Results 181 to 190 of about 73,913 (251)

Cold-adapted RNA polymerase from <i>Pseudomonas</i> phage Njord improves synthesis of therapeutic mRNA. [PDF]

Proc Natl Acad Sci U S A
Nye DB, Chen TH, Curcuru JL, Wolf EJ, Molé CN, Kunte VA, Ryan M, Mitchell L, Schwarz DS, Whipple JM, Chan SH, Corrêa IR.   +11 more
europepmc   +1 more source

Live‐cell FRET imaging‐based efficacy prediction of EGFR‐TKIs in EGFR L858R‐mutant NSCLC

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
At the single‐cell level, live‐cell FRET microscopy was used to integrate the EGFRL858R‐GRB2 interaction with cellular phenotypic features to predict the efficacy of EGFR‐TKIs. The EGFRL858R‐GRB2 interaction‐based T‐score can evaluate the on‐target activity of EGFR‐TKIs against EGFRL858R.
Xin Li, Lingao Dai, Pingshan Yang, Shuanghe Li, Chuan Peng, Shiyao Li, Beini Sun, Songwang Cai, Xiaoping Wang, Tongsheng Chen   +9 more
wiley   +1 more source

Enhanced Delivery of Nucleic Acids to Insect Cells by Star Polycation Formulation. [PDF]

Insects
Shahmohammadi N, Song T, Khan F, Majidiani S, Kim Y.   +4 more
europepmc   +1 more source

Life‐History, Stress‐Resistance, and Transcriptomic Variation Among a Mexican Caenorhabditis elegans Isolate and Contemporary and Ancestral N2 Lineages

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared a recently isolated wild strain of Caenorhabditis elegans from Mexico City (VJV2) with the contemporary standard N2 Lab strain and the cryopreserved N2 Ancestral lineage. The strains differed in lifespan, fertility, and survival under pathogen, oxidative, and heat stress.
Jaqueline Hersch‐González, Nallely Cano‐Domínguez, Mariana Zurita‐León, Francisco Pinta‐Castro, Maribel Soto‐Nava, Santiago Avila‐Rios, Victor Julian Valdes   +6 more
wiley   +1 more source

Novel dsRNA designs increase the stability and bioefficacy of RNAi-based pesticides for <i>Varroa destructor</i>. [PDF]

Front Insect Sci
Muita BK, Damayo JE, Remnant EJ, Smith NA, Greaves IK, Ghodke AB, Kumaran N, Roberts JMK.   +7 more
europepmc   +1 more source

Domesticated bacterial origin genes regulate homeostasis of the insect gut microbiome and empower adaptation

iMeta, Volume 5, Issue 5, October 2026.
Horizontal gene transfer introduced bacterial CDC genes into the leafhopper genome, providing genetic material for subsequent evolutionary innovation. Different CDC copies diversified at the sequence, structural, and functional levels. RdCDC3 retained its ancestral pore‐forming activity and was recruited for egg defense, whereas RdCDC9 lost its ...
Zhenjia Zhang, Yubo Zhang, Kun Zhao, Guangyuan Cheng, Zhihao Lu, Dongju Wang, Yiqun Liu, Jianguo Wu, Liying Wang, Lisheng Zhang, Xinhai Ye, Li Yu, Wei Zhang, Yi Li   +13 more
wiley   +1 more source

SARS-CoV-2 defective viral genomes from distinct genomic regions drive divergent interferon responses. [PDF]

PLoS Pathog
Brennan JW, Spandau S, Xu J, Wang X, Aull H, Wang G, Connor S, Pryhuber GS, Mariani TJ, Serra-Moreno R, Weiss SR, Sun Y.   +11 more
europepmc   +1 more source

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Influenza A virus modulates host innate immune pathways, including TLR, RIG‐I, MAPK, and NF‐κB signaling, to support replication and drive inflammatory pathology. Plant‐derived phytocompounds target these interconnected pathways, offering a potential host‐directed immunomodulatory approach complementary to conventional antivirals.
Dibakar Chowdhury, Hillary A. Vanderven, Phurpa Wangchuk, Subir Sarker   +3 more
wiley   +1 more source

Mechanisms and Application of Bacteriophages in Regulating Intestinal Health of Livestock and Poultry

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Bacteriophages offer targeted, self‐limiting control of intestinal pathogens in livestock and poultry. This review integrates their biological properties, mechanisms of gut‐health promotion, key experimental evidence, application strategies, and current challenges, outlining a path toward sustainable animal production and global food security ...
Manman Song, Yuying Fan, Liguo Zhang, Wenhao Qi, Lin Li, Gang Zhao, Jianwei He   +6 more
wiley   +1 more source

Engineered <i>Escherichia coli</i>-Derived dsRNA Identifies β-Tubulin as a Candidate RNAi Target in Mosquito Larvae. [PDF]

Insects
Wang K, Bi Z, Zhao T, Pan Y, Wu J, Liu X, Xing D, Wu J, Li C.   +8 more
europepmc   +1 more source