Results 191 to 200 of about 73,913 (251)

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity. [PDF]

Nat Commun
Sanchez-David RY, Nemegeer J, Le HD, Žusinaite E, Spiga L, Gonçalves A, Tregoning JS, Merits A, Maillard PV.   +8 more
europepmc   +1 more source

Multimodal targets of (‐)‐α‐thujone mediating avoidance behavior of a stored‐products pest, Tribolium castaneum, in response to irritant stimuli

Pest Management Science, Volume 82, Issue 10, Page 9592-9598, October 2026.
We identified four kinds of target molecules against (‐)‐α‐thujone associating avoidance behavior in Tribolium castaneum, indicating multimodality. Abstract BACKGROUND The reciprocal evolutionary processes among phytophagous insects and host plants involve host shift in the herbivorous insects in response to defense chemicals, such as plant‐derived ...
Kenji Shimomura, Yuto Suzuki, Soshi Ino, Takehito Terajima, Motohiro Tomizawa   +4 more
wiley   +1 more source

Spray-Induced Gene Silencing (SIGS) of Dual-Target Genes (<i>AaGH10</i> and <i>AaSOD</i>) Enhances Control of <i>Alternaria alternata</i> White Leaf Spot in Chinese Chive. [PDF]

J Fungi (Basel)
Wang L, Huang K, Gou Y, Zhu Y, Zhao M, Liao C, Zhang H, Ma P, Wang Z, Zhu T, Li T.   +10 more
europepmc   +1 more source

Identification of broadly expressed nervous system‐related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys

Pest Management Science, Volume 82, Issue 10, Page 9870-9878, October 2026.
Broadly expressed genes outperformed brain‐enriched neural targets as RNAi candidates in Halyomorpha halys. Microinjection of dsRNA targeting alpha‐soluble NSF attachment protein (Asnap) or Ras opposite protein (Rop) caused strong feeding suppression and near‐complete mortality, identifying them as promising targets for future oral or spray‐based RNAi ...
Nirakar Panda, Aline Koch, Venkata Partha Sarathi Amineni   +2 more
wiley   +1 more source

Dose‐dependent efficacy of a novel dsRNA‐based solution containing vadescana for Varroa destructor control

Pest Management Science, Volume 82, Issue 10, Page 9974-9983, October 2026.
Vadescana is a novel dsRNA‐based product that targets Varroa fecundity. Vadescana applied at 4 g/brood box in one application was most effective at reducing Varroa populations for up to 18 weeks. Abstract BACKGROUND A novel dsRNA‐based product, containing a molecule called vadescana, interferes with Varroa destructor (Anderson and Trueman) fecundity ...
Briana E Price, Ryan Kuesel, Taylor Reams, Brian Manley, James Masucci, Brandon K Hopkins   +5 more
wiley   +1 more source

Screening, optimization and artificial recombination of dsRNA fragments for RNAi-mediated pest resistance in <i>Apolygus lucorum</i>. [PDF]

Front Insect Sci
Luo J, Guo Q, Hu R, Zhang M, Wang G, Yang B.   +5 more
europepmc   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, Volume 33, Issue 5, Page 1845-1864, October 2026.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

MTR4: A Conserved Youth Factor for Vascular Endothelium

Aging Cell, Volume 25, Issue 10, October 2026.
Senescence‐induced SYVN1 degrades MTR4 via K638 ubiquitination. MTR4 loss disrupts its binding to BUB3 and destabilizes BUB3, diminishing BUBR1 and driving endothelial senescence. MTR4 restoration reverses vascular aging in mice and extends C. elegans lifespan.
Zhenyuan Guo, Zhiqiang Chen, Jiaqi Sun, Xiaojun Zhou, Chengzhi Ni, Yuxiang Zhang, Pengfei Qiang, Lu Zhang   +7 more
wiley   +1 more source