Results 61 to 70 of about 70,834 (199)

Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells

Frontiers in Cellular and Infection Microbiology, 2018
An important step in the initiation of the innate immune response to virus infection is the recognition of non-self, viral RNA, including double-stranded RNA (dsRNA), by cytoplasmic pattern recognition receptors (PRRs).
Elizabeth J. Mateer, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source

SIGS vs HIGS: a study on the efficacy of two dsRNA delivery strategies to silence Fusarium FgCYP51 genes in infected host and non‐host plants

Molecular plant pathology, 2019
Summary CYP3RNA, a double‐stranded (ds)RNA designed to concomitantly target the two sterol 14α‐demethylase genes FgCYP51A and FgCYP51B and the fungal virulence factor FgCYP51C, inhibits the growth of the ascomycete fungus Fusarium graminearum (Fg) in ...
A. Koch, L. Höfle, B. Werner, J. Imani, A. Schmidt, L. Jelonek, K. Kogel   +6 more
semanticscholar   +1 more source

Analysis of Double-Stranded RNA from Microbial Communities Identifies Double-Stranded RNA Virus-like Elements

Cell Reports, 2014
Double-stranded RNA (dsRNA) can function as genetic information and may have served as genomic material before the existence of DNA-based life. By developing a method to purify dsRNA, we have investigated the diversity of dsRNA in microbial populations ...
Carolyn J. Decker, Roy Parker
doaj   +1 more source

Cellular origins of dsRNA, their recognition and consequences

Nature reviews. Molecular cell biology, 2021
Y. G. Chen, S. Hur
semanticscholar   +1 more source

Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer

Drug Delivery, 2017
Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge
Chen-Lin Feng, Yan-Xing Han, Hui-Hui Guo, Xiao-Lei Ma, Zhi-Qiang Wang, Lu-Lu Wang, Wen-Sheng Zheng, Jian-Dong Jiang   +7 more
doaj   +1 more source

Reporters transiently transfected into mammalian cells are highly sensitive to translational repression induced by dsRNA expression.

PLoS ONE, 2014
In mammals, double-stranded RNA (dsRNA) can mediate sequence-specific RNA interference, activate sequence-independent interferon response, or undergo RNA editing by adenosine deaminases. We showed that long hairpin dsRNA expression had negligible effects
Jana Nejepinska, Radek Malik, Susan Wagner, Petr Svoboda   +3 more
doaj   +1 more source

Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects

RNA Biology, 2016
RNA interference (RNAi) has become a widely used reverse genetic tool to study gene function in eukaryotic organisms and is being developed as a technology for insect pest management. The efficiency of RNAi varies among organisms.
J. Shukla, Megha Kalsi, Amit Sethi, K. Narva, E. Fishilevich, Satnam Singh, Kanakachari Mogilicherla, S. R. Palli   +7 more
semanticscholar   +1 more source

Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells

BMC Immunology, 2011
Background Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms.
Tsao Ming-Sound, Yun James J, Der Sandy D   +2 more
doaj   +1 more source

Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects

Viruses, 2019
Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). Specifically, virally derived dsRNA is recognized and cleaved by the enzyme Dicer2 into short interfering RNAs ...
D. Santos, Lina Mingels, Elise Vogel, Luoluo Wang, O. Christiaens, K. Cappelle, N. Wynant, Y. Gansemans, F. van Nieuwerburgh, G. Smagghe, L. Swevers, J. Vanden Broeck   +11 more
semanticscholar   +1 more source

Development of Biolayer Interferometry (BLI)-Based Double-Stranded RNA Detection Method with Application in mRNA-Based Therapeutics and Vaccines

Pharmaceutics
Background: In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially causing
Dharia Sara Silas, Bindiya Juneja, Keerat Kaur, Muralikrishna Narayanareddy Gari, Yingjian You, Youmi Moon, Yizhuo Chen, Srishti Arora, Johanna Hansen, Kathir Muthusamy, Yue Fu, Nisha Palackal, Erica A. Pyles   +12 more
doaj   +1 more source