Results 31 to 40 of about 5,099,978 (377)
'Zero tolerance' and drug education in Australian schools [PDF]
, 2000 For a decade in Australia, drug education in schools has been shaped by the approach of harm minimization adopted by state and national governments alike. Harm minimization has been accepted broadly by drug educators, and has encouraged schools to deepen
Geoffrey D. Munro, Richard Midford
core +4 more sources
Sensitivity and Drug Tolerance of Antidrug Antibody Assays in Relation to Positive Control Characteristics [PDF]
Bioanalysis, 2018 AIM Detection and characterization of antidrug antibodies (ADA) play a key role in understanding the relation of ADA with safety and efficacy. Positive controls (PCs) are used to estimate the sensitivity and assay sensitivity in the presence of drug ...
David Egging +8 more
openalex +2 more sources
Clinical Ophthalmology, 2018 Purpose To investigate whether tolerance to the anti-VEGF drug, ranibizumab, develops after drug exposure and to determine whether the history of treatment with ranibizumab prior to refractoriness can predict the post-switching responses to aflibercept ...
Ali Dirani, Irmela Mantel
openalex +3 more sources
Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor (VEGF) injections to treat neovascular age-related macular degeneration (nAMD) with subretinal fluid (SRF) and pigment epithelial ...
Bo Hee Kim +3 more
doaj +1 more source
Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
Frontiers in Pediatrics, 2021 Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce.
Justyna Sieber +4 more
doaj +1 more source
Efficacy and tolerability of antiseizure drugs [PDF]
Therapeutic Advances in Neurological Disorders, 2021 Drug-resistant epilepsy occurs in 25–30% of patients. Furthermore, treatment with a first-generation antiseizure drug (ASD) fails in 30–40% of individuals because of their intolerable adverse effects. Over the past three decades, 20 newer- (second- and third-)generation ASDs with unique mechanisms of action and pharmacokinetic profiles have been ...
openaire +3 more sources
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications.
Marlene Jara +6 more
doaj +1 more source
The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Frontiers in Genetics, 2023 Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with ...
Biqing Chen +3 more
doaj +1 more source
A mathematical model of reward-mediated learning in drug addiction [PDF]
Chaos 32, 021102 (2022), 2022 Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error (RPE), drug-induced incentive salience (IST), and opponent process ...
arxiv +1 more source
Microorganisms, 2023 Mycobacterium abscessus has recently emerged as the cause of an increasing number of human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new specific agents to combat M. abscessus have not yet been found.
Andrey L. Mulyukin +7 more
doaj +1 more source