Results 41 to 50 of about 4,947,330 (332)
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionResistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications.
Marlene Jara +6 more
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Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
Frontiers in Microbiology, 2020 Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze +13 more
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The recent advancements of ferroptosis in the diagnosis, treatment and prognosis of ovarian cancer
Frontiers in Genetics, 2023 Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with ...
Biqing Chen +3 more
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Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
Microbial Cell, 2022 Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host’s fatty acids as a main carbon source ...
Camila G. Quinonez +7 more
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Microorganisms, 2023 Mycobacterium abscessus has recently emerged as the cause of an increasing number of human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new specific agents to combat M. abscessus have not yet been found.
Andrey L. Mulyukin +7 more
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Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
eLife, 2020 Previously, we identified long repeat sequences that are frequently associated with genome rearrangements, including copy number variation (CNV), in many diverse isolates of the human fungal pathogen Candida albicans (Todd et al., 2019).
Robert T Todd, Anna Selmecki
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Microbiology Spectrum, 2022 The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang +3 more
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Frontiers in Microbiology, 2020 Bacterial persistence has become a worldwide health problem due to its ability to cause the recalcitrance and relapse of infections. The existence of bacterial persistence and their possible mechanisms have been widely reported.
Junzhuo Lu +9 more
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Tolerability of Antimalaria Drugs [PDF]
Clinical Infectious Diseases, 2002 Sir—The multicenter randomized trial reported by Overbosch and colleagues [1] is important for 2 reasons. First, the study shows that when taken as malaria prophylaxis, mefloquine is not well tolerated by many travelers. Of the study participants randomized to receive mefloquine, 67.1% reported 1 adverse event, and, in 6% of mefloquine users, these ...
Ashley M. Croft, Andrew Herxheimer
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Frontiers in Oncology, 2022 BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang +8 more
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