Extracellular DNA of slow growers of mycobacteria and its contribution to biofilm formation and drug tolerance. [PDF]
Sci Rep, 2021 DNA is basically an intracellular molecule that stores genetic information and carries instructions for growth and reproduction in all cellular organisms.
Ilinov A +14 more
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Decoding drug tolerance: insights into the Rv0274 gene's role in isoniazid tolerance [PDF]
Frontiers in MicrobiologyIntroductionIsoniazid is widely used in the treatment of pulmonary tuberculosis, yet the mechanisms underlying its tolerance remain incompletely understood.
Min Li +10 more
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Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans [PDF]
Frontiers in MicrobiologyBackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng +3 more
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Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria [PDF]
Scientific Reports, 2019 Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb), the etiologic
Pierre Santucci +7 more
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Drug resistance and tolerance in fungi
Nature Reviews Microbiology, 2020 Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug.
Judith Berman, Damian J. Krysan
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Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo [PDF]
Journal of Experimental Medicine, 2016 Russell et al. show that activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Yan‐Cheng Liu +9 more
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The Potential Links between lncRNAs and Drug Tolerance in Lung Adenocarcinoma. [PDF]
Genes (Basel)Davis WJH +3 more
europepmc +3 more sources
The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model
Microorganisms, 2023 Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng +3 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong +10 more
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Эпилепсия и пароксизмальные состояния, 2022 On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
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