Results 181 to 190 of about 119,642 (302)

Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses

Nature Communications
RNA interference (RNAi) is a gene-silencing mechanism triggered by the cytosolic entry of double-stranded RNAs (dsRNAs). Many animal cells internalize extracellular dsRNAs via endocytosis for RNAi induction. However, it is not clear how the endocytosed dsRNAs are translocated into the cytosol across the endo/lysosomal membrane.
Tsubasa Tanaka, Tamaki Yano, Shingo Usuki, Yoko Seo, Kento Mizuta, Maho Okaguchi, Maki Yamaguchi, Kazuko Hanyu-Nakamura, Noriko Toyama-Sorimachi, Katja Brückner, Akira Nakamura   +10 more
openaire   +3 more sources

Neuronal loss of the pentose phosphate pathway in the living nervous system is causally linked to [NADPH] reduction and elevated oxidative stress

The Journal of Physiology, EarlyView.
Abstract figure legend Using genetically encoded sensors for NADPH and H2O2 in the living Drosophila nervous system, neuron‐specific PPP knockdown is shown to result in reduced neuronal NADPH levels and elevated neuronal H2O2 levels and oxidative stress.
Stephan Müller, Nina Surina, Andrés Köhler‐Solís, Ioannis Nellas, Astrid Fleige, Sebastian Görtz, Stefanie Schirmeier   +6 more
wiley   +1 more source

Potencial tehnologije SIGS za zatiranje glive Verticillium nonalfalfae

Hmeljarski Bilten
Gliva Verticillium nonalfalfae je talni patogen hmelja (Humulus lupulus L.), ki povzroča bolezen verticilijsko uvelost, ki lahko ob pojavu visoko virulentnih izolatov v hmeljiščih popolnoma uniči pridelek.
Taja Jeseničnik
doaj  

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1212-1224, June 2026.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

Mycovirus Vector‐Mediated RNAi for Effective Gene Knockdown in Pine Wood Nematodes

Plant Biotechnology Journal, EarlyView.
Ruiling Bian, Yifan Zhang, Zhihao Zhang, Yuchi Bai, Peiqin Li, Guanghui Tang, Lihua Guo, Huan Liu, Ida Bagus Andika, Qiaoxia Shang, Liying Sun   +10 more
wiley   +1 more source

Biological Pesticides as Viable Alternative to Synthetic Pesticides for Sustainable Agriculture and Nutrition: A Systematic Review

Journal of Sustainable Agriculture and Environment, Volume 5, Issue 2, June 2026.
ABSTRACT The overuse of synthetic pesticides in agriculture has raised significant environmental and health concerns. Biopesticides have emerged as viable, environmentally compatible alternatives. However, recent comprehensive reviews integrating all biopesticide categories and emphasizing their contribution to synthetic‐pesticide‐free and health‐safe ...
Molalign Assefa, Mohammed Tariq Saeed, Tahira Naz, Youpeng Fan, Xiangyu Zhao, Yuanda Song   +5 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Enhancing Stored Wheat Shelf Life: Advances in Storage Technologies, Integrated Pest Management, and Climate‐Responsive Approaches

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT Recent advances in agricultural production and storage systems have contributed to a significant enhancement in annual wheat production and preservation, aimed at satisfying increasing consumer demands. Despite such potential developments, there are still significant post‐harvest losses in stored wheat, induced by destructive pests, grain ...
Hafiz Muhammad Bilal Yousuf, Muhammad Yasin, Kurt A. Rosentrater, Muhammad Asif Khan   +3 more
wiley   +1 more source

Next‐Generation Sustainable Food Production Through Integrative Biotechnology, AI, and Climate‐Resilient Innovations

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT By 2050, the global population is projected to reach ~10 billion, leading to 50% increase in food demand. This growth will place immense pressure on agricultural systems that are already struggling with the impacts of climate change and resource depletion.
Chaquayla Katam, Hajra Maqsood, Brooke Bucci, Sixue Chen   +3 more
wiley   +1 more source