Results 121 to 130 of about 68,502 (270)

Effect of dsRNA dose on feeding RNAi efficiency.

, 2014
(A) wild-type, (B) KA dsRNA, (C–F) lac2 RNAi with various doses of dsRNA, (G–J) ebony RNAi with various doses of dsRNA. Note that feeding 500 ng/mL or more of dsRNA induced clear pigmentation defects both in lac2 and ebony RNAi.
Yoshinori Tomoyasu (48231), Yuanji Zhang (9913), Keita Miyata (124456), Parthasarathy Ramaseshadri (101924), Gerrit Segers (101926), Renata Bolognesi (101933)   +5 more
core   +1 more source

Heterogeneity of dsRNA-induced apoptosis [PDF]

, 2020
Double-stranded RNA is now being identified as one of the most significant activators of antiviral responses. Once cytoplasmic sensors detect dsRNA, a series of antiviral responses will be initiated, including inhibition of protein synthesis ...
Ren, Xiaoyan
core  

RNA‐DNA Fusomer Fibers With Customizable Physicochemical, Mechanical, and Biological Properties for Next‐Generation Therapeutics

Small, EarlyView.
ABSTRACT We introduce RNA‐DNA fusomers, a new class of chemically synthesized oligonucleotides that combine the versatile properties of RNA and DNA within a single sequence and self‐assemble into higher‐order functional structures via a simple one‐pot annealing reaction.
Yasmine Radwan, Laura P. Rebolledo, Yelixza I. Avila, Elizabeth Skelly, Lauren Rackley, Julio Navas Hernandez, Renata de Freitas Saito, Laxmi K. Pandey, Hemani Chhabra, Alexander J. Lushnikov, Tatiane Katsue Furuya, Ana Luiza Lomba, Da Shi, Edward Cedrone, Ian Marriott, Morgan R. Chandler, Meni Wanunu, Aleksei Aksimentiev, Alexey V. Krasnoslobodtsev, Roger Chammas, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Research progress on immune mechanism and control strategy of dsRNA impurities in mRNA vaccine

Expert Review of Vaccines
Introduction Double-stranded RNA (dsRNA) is a key impurity of mRNA vaccines prepared by in vitro transcription (IVT) and is primarily transcribed by T7 RNA polymerase.
Xinjun Liu, Chaoying Hu, Qian He, Yu Bai, Xuanxuan Zhang, Zhihao Fu, Xiao Ma, Miao Xu, Zhenglun Liang, Qunying Mao   +9 more
doaj   +1 more source

Diagram of dsRNA injection analysis.

Experimental design for dsRNA injection analysis. Male last instar nymphs (N6 stage) were obtained from a mature colony, and dsRNA injection was performed in each individual.
Satoshi Miyazaki (19187), Kokuto Fujiwara (12962399), Kiyoto Maekawa (464704)   +2 more
core   +1 more source

Oral delivery of dsRNA lipoplexes to German cockroach protects dsRNA from degradation and induces RNAi response

, 2017
[Background] In the past years, the concept of RNAi application for insect pest control has been proposed, considering the disruption of vital genes. However, the efficiency of RNAi is variable between different insect groups, especially by oral delivery
Huang. J. H., How‐Jing Lee, Yun Liu, Lin, Yu-Hsien, Jia‐Hsin Huang, Xavier Belles, Yu‐Hsien Lin, Liu, Yun, Bellés, Xavier, Lee, How-Jing   +9 more
core   +1 more source

Challenging the prokaryotic MGE‐defense origin of eukaryotic RNA editing

mLife, EarlyView.
Yuange Duan, Qiuhua Xie, Jiajia Yang, Wanzhi Cai, Hu Li   +4 more
wiley   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

Insect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji, Qing Xie, Xiaoxiao Chang, Juan Shi   +3 more
wiley   +1 more source

awilcox83/dsRNA-sequencing: First release

, 2018
<p>No description provided. </p ...
Alexander H. Wilcox, Samuel L. Díaz Muñoz   +1 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source