Results 141 to 150 of about 68,502 (270)

Phenotypic effect of dsRNA injections in fifth instar larvae.

, 2014
(A) Size comparison of ampr, vvl and Met dsRNA-injected prepupae. (B) ampr dsRNA-injected prepupal eyes. (C) ampr dsRNA injected normal adult. (D) ampr dsRNA-injected pupa. (E) ampr dsRNA-injected pupal eyes.
Leila Chaieb (580293), CeCe Cheng (580291), Takashi Koyama (417981), Yuichiro Suzuki (137468), Wendy A. Smith (137465), Prioty Sarwar (580294), Amy Ko (580292), Christen K. Mirth (580295)   +7 more
core   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

The effect of dsRNA size on RNAi knockdown efficiency.

, 2012
(A) Location of EGFP dsRNAs relative to the EGFP gene. Green: the full-length EGFP gene (minus noncoding portion). Red: long dsRNA (520 bp). Purple: intermediate dsRNA (69 bp). Blue: short dsRNA (30/31 bp). (B) Uninjected pu11 Tribolium larvae.
Yoshinori Tomoyasu (48231), Keita Miyata (124456), Susan J. Brown (19392), Sherry C. Miller (124453)   +3 more
core   +1 more source

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

Cell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu, Bingyu Cai, Tingting Gao, Wumei Wei, Liu Wang, Qi Zhou, Wei Li, Jie Hao, Jun Wu   +8 more
wiley   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, EarlyView.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Double-stranded RNA antiviral signature in early multiple sclerosis

Frontiers in Microbiology
IntroductionViruses, particularly Epstein–Barr virus (EBV), are strongly implicated in multiple sclerosis (MS) pathogenesis, yet reliable biomarkers of active viral replication remain limited.
Vasileios Gouzouasis, Vasileios Gouzouasis, Ioannis Sarrigeorgiou, Margaritis Tsifintaris, Nikos Markoglou, Urania Georgopoulou, Peggy Lymberi, Maria Anagnostouli, Lesley Probert, Antonis Giannakakis, Antonis Giannakakis   +10 more
doaj   +1 more source

Electrophorosis of dsRNA-CarE.

, 2014
M: Molecular weight marker 5000; 1, 2, 3: dsRNA-CarE. Three groups of dsRNA-CarE were dissolved in 50 µL diethypyrocarbonate (DEPC)-treated water, analyzed with gel electrophoresis (1% agarose).
Xin-Rui Yu (619057), You-Hui Gong (619056), Xue-yan Shi (619059), Xi-Wu Gao (619060), Qing-Li Shang (619058)   +4 more
core   +1 more source