Results 141 to 150 of about 1,165,839 (240)

Metabolic convergence on TOR signaling in the chestnut blight fungus and its regulation by host plant signals

New Phytologist, EarlyView.
Proposed model of metabolic convergence on the target of rapamycin (TOR) pathway in Cryphonectria parasitica. Twelve core genes involved in diverse metabolic pathways act as upstream regulators or downstream effectors of TOR kinase. Dysregulation of these genes mimics an inhibited TOR state, leading to restricted hyphal growth and enhanced trehalose ...
Yo‐Han Ko, Jeesun Chun, Geonmin Kim, Jiwon Yu, Dae‐Hyuk Kim   +4 more
wiley   +1 more source

mRNA Decay Mediates Evolution and Biological Functions in Plant Gene Expression

Plant Biotechnology Journal, EarlyView.
ABSTRACT mRNA decay is a key post‐transcriptional regulatory mechanism that fine‐tunes plant development and stress adaptation through dynamic mRNA stability control, bridging fundamental biology and crop improvement. Current knowledge of mRNA decay mechanisms in plants, largely derived from Arabidopsis, is poorly generalisable across plant lineages ...
Haidan Wu, Dayin Lv, Yelin Huang, Yuchi He   +3 more
wiley   +1 more source

Presence of double-stranded RNAs in human and calf isolates of Cryptosporidium parvum [PDF]

, 2000
We examined the occurrence of 2 virus-like double-stranded (ds)RNAs in human and calf isolates of Cryptosporidium parvum senso latu and other microorganisms, including 7 other members of the genus. A total of 32 isolates of C.
Dykstra, C.C., Morgan, U.M., Khramtsovk, N.V., Griffiths, J.K., Upton, S.J., Chung, P.A., Arrowood, M.J.   +6 more
core  

The core of bluetongue virus binds double-stranded RNA.

, 2016
Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA.

core   +1 more source

Knockdown of mitotically associated long non‐coding RNA dysregulates endothelial functions, transcriptome and proteome

The Journal of Physiology, EarlyView.
Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley   +1 more source

Identification, Molecular Characterization, and Biology of a Novel Quadrivirus Infecting the Plant Fungus Allocryptovalsa sichuanensis

Viruses
A novel double-stranded RNA (dsRNA) virus was isolated and described from strain ZZZ210557 of plant endophyte Allocryptovalsa sichuanensis. The dsRNA virus contains four dsRNA segments, dsRNA1 to dsRNA4, with a size range of 3.8 to 5.1 kbp.
Yuxu Xie, Xianhong Wang, Xiuyuan Sun, Fanxing Ren, Meng Zhang, Chao Xu, Qingzhou Ma, Yuehua Geng, Rui Zang, Yashuang Guo   +9 more
doaj   +1 more source

Nontumor‐Specific mRNA Sensitization of Cold Tumors to Immune Checkpoint Blockade: Evidence, Bias, and Requirements for Translation

Advanced Oncology, Volume 1, Issue 1, December 2026.
Messenger RNA constructs encoding nontumor antigens are proposed to sensitize cold tumors to checkpoint blockade. Observational survival estimates favor vaccination but are heterogeneous, and bias‐focused analyses find no significant difference once time‐zero is aligned. Epitope spreading remains undemonstrated in humans. This review separates what the
Sarfaraz K. Niazi
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, Volume 20, Issue 11, Page 2584-2610, November 2026.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2821-2855, November 2026.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

Multiple Lipid Scramblases Regulate the Quantity of Extracellular Vesicle Production From the Plasma Membrane

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
Cells are wrapped in a double‐sided plasma membrane made up of fatty lipids that can release lipid‐wrapped fragments called extracellular vesicles (EVs). Diverse scramblase proteins, which shuffle lipids across cellular membranes in both directions, can promote EV release.
Bianca L. Guerra, Tanner Chase White, Alissa Rumin, Lauren Pitts, Alexander Nguyen, Vanshika Chauhan, Dinah Loerke, Ann M. Wehman   +7 more
wiley   +1 more source