactam antibiotic treatment

Emerging Microbes and Infections, 2020
Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou, Si-Hoi Kou, Ruiqiang Xie, Michael S. VanNieuwenhze, Jiuxin Qu, Bo Peng, Jun Zheng   +6 more
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Impact of the CYP2D6 Genotype on Metoprolol Tolerance and Adverse Events in Elderly Chinese Patients With Cardiovascular Diseases

Frontiers in Pharmacology, 2022
The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen, Jianqiao Chen, Jin Zheng, Zifan Zhu, Zifan Zhu, Benchuan Hao, Benchuan Hao, Miao Wang, Huiying Li, Huiying Li, Yulun Cai, Yulun Cai, Shiqi Wang, Jun Li, Hongbin Liu   +14 more
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Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

eLife, 2023
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux, Samira Massahi, Van Bettauer, Austin Mottola, Anna Dukovny, Sanny Singh Khurdia, Anna Carolina Borges Pereira Costa, Raha Parvizi Omran, Shawn Simpson, Jinglin Lucy Xie, Malcolm Whiteway, Judith Berman, Michael T Hallett   +12 more
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VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

Frontiers in Microbiology, 2020
The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma, Gopinath Chattopadhyay, Pankaj Chopra, Munmun Bhasin, Chandrani Thakur, Sakshi Agarwal, Shahbaz Ahmed, Nagasuma Chandra, Raghavan Varadarajan, Raghavan Varadarajan, Ramandeep Singh   +10 more
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