Results 71 to 80 of about 68,502 (270)

Detection of dsRNA in Grapevines Showing Symptoms of Rupestris Stem Pitting Disease and the Variabilities Encountered

, 1991
Rupestris stem pitting (rSP), a graft-transmissible grapevine disease, can be identified only by its reaction (pitted wood) on inoculated Vitis rupestris ‘St.
Azzam, Ossmat I., Golino, Deborah, Gonsalves, Dennis   +2 more
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

A dsRNA virus with filamentous viral particles [PDF]

Nature Communications, 2017
AbstractViruses with double-stranded RNA genomes form isometric particles or are capsidless. Here we report a double-stranded RNA virus, Colletotrichum camelliae filamentous virus 1 (CcFV-1) isolated from a fungal pathogen, that forms filamentous particles. CcFV-1 has eight genomic double-stranded RNAs, ranging from 990 to 2444 bp, encoding 10 putative
Hengxia Jia, Kaili Dong, Lingling Zhou, Guoping Wang, Ni Hong, Daohong Jiang, Wenxing Xu   +6 more
openaire   +3 more sources

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

International audienceThe small interfering RNA pathway is the primary antiviral defense mechanism in invertebrates and plants. This systemic mechanism relies on the recognition, transport, and internalization of double-stranded RNA (dsRNA).
Vinh, Joelle, Mukherjee, Shaeri, Fletcher, Sabrina, Blanc, Hervé, Verdier, Yann, Saleh, Maria-Carla, P, Bardossy, Eugenia, Moss, Thomas, Tomé-Poderti, Lorena, Frangeul, Lionel, Mongelli, Vanesa   +10 more
core   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

DsRNA-mediated knockdown of cactus results in increased Toll signaling.

(a-h) The expression of cactus (a, e) and the antimicrobial peptides defensin-2 (b, f), defensin-3 (c, g) and cecropin-2 (d, h) were assayed via RT-qPCR in whole adult beetles treated with 250 ng of cactus or malE dsRNA and then septically challenged ...
Ann T. Tate (3314862), Arun Prakash (3256941), Justin T. Critchlow (6916241), Katherine Y. Zhong (18056649)   +3 more
core   +1 more source

Duck Orbivirus and Egg Production: A Newly Identified Duck Orbivirus Is the Etiological Agent of Egg Production Decline in Chinese Breeder Ducks

Animal Research and One Health, EarlyView.
Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li, Jianhua Wang, Xuezhi Cui, Xinxing Chu, You Wang, Dongmin Hao, Mingqing Xu, Haixia Chang, Huihui Li, Mingtian Mao, Mian Wu, Chengguang Lu, Jing Tang, Suyun Liang, Zhanbao Guo, Zhengkui Zhou, Youxiang Diao, Shuisheng Hou, Yi Tang   +18 more
wiley   +1 more source

Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10

Frontiers in Immunology, 2018
Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of ...
Suki Man-Yan Lee, Tsz-Fung Yip, Sheng Yan, Dong-Yan Jin, Hong-Li Wei, Rey-Ting Guo, Joseph Sriyal Malik Peiris   +6 more
doaj   +1 more source

Study on a novel dsRNA virus isolated from the white root rot fungus, Rosellinia necatrix Prillieux, W89

, 2010
由白紋羽病菌 (Rosellinia necatrix Prillieux) 所引起之白紋羽病，為常見之植物根腐病害。此病原菌 (無性世代為Dematophora necatrix Prilleux）在分類上屬子囊菌炭角菌科，Rosellinia屬。其寄主範圍廣泛，台灣地區之發病記錄有七種，包括枇杷、梨樹、桃樹、蘋果、櫻花、葡萄、茶樹等。病株受感染後由根部開始枯死進而全株凋萎，以往使用土壤灌注方法施予藥劑雖可達到一定的防治效果，但長期使用化學藥劑除成本高昂外，更對環境造成沉重負擔 ...
Lin, Yu-Hsin, 林諭昕
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