The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model
Microorganisms, 2023 Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein
Sheng Zeng +3 more
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Drug Tolerance in Mycobacterium tuberculosis [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Although Mycobacterium tuberculosis is eradicated rapidly during therapy in some patients with pulmonary tuberculosis, it can persist for many months in others. This study examined the relationship between mycobacterial drug tolerance (delayed killing in vitro), persistence, and relapse.
Seon Hee Cheon +15 more
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Depth of anesthesia control using internal model control techniques [PDF]
, 2010 The major difficulty in the design of closed-loop control during anaesthesia is the inherent patient variability due to differences in demographic and drug tolerance.
Anna, Shahab, Wen, Peng
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Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review
Frontiers in Oncology, 2023 Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang +7 more
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Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis
Microbiology Spectrum, 2021 Candida parapsilosis is an emerging major human fungal pathogen, especially in neonates. Aneuploidy, having uneven numbers of chromosomes, is a well-known mechanism for adapting to stress in Candida albicans , the most common human fungal pathogen.
Hao Wu +6 more
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Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]
, 2008 Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Casalotti, Stefano O. +3 more
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Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings
Veterinary Sciences, 2022 Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann +8 more
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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. [PDF]
, 2019 Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance.
A Hübner +66 more
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Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance
bioRxiv, 2020 Partial response to chemotherapy leads to disease resurgence. Upon treatment, a subpopulation of cancer cells, called drug-tolerant persistent cells, display a transitory drug tolerance that lead to treatment resistance 1,2.
Gabriel Thérizols +31 more
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Эпилепсия и пароксизмальные состояния, 2022 On September 25, 2021, the Russian League Against Epilepsy (RLAE) Working Group Meeting was held regarding approaches to therapy of pediatric focal epilepsy.
article Editorial
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