Results 101 to 110 of about 119,642 (302)
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]
, 2013 Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M +4 more
core +1 more source
Advanced Science, EarlyView.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source
Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I
Scientific Reports, 2023 Retinoic acid-inducible gene I (RIG-I) is the most front-line cytoplasmic viral RNA sensor and induces antiviral immune responses. RIG-I recognizes short double-stranded (dsRNA) ( 500 bp) to trigger antiviral signaling.
Jung Hyun Im +6 more
doaj +1 more source
Scientific Reports, 2019 Mosquito-borne diseases are a major threat to human health and are responsible for millions of deaths globally each year. Vector control is one of the most important approaches used in reducing the incidence of these diseases.
Ramesh Kumar Dhandapani +3 more
semanticscholar +1 more source
Quelling an innate response to dsRNA
Oncotarget, 2015 The interferon inducible oligoadenylate synthetase (OAS)/RNase L pathway is an innate defense against invading viral pathogens that is linked to cell survival [reviewed in 1]. OAS family proteins are pattern recognition receptors that recognize double-stranded RNA (dsRNA), a pathogen-associated molecular pattern.
Kristen M, Ogden, B V Venkataram, Prasad
openaire +2 more sources
Animal Research and One Health, EarlyView.Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li +18 more
wiley +1 more source
Real‐Time Monitoring of In Vitro Transcription for Production of mRNA Using Raman Spectroscopy
Biotechnology and Bioengineering, EarlyView.Schematic depicting the workflow for model building and validation using Raman spectroscopy for real‐time monitoring of IVT. ABSTRACT The success of COVID‐19 mRNA vaccines showcased the transformative potential of this adaptable, plug‐and‐play, and rapid response platform.
Julia Puppin Chaves Fulber +4 more
wiley +1 more source
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Science, 2015 RNA editing helps identify cellular RNAs Adenosine bases in messenger RNA (mRNAs) can be enzymatically modified and changed into inosine bases. This RNA “editing” is mediated by adenosine deaminase acting on RNA (ADAR) enzymes. Liddicoat et al. show that
Brian J. Liddicoat +8 more
semanticscholar +1 more source
The use of mycoviruses in the control of forest diseases [PDF]
, 2016 Producción CientíficaFifteen families of mycoviruses have been described and 80% of these catalogued. However, their evolutionary relationship with fungi is not clear.
Díez Casero, Julio Javier +2 more
core +1 more source