Results 121 to 130 of about 56,868 (220)

The Fate of dsRNA in the Nucleus [PDF]

Cell, 2001
Zhang, Zuo, Carmichael, Gordon G.
openaire   +1 more source

HvarAKR1B1‐mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation

Pest Management Science, Volume 82, Issue 8, Page 7903-7914, August 2026.
Starvation stress significantly affected the growth and development of Hippodamia variegata. Combined transcriptome and metabolome analysis and RNA interference verification revealed that HvarAKR1B1 may be involved in the response of Hippodamia variegata to starvation stress.
Bing‐mei Song, De‐qin Hu, Yuan Li, Wang‐quan Jiao, Xiao‐li Ma, Hong‐sheng Pan   +5 more
wiley   +1 more source

Unveiling the AcSirt2‐FOXO‐Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana

Aging Cell, Volume 25, Issue 8, August 2026.
Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma, Zhengang Ma, Tingyue Huang, Qianmin Hai, Xiaoqun Dang, Jinshan Xu, Jialing Bao, Zachary Y. Huang, Zeyang Zhou   +8 more
wiley   +1 more source

Viral Transmission Between Heterobasidion parviporum Strains in Wood Billets and Decaying Stumps

Forest Pathology, Volume 56, Issue 4, August 2026.
ABSTRACT The combined use of Heterobasidion partitiviruses HetPV13‐an1 and HetPV15‐pa1 is considered a promising biocontrol approach against Heterobasidion root and butt rot. Both viruses mediate debilitating effects in many Heterobasidion isolates and are transmitted efficiently in laboratory conditions.
Muhammad Kashif, Eeva J. Vainio, Tuula Piri, Jarkko Hantula   +3 more
wiley   +1 more source

Phyllosphere microbiome responses to spray-induced gene silencing targeting Phytophthora infestans in potato. [PDF]

NPJ Biofilms Microbiomes
Ghosh S, Sundararajan P, Gelena Kelbessa B, Ghadamgahi F, Whisson SC, Dubey M, Chawade A, Vetukuri RR.   +7 more
europepmc   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, Volume 35, Issue 4, Page 364-375, August 2026.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

Norroa™ as a dsRNA biopesticide for <i>Varroa destructor</i>: insights from New Zealand research on mode of action, field efficacy, non-target effects, and social acceptance. [PDF]

Front Insect Sci
Lester PJ, Bulgarella M, Manley B, Masucci JD, McGruddy RA, Merk J, Narva K, Palmer S, Mercier OR, Smeele ZE.   +9 more
europepmc   +1 more source

Working So Hard: Double‐Stranded RNAs That Can Perform Both Gene Activation and Gene Silencing

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Working so hard: STING saRNAs are capable of not only entering the nucleus to induce subsequent target gene upregulation, but can also act as an siRNA to perform gene silencing. Chemical modifications in saRNA guide and passenger strands affect the strength of gene activation or gene silencing activity.
Virginia Wing‐Nam Chiu, Matthew Lawrence Hammill, Marwah Elabed, Sierra Varley, Yulia Lomonosova, Joseph Hoare, Jon Voutila, Henrik Hansen, Troels Koch, Jean‐Paul Desaulniers   +9 more
wiley   +1 more source

The SQSTM1/<i>p62</i> of Pacific White Shrimp (<i>Litopenaeus vannamei</i>) Is Involved in the Oxidative Stress Induced by Ammonia Exposure. [PDF]

Animals (Basel)
Lu W, Luo J, Feng L, Cai S, Jian J, Yang S.   +5 more
europepmc   +1 more source

How Do DICER1 Syndrome Mutations Disrupt Catalysis? Unveiling Dicer Metal Binding Architecture and Mechanism of Action Using MD Simulations and QM/MM Calculations

Journal of Computational Chemistry, Volume 47, Issue 18, July 5, 2026.
Dicer plays a vital role in gene regulation, making understanding its function critical for drug design and addressing human diseases. This article uses a combination of MD and QM/MM techniques to elucidate structural details of the Dicer–substrate complex, the Dicer catalytic mechanism, and the misfunction of DICER1‐syndrome‐causing mutants.
Dylan J. Nikkel, Stacey D. Wetmore
wiley   +1 more source