Drug resistance and tolerance in fungi
Nature Reviews Microbiology, 2020 Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug.
Judith Berman, Damian J. Krysan
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Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis. [PDF]
Sci Transl Med, 2019 Chloroquine resets the redox physiology of Mycobacterium tuberculosis to potentiate the efficacy of antibiotics in vivo. Antibiotic redox-based redux Phagosomal pH and redox heterogeneity in Mycobacterium tuberculosis (Mtb) can promote tolerance of the ...
Mishra R +12 more
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Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance The ability of Mycobacterium tuberculosis to survive during prolonged treatment has been attributed to either transient stress responses or fixed heritable drug-resistance–producing mutations.
Safi H +16 more
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Dysosmia and drug tolerance with use of venlafaxine. [PDF]
BMJ Case Rep, 2021 A 57-year-old woman presented with a 1-year history of major depressive disorder. She was started on venlafaxine XR 75 mg orally daily and a few days later developed severe dysosmia to foods she used to enjoy. She never had previous problems with smell or taste. At her 1-month follow-up, her depressive symptoms had improved, but she reported persistent
Rousseau C, Malaty J.
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Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance. [PDF]
Sci Signal, 2019 Resistance to unrelated chemotherapeutics in breast cancer cells is caused by a metabolic switch. Metabolic remodeling for drug resistance Commonly used chemotherapies can lead to resistance to drugs with different modes of actions.
Goldman A +15 more
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Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance. [PDF]
Antimicrob Agents Chemother, 2019 Mycobacterium tuberculosis spontaneously grows at the air-medium interface, forming pellicle biofilms, which harbor more drug-tolerant persisters than planktonic cultures. The underlying basis for increased persisters in M.
Richards JP +4 more
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Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis [PDF]
Nature Communications, 2019 Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level of antibiotic-tolerance and serves as a source of multidrug-resistant (MDR) mutations.
Jae Jin Lee +8 more
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Drug-induced epigenetic changes produce drug tolerance. [PDF]
PLoS Biology, 2007 Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural ...
Yan Wang +4 more
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mBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang +7 more
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Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria. [PDF]
Sci Rep, 2019 Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb), the etiologic
Santucci P +7 more
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