Results 161 to 170 of about 119,642 (302)

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, EarlyView.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor

Journal of Biological Engineering
Background Infections with various RNA viruses and certain DNA viruses may produce double-stranded RNA (dsRNA) during replication, which trigger host innate immune responses.
Michihito Sasaki, Eri Fujii, Satoko Sasaki, Takuma Ariizumi, Kei Konishi, Akihiko Sato, William W. Hall, Hirofumi Sawa, Yasuko Orba   +8 more
doaj   +1 more source

Influenza A virus circumvents the innate immune response through the sequestration of double-stranded RNA

Journal of Virology
Double-stranded RNA (dsRNA), which induces an innate immune response against viral infections, is rarely detected in influenza A virus (IAV)-infected cells.
Masahiro Nakano, Sho Miyamoto, Chiho Ohnishi, Chiharu Nogami, Nanami Hirose, Yoko Fujita-Fujiharu, Yukiko Muramoto, Takeshi Noda   +7 more
doaj   +1 more source

Southern Corn Rootworm (Coleoptera: Chrysomelidae) Adult Emergence and Population Growth Assessment After Selection With Vacuolar ATPase-A double-stranded RNA Over Multiple Generations [PDF]

, 2019
The southern corn rootworm, Diabrotica undecimpunctata howardi Barber (Coleoptera: Chrysomelidae), was exposed over multiple generations to vacuolar (v)ATPase-A double-stranded (ds)RNA, first as adults and later, as neonate larvae. During adult selection,
Meinke, Lance J., Pereira, Adriano E, Siegfried, Blair D., Tenhumberg, Brigitte   +3 more
core   +1 more source

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, EarlyView.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

Assessing various administration strategies for dsRNA vaccine delivery: a concise review of VP15-WSSV research progress in tiger shrimp Penaeus monodon

Jurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract     Highlight Research 1. The dsRNA application should correspond to the developmental stages of shrimp 2. Immersion method was commonly used for larvae for handling many individuals 3.
Andi Parenrengi, Samuel Lante, Emma Suryati, Rosmiati Rosmiati, Sulaeman Sulaeman, Herlinah Herlinah, Yosie Andriani   +6 more
doaj   +1 more source

Host‐Induced Silencing of Rhizoctonia Solani 5‐Enolpyruvylshikimate‐3‐Phosphate Synthase Impairs Its Virulence in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sheath blight disease of rice caused by the fungal pathogen R. solani AG1‐IA remains a big threat to rice production worldwide. A limited genetic variation in rice for tolerance to this pathogen and little success in understanding how it defeats host defence are major reasons behind it.
Vinod Kumar, Apoorva Prasad, Akshita Goel, Vijay Kumar Sharma, Jagjeet Singh Lore, Arun Kumar   +5 more
wiley   +1 more source