Results 71 to 80 of about 1,362 (166)

The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson’s disease

npj Parkinson's Disease
Growing evidence suggests that the glymphatic system, driven by aquaporin-4 (AQP4) water channels, plays a key role in Parkinson’s disease (PD). We examined the impact of specific AQP4 variants on glymphatic function using diffusion tensor imaging along ...
Jianmei Qin, Yi Fang, Xiaojie Duanmu, Jiaqi Wen, Haoting Wu, Chenqing Wu, Tao Guo, Cheng Zhou, Qianshi Zheng, Weijin Yuan, Zihao Zhu, Jingwen Chen, Jingjing Wu, Mengze Jiang, Baorong Zhang, Xiaojun Xu, Xiaojun Guan, Minming Zhang   +17 more
doaj   +1 more source

Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery

Brain Informatics
Background Ischemic stroke may impair glymphatic clearance, but whether this is associated with post-stroke brain functional reorganization in humans remains unclear.
Yueyan Bian, Jiajia Zhang, Yifei Zhang, Hongxia Zhang, Xuejia Jia, Hongkai Wang, Xiuqin Jia, Qi Yang   +7 more
doaj   +1 more source

Noninvasive assessment of glymphatic dysfunction and IDH mutation in glioma with DTI-ALPS and DTI metrics

Quantitative Imaging in Medicine and Surgery
The occurrence and development of glioma are closely related to neuro-immunity. The glymphatic system (GS), a brain waste-clearance pathway, plays a critical role in neuro-immunity. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a non-invasive method to assess glymphatic dysfunction. This study had the following aims: (I) to
Fang, Kewei, Wang, Chenlong, Zhang, Yi, Wu, Shuang, Liu, Lu, Wen, Xiaoling   +5 more
openaire   +2 more sources

Similar DTI-ALPS metrics in Parkinson’s disease and essential tremor: a cross-sectional comparative analysis

Neuroradiology
Abstract Purpose This study investigated glymphatic function in tremor disorders using the diffusion tensor imaging–derived ALPS (analysis-along-the-perivascular-space) index, a non-invasive surrogate of perivascular fluid movement ...
Bruno, F, Innocenzi, A, Badini, P, Cella, M, Santobuono, C, Pertici, L, Catalucci, A, Saporito, G, Sucapane, P, Palumbo, P, Arrigoni, F, Barile, A, Di Cesare, E, Pistoia, F, Splendiani, A   +14 more
openaire   +4 more sources

How tobacco use disorder affects gray matter aberrance: The mediating effect of glymphatic system function

Brain Research Bulletin
Background: The glymphatic system (GS) represents a newly identified biological pathway, but its possible involvement in the pathophysiology of tobacco use disorder (TUD) remains unclear.
Mengzhe Zhang, Bohui Mei, Longyao Ma, Kaixin Li, Mengzhu Wang, Weijian Wang, Yong Zhang   +6 more
doaj   +1 more source

Evaluating the robustness of DTI-ALPS in clinical context: a meta-analytic parallel on Alzheimer’s and Parkinson’s diseases

Scientific Reports
In recent years, the glymphatic system has received increasing attention due to its possible implications in biological mechanisms associated with neurodegeneration. In the field of human brain mapping, this led to the development of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. While this index has been repeatedly used
Tommaso Costa, Jordi Manuello, Enrico Premi, Irene Mattioli, Luca Lasagna, Clara Ballonga Lahoz, Franco Cauda, Sergio Duca, Donato Liloia   +8 more
openaire   +3 more sources

Application of diffusion tensor imaging analysis along perivascular spaces in evaluating glymphatic system function in type 2 diabetes mellitus

Frontiers in Neuroscience
BackgroundType 2 diabetes mellitus (T2DM) is often accompanied by cognitive dysfunction, though its underlying mechanisms remain unclear. Impaired glymphatic system function may contribute to cognitive impairment.
Yujuan Wang, Yujuan Wang, Yang Ji, Yang Ji, Guangxu Han, Ya Li, Ya Li, Jin Yan, Jin Yan, Yuanyuan Huo, Yuanyuan Huo, Xiaoqing Liu, Xiaoqing Liu, Shuanghong Zhang, Shuanghong Zhang   +14 more
doaj   +1 more source

Clinical and brain volumetric correlates of decreased DTI-ALPS, suggestive of local glymphatic dysfunction, in iRBD

npj Parkinson's Disease
Glymphatic alterations may underlie neurodegeneration in alpha-synucleinopathies. Reduced Diffusion-Tensor Imaging ALong the Perivascular Space (DTI-ALPS), a proxy of perivascular glymphatic activity, has been scarcely studied in isolated REM sleep ...
Ignacio Roura, Jèssica Pardo, Cristina Martín-Barceló, Carles Falcon, Javier Oltra, Anna Campabadal, Nuria Bargalló, Mònica Serradell, Gerard Mayà, Angelica Montini, Claustre Pont-Sunyer, Carles Gaig, Mariateresa Buongiorno, Carme Junqué, Alex Iranzo, Bàrbara Segura   +15 more
doaj   +1 more source

Glymphatic clearance as revealed by diffusion tensor imaging along the perivascular space (DTI‐ALPS) is associated with Alzheimer's disease neuropathology and periodic rsEEG alpha rhythms in mild cognitive impairment participants

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We evaluated whether the brain glymphatic drainage function estimated by the diffusion tensor imaging along the perivascular space (DTI‐ALPS) index relates to white matter (WM) integrity, Alzheimer's disease (AD) neuropathology, resting ...
Susanna Lopez, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Matteo Carpi, Dario Arnaldi, Francesco Famà, Matteo Pardini, Federico Massa, Franco Marinozzi, Fabiano Bini, Giorgia Treves, Andrea Soricelli, Marco Salvatore, Franco Giubilei, Laura Ziccardi, Bahar Güntekin, Görsev Yener, Raffaele Ferri, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Francesco Infarinato, Paola Romano, Moira Marizzoni, Giovanni B. Frisoni, Paolo Barone, Arianna Cappiello, Sofia Cuoco, Laura Bonanni, Anita D'Anselmo, Angelo Antonini, Eleonora Fiorenzato, Simone Cauzzo, Roberta Biundo, Fabrizia D'Antonio, Maria Francesca De Pandis, Simone Marziali, Giuseppe Bruno, Filippo Carducci, Claudio Babiloni   +41 more
doaj   +1 more source

DTI-ALPS alterations in cerebral small vessel disease: Associations with executive deficits and gait disorders via white matter injury

Neurobiology of Disease
Cerebral small vessel disease (CSVD) is a major cause of executive dysfunction and gait disturbances in older adults, with white matter injury being a key contributor.
Shujian Chen, Xianfeng Yu, Qiuju Gong, Jing Cao, Jiajia Qin, Yayu Wang, Zhongwu Sun, Xia Zhou, Xiaoqun Zhu   +8 more
doaj   +1 more source