Results 141 to 150 of about 73,913 (251)

TcFur1, a furin 1 ortholog in Tribolium castaneum, regulates reproduction and carbohydrate metabolism without affecting lipid homeostasis

Insect Molecular Biology, EarlyView.
TcFur1, a furin 1 ortholog in Tribolium castaneum, is highly expressed in pupae and declines in adults. TcFur1 knockdown reduces oviposition but does not alter triacylglycerol levels or total lipase activity. TcFur1 knockdown increases circulating trehalose and decreases expression of insulin‐like peptides and the AKH receptor.
Julia Sanches‐Almeida, Lais Lindgren Porto, David Majerowicz   +2 more
wiley   +1 more source

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano   +8 more
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Engineered Yarrowia lipolytica inducing gene silencing confers control ability against gray mold in plants

Journal of Integrative Plant Biology, EarlyView.
Engineered the plant‐colonizing yeast Yarrowia lipolytica to produce and deliver double‐stranded RNAs targeting key genes of the gray mold fungus Botrytis cinerea produced a ‘living factory’ that continuously synthesizes and releases gene‐silencing molecules on plant surfaces, effectively suppressing the pathogen.
Mengjie Liu, Heng Shen, Jie Li, Mei Hao, Yelei Sun, Wenxing Liang   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha

New Phytologist, EarlyView.
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz, Eduardo Flores‐Sandoval, Ye Xu, Yu Yu, Ximena Gutiérrez‐Ramos, Cristian Y. González‐Rangel, Omar Oltehua‐López, Ana E. Dorantes‐Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Xuemei Chen, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga‐Vazquez   +17 more
wiley   +1 more source

Efficiency of RNAi‐based gene silencing in fungi: a meta‐analysis

New Phytologist, EarlyView.
Mechanistic interpretation of RNAi efficiency across fungal lifestyles and delivery strategies based on the present meta‐analysis. Summary RNA interference (RNAi) shows great potential to protect crops against fungal diseases, yet reported protection efficiencies vary greatly, and our understanding of the factors responsible for this variance remains ...
Patrick Barth, Jakob Drumm, Alexandra Erika Schmidt, Florian Hartig, Aline Koch   +4 more
wiley   +1 more source

Gender Control of Mouse Embryos by Activation of TLR7/8 on X Sperm via Ligands dsRNA-40 and dsRNA-DR

Gender control technologies are promising for enhancing the production efficiency of the farm animal industry, and preventing sex-linked hereditary diseases in humans.
Linjun Hong, Zicong Li, Yunfei Hou, Jingfeng Peng, Enqin Zheng, Zhenfang Wu   +5 more
core   +1 more source

Metabolic convergence on TOR signaling in the chestnut blight fungus and its regulation by host plant signals

New Phytologist, EarlyView.
Proposed model of metabolic convergence on the target of rapamycin (TOR) pathway in Cryphonectria parasitica. Twelve core genes involved in diverse metabolic pathways act as upstream regulators or downstream effectors of TOR kinase. Dysregulation of these genes mimics an inhibited TOR state, leading to restricted hyphal growth and enhanced trehalose ...
Yo‐Han Ko, Jeesun Chun, Geonmin Kim, Jiwon Yu, Dae‐Hyuk Kim   +4 more
wiley   +1 more source