Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Combination therapy is necessary to treat tuberculosis to decrease the rate of disease relapse and prevent the acquisition of drug resistance, and shorter regimens are urgently needed.
Talia Greenstein +5 more
doaj +3 more sources
The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis [PDF]
mBio, 2022 Mycobacterium tuberculosis can cocatabolize a range of carbon sources. Fatty acids are among the carbons available inside the host’s macrophages. Here, we investigated the metabolic changes of the fatty acid-induced dormancy-like state of M. tuberculosis
Camila G. Quinonez +7 more
doaj +3 more sources
Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Suboptimal efficacy of the current antibiotic regimens and frequent emergence of antibiotic-resistant Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), render TB the world’s deadliest infectious disease before the COVID-19 ...
Hyungjin Eoh +4 more
doaj +3 more sources
Extreme Drug Tolerance of Mycobacterium abscessus “Persisters” [PDF]
Frontiers in Microbiology, 2020 Persistence of infection despite extensive chemotherapy with antibiotics displaying low MICs is a hallmark of lung disease caused by Mycobacterium abscessus (Mab). Thus, the classical MIC assay is a poor predictor of clinical outcome.
Yee-Kuen Yam +5 more
doaj +3 more sources
VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis [PDF]
Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +3 more sources
The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress. [PDF]
PLoS Pathog, 2023 Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Yau KPS +7 more
europepmc +2 more sources
Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance. [PDF]
Front Cell Infect Microbiol, 2022 Treatment of Mycobacterium tuberculosis (Mtb) infections is particularly arduous. One challenge to effectively treating tuberculosis is that drug efficacy in vivo often fails to match drug efficacy in vitro.
Samuels AN +4 more
europepmc +2 more sources
Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse. [PDF]
J Clin Invest, 2022 Although first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy is effective for treating EGFR-mutant non–small cell lung cancer (NSCLC), it is now understood that drug-tolerant persister (DTP) cells escaping from ...
Nie M +12 more
europepmc +2 more sources
Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance. [PDF]
mBio, 2022 Tuberculosis is unusual among bacterial diseases in that treatments which can rapidly resolve symptoms do not predictably lead to a durable cure unless treatment is continued for months after all clinical and microbiological signs of disease have been ...
Sebastian J +8 more
europepmc +2 more sources
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance. [PDF]
Nat Microbiol, 2022 Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs for amino acid biosynthesis pathways in microbiome data derived from >12 ...
Yu JSL +18 more
europepmc +2 more sources