Results 41 to 50 of about 6,370 (180)

Effects of desulfurized gypsum on shrinkage behavior of alkali-activated slag (AAS) and hybrid alkali-activated cement (HAC)

Case Studies in Construction Materials
This study reports the use of desulfurized gypsum (DSG) to mitigate the shrinkage problem of two typical alkali-activated materials (AAMs), i.e. alkali-activated slag (AAS) and hybrid alkali-activated cement (HAC).
Lili Xue, Zhenkun Ni, Zhengning Zhou, Zuhua Zhang, Houren Xiong, Hao Wang, Xifeng Zhuge, Hongfei Liu   +7 more
doaj   +1 more source

Short-term clinical and serological follow-up with conventional and conformational anti-desmoglein antibodies in treatment-naïve and previously treated patients with pemphigus vulgaris after receiving rituximab

International Journal of Women's Dermatology, 2019
Background: Pemphigus vulgaris (PV) is a blistering, life-threatening autoimmune disease. Ethylenediaminetetraacetic acid (EDTA)-treated desmoglein (Dsg) enzyme-linked immunosorbent assay (ELISA) has recently been suggested to detect nonpathogenic ...
Hoorieh Alaeen, MD, Roja Toosi, MD, MPH, Hamidreza Mahmoudi, MD, Kamran Balighi, MD, Soheil Tavakolpour, MS, Amir Teimoupour, PhD, Maryam Daneshpazhooh, MD   +6 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Diclofenac Sodium Topical Gel (DSG) 1% Reduces Swelling and Tenderness and Improves Ankle Joint Function in Subjects with Acute Ankle Sprain: A Randomized, Double-Blind, Placebo-Controlled Trial

Orthopaedic Journal of Sports Medicine, 2013
Objectives: Ankle sprains are among the most common sports-related injuries and are often self-treated. Over-the-counter treatment options known to reduce pain and inflammation, such as oral non-steroidal anti-inflammatory drugs (NSAIDs), may be ...
Hans-Georg Predel MD, Bruno Giannetti MD, PhD   +1 more
doaj   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity

Small, EarlyView.
Lipid nanoparticle composition governs distinct cytokine programs through the interplay of ionizable and polyethylene glycol‐conjugated (PEGylated) lipids. In vitro profiling, design of experiments (DoE) modeling, and in vivo validation reveal how formulation can tune reactogenicity‐associated pathways, while transgene expression remains the strongest ...
Adam Alexander Walters, Belal I. Hanafy, Chuan‐En Lu, Sara Marelli, Alaa Zam, Kai Liu, Rachel E. Foreman, Ramesh Soundararajan, Philippe Collin, Lennart Lindfors, Alan Sabirsh, Mariarosa Mazza, Khuloud T. Al‐Jamal, Stephanie M. Bates, George Thom, Jan Rehwinkel, Alexander N Kapustin   +16 more
wiley   +1 more source

Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen

Frontiers in Immunology, 2019
Pemphigus Vulgaris is an autoimmune disease of the skin and mucous membranes, which is due to the production of pathogenic autoantibodies targeting desmoglein (DSG) 1 and 3, which are adhesion proteins of the keratinocytes.
Vivien Hébert, Vivien Hébert, Marie Petit, Maud Maho-Vaillant, Maud Maho-Vaillant, Marie-Laure Golinski, Marie-Laure Golinski, Gaëtan Riou, Céline Derambure, Olivier Boyer, Pascal Joly, Pascal Joly, Sébastien Calbo   +12 more
doaj   +1 more source

Dipeptidyl Peptidase‐4 Inhibitor Use and Risk of Pemphigus Vulgaris and Foliaceus: A Retrospective Cohort Study Using Databases of the Korea National Health Insurance Claims and the National Health Screening Examination

The Journal of Dermatology, EarlyView.
ABSTRACT Although population‐based studies have reported an increased risk of bullous pemphigoid and pemphigus associated with dipeptidyl peptidase‐4 (DPP‐4) inhibitors, there is limited, well‐designed epidemiological evidence for pemphigus vulgaris (PV), which has only been supported by case reports thus far.
Jaein Lee, Jae Hyun Bae, Seokyung Hahn
wiley   +1 more source

Diosgenin alleviates D-galactose-induced oxidative stress in rats’ brain and liver targeting aging and apoptotic marker genes

Frontiers in Molecular Biosciences
The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants.
Ali H. El-Far, Mona M. Elghaity, Shymaa A. Mohamed, Ahmed E. Noreldin, Yaser H. A. Elewa, Yaser H. A. Elewa, Soad Khalil Al Jaouni, Abdelwahab A. Alsenosy   +7 more
doaj   +1 more source

Pemphigus Vulgaris: Application of Occlusal Soft Splint with Topical Steroid in the Treatment

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatosis with a high mortality rate if untreated. It is characterized by the binding of IgG autoantibodies to desmogleins 3 (DSG 3), a transmembrane glycoprotein adhesion molecule present on ...
G Vivekanandh Reddy, G Ramlal, K Jitendar Reddy, K Swetha, A Madhavi   +4 more
doaj   +1 more source