Results 151 to 160 of about 1,165,839 (240)

Key role of TLR3 in type I IFN expression and apoptosis induction in IBDV-infected chicken fibroblast cells

Frontiers in Cellular and Infection Microbiology
Infectious Bursal Disease Virus (IBDV) (Avibirnavirus genus, Birnaviridae family) is a non-enveloped virus with a double-stranded RNA (dsRNA) genome.
Elisabet Diaz-Beneitez, Leyre Concostrina-Martínez, Liliana L. Cubas-Gaona, Altea Martín-Martínez, Juan R. Rodríguez, José F. Rodríguez, Fernando Almazán, Dolores Rodríguez   +7 more
doaj   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Mitochondria in Viral Infections: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
Viral infections remodel mitochondrial function through direct viral regulation and infection‐induced changes in host cellular processes. These alterations affect OXPHOS, mitochondrial metabolism, calcium homeostasis, membrane potential, redox regulation, dynamics, and apoptosis, with distinct effects on viral replication and host antiviral responses ...
Ha Young Oh, Hye Jin Shin
wiley   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, Volume 82, Issue 11, Page 10604-10614, November 2026.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Microbial Characteristics of Weissella cibaria HRL3 and Its Immunostimulatory Effects via TLR3/TLR9‐Dependent IFN‐α Production

Journal of Food Science, Volume 91, Issue 11, November 2026.
ABSTRACT Rhinacanthus nasutus (L.) Kurz is a medicinal plant whose roots, stems, and leaves are commonly used in tea and traditional Chinese medicine; however, the beneficial effects of its flowers remain to be investigated. In this study, the lactic acid bacteria (LAB) found in the flowers of R.
Fumie Niitsuma, Hiroka Sasahara, Akihiro Masaki, Ayaha Toritani, Minako Tsukamoto, Tomoya Takahashi, Sachi Tanaka   +6 more
wiley   +1 more source

Live Fast, Die Old: Lowering Insulin Signalling During Development Can Speed Growth, Increase Reproduction and Lifespan, but Impair Environmental Sensing and Harm Offspring in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 11, November 2026.
Developmental reduction of insulin/IGF‐1 signalling via daf‐2 RNAi accelerates development, increases early reproduction, fitness, and lifespan in C. elegans, but compromises environmental sensing. Reduced IIS promotes inappropriate offspring dauer entry and delays recovery from developmental arrest.
Sara D. Irish, Annabel Kimberley, Peter Lenart, Hanne Carlsson, Anna Braybrooke, Benjamin Towbin, Simone Immler, Alexei A. Maklakov   +7 more
wiley   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Mitochondrial Dysfunction as a Context‐Dependent Driver and Amplifier of the SASP: Targeting the mtDNA–cGAS–STING Axis for Next‐Generation Senotherapeutics

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Cellular senescence combines stable cell‐cycle arrest with mitochondrial and innate immune remodelling that shapes the senescence‐associated secretory phenotype (SASP). This narrative review evaluates mitochondrial dysfunction as a context‐dependent initiator or amplifier of senescence and examines mitochondrial DNA (mtDNA) sensing through ...
Hamza Kamaran Hama, Mohammed Ali Hama, Musa M. Zorab, Amirreza Gholami, Ammar Mohammed Al‐Farga   +4 more
wiley   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

Advanced Science
Tomato viral diseases severely restrict the safe and efficient tomato production, and current control methods are lacking. Therefore, the development of green and efficacious biopesticides is imperative.
Xuedong Liu, Xiaofei Liang, Zipeng Cai, Zheng Liu, Xuefeng Wang, Changyong Zhou, Mengji Cao, Sijia Liu   +7 more
doaj   +1 more source

Drosophila X virus-like particles as efficient dsRNA carriers for improved RNAi against the invasive species, Drosophila suzukii

RNA interference (RNAi) has been exploited as a promising strategy for pest control and also has great potential against the spotted wing drosophila (SWD) Drosophila suzukii. However, since RNAi is poorly induced in D.
Samakovli, Despina, Swevers, Luc, Xue, Qi, Taning, Nji Tizi Clauvis   +3 more
core   +1 more source