Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance. [PDF]
Nat Microbiol, 2022 Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs for amino acid biosynthesis pathways in microbiome data derived from >12 ...
Yu JSL +18 more
europepmc +2 more sources
Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis. [PDF]
PLoS Pathog, 2022 Despite the existence of well-characterized, canonical mutations that confer high-level drug resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance mechanisms are more complex than simple acquisition of such mutations ...
Martini MC +7 more
europepmc +2 more sources
Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis. [PDF]
Nat Commun, 2021 Tuberculosis is a chronic disease that displays several features commonly associated with biofilm-associated infections: immune system evasion, antibiotic treatment failures, and recurrence of infection. However, although Mycobacterium tuberculosis (Mtb)
Chakraborty P +4 more
europepmc +2 more sources
p53 mutations define the chromatin landscape to confer drug tolerance in pancreatic cancer. [PDF]
Mol Oncol, 2022 Somatic inactivation of p53 (TP53) mainly occurs as missense mutations that lead to the acquisition of neomorphic mutant protein forms. p53 mutants have been postulated to exert gain‐of‐function (GOF) effects, including promotion of metastasis and drug ...
Zampieri C +5 more
europepmc +2 more sources
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line [PDF]
Nature Communications, 2020 The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging ...
Yapeng Su +22 more
openalex +2 more sources
Drug Tolerance to EGFR Tyrosine Kinase Inhibitors in Lung Cancers with EGFR Mutations. [PDF]
Cells, 2021 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) serve as the standard of care for the first-line treatment of patients with lung cancers with EGFR-activating mutations.
Suda K, Mitsudomi T.
europepmc +2 more sources
Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Nonreplicating (NR) Mycobacterium tuberculosis (Mtb) was thought to be drug tolerant due to its low metabolic activity. However, drug tolerance often gradually increases by exposure to antibiotics, inferring the role of an adaptive strategy.
Lim J +5 more
europepmc +2 more sources
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer. [PDF]
Nat Commun, 2021 Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases.
Aissa AF +14 more
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Frontiers in Microbiology, 2020 The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M. tuberculosis genome.
Arun Sharma +10 more
doaj +2 more sources
CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma. [PDF]
EMBO Rep, 2021 Melanoma cell phenotype switching between differentiated melanocytic and undifferentiated mesenchymal‐like states drives metastasis and drug resistance. CDK7 is the serine/threonine kinase of the basal transcription factor TFIIH.
Berico P +13 more
europepmc +2 more sources