Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis. [PDF]
PLoS Pathog, 2022 Despite the existence of well-characterized, canonical mutations that confer high-level drug resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance mechanisms are more complex than simple acquisition of such mutations ...
Martini MC +7 more
europepmc +2 more sources
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance. [PDF]
Nat Commun, 2022 Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance.
Therizols G +31 more
europepmc +2 more sources
Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis. [PDF]
Nat Commun, 2021 Tuberculosis is a chronic disease that displays several features commonly associated with biofilm-associated infections: immune system evasion, antibiotic treatment failures, and recurrence of infection. However, although Mycobacterium tuberculosis (Mtb)
Chakraborty P +4 more
europepmc +2 more sources
Drug Tolerance to EGFR Tyrosine Kinase Inhibitors in Lung Cancers with EGFR Mutations. [PDF]
Cells, 2021 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) serve as the standard of care for the first-line treatment of patients with lung cancers with EGFR-activating mutations.
Suda K, Mitsudomi T.
europepmc +2 more sources
Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans. [PDF]
mBio, 2021 Candida albicans is a prevalent human fungal commensal and also a pathogen that causes life-threatening systemic infections. Treatment failures are frequent because few therapeutic antifungal drug classes are available and because drug resistance and ...
Yang F +7 more
europepmc +2 more sources
Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of Mycobacterium tuberculosis in hypoxia. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Nonreplicating (NR) Mycobacterium tuberculosis (Mtb) was thought to be drug tolerant due to its low metabolic activity. However, drug tolerance often gradually increases by exposure to antibiotics, inferring the role of an adaptive strategy.
Lim J +5 more
europepmc +2 more sources
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer. [PDF]
Nat Commun, 2021 Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases.
Aissa AF +14 more
europepmc +2 more sources
CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma. [PDF]
EMBO Rep, 2021 Melanoma cell phenotype switching between differentiated melanocytic and undifferentiated mesenchymal‐like states drives metastasis and drug resistance. CDK7 is the serine/threonine kinase of the basal transcription factor TFIIH.
Berico P +13 more
europepmc +2 more sources
The Mycobacterial Efflux Pump EfpA Can Induce High Drug Tolerance to Many Antituberculosis Drugs, Including Moxifloxacin, in Mycobacterium smegmatis. [PDF]
Antimicrob Agents Chemother, 2021 Active efflux of drugs across the membrane is a major survival strategy of bacteria against many drugs. In this work, we characterize an efflux pump, EfpA, from the major facilitator superfamily, that is highly conserved among both slow-growing and fast ...
Rai D, Mehra S.
europepmc +2 more sources
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans [PDF]
Frontiers in MicrobiologyBackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng +3 more
doaj +2 more sources