Results 41 to 50 of about 5,099,978 (377)
eLife, 2023 Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux +12 more
doaj +1 more source
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
eLife, 2020 Previously, we identified long repeat sequences that are frequently associated with genome rearrangements, including copy number variation (CNV), in many diverse isolates of the human fungal pathogen Candida albicans (Todd et al., 2019).
Robert T Todd, Anna Selmecki
doaj +1 more source
Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
Microbial Cell, 2022 Unlike other heterotrophic bacteria, Mycobacterium tuberculosis (Mtb) can co-catabolize a range of carbon sources simultaneously. Evolution of Mtb within host nutrient environment allows Mtb to consume the host’s fatty acids as a main carbon source ...
Camila G. Quinonez +7 more
doaj +1 more source
Tolerability of Antimalaria Drugs [PDF]
Clinical Infectious Diseases, 2002 Sir—The multicenter randomized trial reported by Overbosch and colleagues [1] is important for 2 reasons. First, the study shows that when taken as malaria prophylaxis, mefloquine is not well tolerated by many travelers. Of the study participants randomized to receive mefloquine, 67.1% reported 1 adverse event, and, in 6% of mefloquine users, these ...
Andrew Herxheimer, Ashley M Croft
openaire +2 more sources
Frontiers in Microbiology, 2020 Bacterial persistence has become a worldwide health problem due to its ability to cause the recalcitrance and relapse of infections. The existence of bacterial persistence and their possible mechanisms have been widely reported.
Junzhuo Lu +9 more
doaj +1 more source
Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis
Proceedings of the National Academy of Sciences of the United States of America, 2017 Catherine Vilchèze +7 more
openalex +2 more sources
Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori
JGH Open, 2021 Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad +5 more
doaj +1 more source
Large-Scale Data Mining of Rapid Residue Detection Assay Data From HTML and PDF Documents: Improving Data Access and Visualization for Veterinarians [PDF]
8, 2021, 13, 2021 Extra-label drug use in food animal medicine is authorized by the US Animal Medicinal Drug Use Clarification Act (AMDUCA), and estimated withdrawal intervals are based on published scientific pharmacokinetic data. Occasionally there is a paucity of scientific data on which to base a withdrawal interval or a large number of animals being treated ...
arxiv +1 more source
Frontiers in Oncology, 2022 BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang +8 more
doaj +1 more source
eLife, 2017 Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra +10 more
doaj +1 more source