Results 51 to 60 of about 1,362 (166)

Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community‐Dwelling Older Adults

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
DTI‐ALPS and FW‐WM significantly mediated the association between stenosis burden and baseline MMSE. Participants with both stenosis and impaired glymphatic function showed the most rapid MMSE decline and a higher risk of CDR‐SB worsening than those with stenosis but preserved glymphatic function or those without stenosis.
Weizhuang Yuan, Xingyang Niu, Linfang Lan, Xinran Chen   +3 more
wiley   +1 more source

Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis

Cancer Imaging
Background Gliomas may impair glymphatic function and alter cerebrospinal fluid (CSF) dynamics through structural brain changes, potentially affecting peritumoral brain edema (PTBE) and fluid clearance.
Weiqiang Liang, Wenbo Sun, Chunyan Li, Jie Zhou, Changyou Long, Huan Li, Dan Xu, Haibo Xu   +7 more
doaj   +1 more source

Decreased diffusivity along the perivascular spaces in bipolar disorder: an MRI-based cross-sectional and Mendelian randomization study

Translational Psychiatry
The pathophysiology of bipolar disorder (BD) remains unclear. We investigated whether diffusion tensor imaging along perivascular spaces (DTI-ALPS), a putative MRI marker of glymphatic function, is altered in BD and whether this index relates to ...
Zhuohui Chen, Ziwei Teng, Yan Qiu, Sujuan Li, Xuelei Xu, Min Yang, Jindong Chen, Dong Yang, Hao Li   +8 more
doaj   +1 more source

Evaluation of the DTI-ALPS Index as a Biomarker of the Glymphatic System at 1.5T

The Open Neuroimaging Journal
Introduction The glymphatic system is a waste clearance pathway within the brain that relies on the flow of cerebrospinal fluid facilitated by astrocytes. It has been proposed that this glymphatic system can be observed using Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS).
Irene Marín, Francisco Torres, Rodrigo Riveros, Bárbara Oliva, Joanna Vega, Carolina Saavedra, Sebastián Rojas, Matías González, Carlos Bennett, Pablo Cox, Stéren Chabert   +10 more
openaire   +1 more source

Glymphatic system dysfunction associated with cognitive impairment in chronic tinnitus patients

Frontiers in Neuroscience
BackgroundThe glymphatic system has been regarded as a pivotal factor in the pathogenesis of neurodegenerative diseases. Given the heightened risk of cognitive impairment in chronic tinnitus patients, the possible alterations of the glymphatic system in ...
Yinjuan Du, Zhichun Huang, Yuanqing Wu, Yuan Xue, Zigang Che   +4 more
doaj   +1 more source

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes

Epilepsia Open
Objective This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI‐ALPS) and to explore its correlation with clinical factors and ...
Ruotong Chen, Hong Li, Pu Miao, Hongyi Ye, Xiao Chen, Yuyu Yang, Jinqi Zhou, Yihe Chen, Yi Ge, Chenmin He, Xiaotong Shao, Zijian Wang, Yuting Gong, Cong Chen, Shan Wang, Lingli Hu, Lingqi Ye, Yao Ding, Shuang Wang, Linglin Yang   +19 more
doaj   +1 more source

Retinal microvascular changes are related to indicators of glymphatic dysfunction and small vessel disease in frontotemporal dementia

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Retinal vascular alterations have been associated with cerebral small vessel disease (SVD) in frontotemporal dementia (FTD), but their relationship with magnetic resonance imaging (MRI)‐derived glymphatic‐related diffusion markers remains unclear.
William Robert Kwapong, Yufei Chen, Xu Chen, Jiahui Hou, Hua Lu, Yuxuan Xu, Qianqian He, Yuan Gao, Ruoyu Jiao, Liyong Wu, Xuxiang Zhang, Min Chu   +11 more
wiley   +1 more source

Diffusion tensor imaging analysis along the perivascular space suggests impaired glymphatic clearance in Lewy body dementia subtypes

Alzheimer’s Research & Therapy
Background Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are subtypes of Lewy body dementia (LBD) and overlap in symptoms and pathology.
Naomi Hannaway, Angeliki Zarkali, Rohan Bhome, Ivelina Dobreva, Sabrina Kalam, George E. C. Thomas, Barbara Dymerska, Irene Gorostiaga Belio, Katie Tucker, Amanda Heslegrave, Henrik Zetterberg, Rimona S. Weil   +11 more
doaj   +1 more source

Additional Effects of 1‐Hz rTMS Combined With Tai Chi Chuan on Dual‐Task Performance Among Older Adults With Sleep Disorders and MCI: An fNIRS‐Based Randomized Controlled Trial

Brain and Behavior, Volume 16, Issue 9, September 2026.
1‐Hz rTMS enhances Tai Chi–induced improvements in dual‐task performance in older adults with sleep disorders and MCI, potentially via increased activation and functional connectivity within prefrontal and premotor regions. ABSTRACT Objective This study aimed to determine whether 1‐Hz repetitive transcranial magnetic stimulation (rTMS) combined with ...
Zhenxing Guo, Kaifeng Xu, Linxin Bai, Yuxuan Sun, Lin Zhang, Jiahui Gao, Lidian Chen, Zhizhen Liu   +7 more
wiley   +1 more source

Glymphatic dysfunction assessed by DTI-ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study

Frontiers in Neurology
BackgroundThe glymphatic system (GS), responsible for clearing neurotoxic proteins (such as β-amyloid and tau protein), is critical in stroke pathophysiology. However, its role in acute post-stroke cognitive impairment (PSCI) remains unclear.
Yirong Wang, Mei Yang, Xingmao Zeng, Shuai Wang, Wenmin Zhang, Weidong Wang, Yang Du, Jurong Ding, Xin Ding   +8 more
doaj   +1 more source