Results 31 to 40 of about 4,947,330 (332)

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

mSystems, 2023
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler   +6 more
doaj   +1 more source

Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Frontiers in Oncology, 2023
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu   +7 more
doaj   +1 more source

Non-walled spherical Acinetobacter baumannii is an important type of persister upon β-lactam antibiotic treatment

Emerging Microbes and Infections, 2020
Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou, Si-Hoi Kou, Ruiqiang Xie, Michael S. VanNieuwenhze, Jiuxin Qu, Bo Peng, Jun Zheng   +6 more
doaj   +1 more source

Impact of the CYP2D6 Genotype on Metoprolol Tolerance and Adverse Events in Elderly Chinese Patients With Cardiovascular Diseases

Frontiers in Pharmacology, 2022
The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen, Jianqiao Chen, Jin Zheng, Zifan Zhu, Zifan Zhu, Benchuan Hao, Benchuan Hao, Miao Wang, Huiying Li, Huiying Li, Yulun Cai, Yulun Cai, Shiqi Wang, Jun Li, Hongbin Liu   +14 more
doaj   +1 more source

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

eLife, 2023
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux, Samira Massahi, Van Bettauer, Austin Mottola, Anna Dukovny, Sanny Singh Khurdia, Anna Carolina Borges Pereira Costa, Raha Parvizi Omran, Shawn Simpson, Jinglin Lucy Xie, Malcolm Whiteway, Judith Berman, Michael T Hallett   +12 more
doaj   +1 more source

Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration [PDF]

International Journal of Ophthalmology, 2023
AIM: To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor (VEGF) injections to treat neovascular age-related macular degeneration (nAMD) with subretinal fluid (SRF) and pigment epithelial ...
Bo Hee Kim, In Boem Chang, Hyeong Gon Yu, In Hwan Hong   +3 more
doaj   +1 more source

A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris. [PDF]

Infect Immun
Yang B, Vaisvil B, Schmitt D, Collins J, Young E, Kapatral V, Rao R.   +6 more
europepmc   +2 more sources

Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years

Frontiers in Pediatrics, 2021
Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce.
Justyna Sieber, Justyna Sieber, Sabine Renner, Andrea Lakatos-Krepcik, Zsolt Szépfalusi   +4 more
doaj   +1 more source

The Mycobacterial Efflux Pump EfpA Can Induce High Drug Tolerance to Many Antituberculosis Drugs, Including Moxifloxacin, in Mycobacterium smegmatis

Antimicrobial Agents and Chemotherapy, 2021
Active efflux of drugs across the membrane is a major survival strategy of bacteria against many drugs. In this work, we characterize an efflux pump, EfpA, from the major facilitator superfamily, that is highly conserved among both slow-growing and fast ...
Deepika Rai, Sarika Mehra
semanticscholar   +1 more source