Results 131 to 140 of about 73,913 (251)

Figure S5. Degradation of naked and liposome-encapsulated dsRNA in gut contents from Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies

, 2019
Degradation of naked dsRNA and dsRNA combined with a liposome agent in (mixed sex) adult gut contents measured by band fluorescence intensity following 1.5% gel electrophoresis.
Jae Yeon Park (6615821), Alison Tayler (7869878), Daniel Heschuk (7869881), Steve Whyard (7869887), David Giesbrecht (7869884)   +4 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

dsRNA stability in solutions and in plant leaves.

, 2017
Stability of cathepsin D, chitin synthase, inhibitor of apoptosis and GFP dsRNAs from solutions in which M. paniculata leaflets were soaked (A) and in leaves (B) on the 11th day of the feeding assay were analysed by agarose gel electrophoresis.
Bryce W. Falk (195946), Diogo Manzano Galdeano (3829696), Michèle Claire Breton (3829693), João Roberto Spotti Lopes (3829699), Marcos Antonio Machado (3829690)   +4 more
core   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Double-stranded RNA antiviral signature in early multiple sclerosis

Frontiers in Microbiology
IntroductionViruses, particularly Epstein–Barr virus (EBV), are strongly implicated in multiple sclerosis (MS) pathogenesis, yet reliable biomarkers of active viral replication remain limited.
Vasileios Gouzouasis, Vasileios Gouzouasis, Ioannis Sarrigeorgiou, Margaritis Tsifintaris, Nikos Markoglou, Urania Georgopoulou, Peggy Lymberi, Maria Anagnostouli, Lesley Probert, Antonis Giannakakis, Antonis Giannakakis   +10 more
doaj   +1 more source

Gene expression is reduced in trans by inosine-containing dsRNA

, 2008
Inosine residues may be introduced into long dsRNA (double-stranded RNA) molecules by the action of a family of editing enzymes, ADARs (adenosine deaminases that act on RNA).
A D J Scadden
core  

Detection of RV dsRNA in infected cells by immunofluorescence.

, 2015
RV infected and mock-infected HUVECs (A) or Vero cells (B) were fixed with methanol and examined for presence of dsRNA by indirect immunofluorescence using dsRNA-specific antibody. Nuclei were counterstained with DAPI.
Joseph Icenogle (441987), Ludmila Perelygina (441985), Adebola Adebayo (770521), Maureen Metcalfe (441986)   +3 more
core   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

RNA activation in insects: From emerging evidence to molecular applications

Insect Molecular Biology, EarlyView.
Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley   +1 more source