Results 1 to 10 of about 6,124,437 (230)

Glymphatic clearance function in patients with cerebral small vessel disease

NeuroImage, 2021
Few studies have focused on the connection between glymphatic dysfunction and cerebral small vessel disease (CSVD), partially due to the lack of non-invasive methods to measure glymphatic function. We established modified index for diffusion tensor image
Wenhua Zhang, Ying Zhou, Jianan Wang, Xiaoxian Gong, Zhicai Chen, Xuting Zhang, Jinsong Cai, Siyan Chen, Lei Fang, Jianzhong Sun, Min Lou   +10 more
doaj   +7 more sources

Measuring glymphatic function: Assessing the toolkit [PDF]

Neural Regeneration Research
Glymphatic flow has been proposed to clear brain waste while we sleep. Cerebrospinal fluid moves from periarterial to perivenous spaces through the parenchyma, with subsequent cerebrospinal fluid drainage to dural lymphatics.
Koushikk Ayyappan, Lucas Unger, Philip Kitchen, Roslyn M. Bill, Mootaz M. Salman   +4 more
doaj   +6 more sources

Cholinergic basal forebrain modulation of glymphatic function: implications for depression [PDF]

Translational Psychiatry
Emerging evidence links glymphatic dysfunction to depression, yet its regulatory mechanisms remain unclear. Through multimodal neuroimaging of two independent cohorts, we tested the hypothesis that the cholinergic basal forebrain (ChBF) modulates ...
Yirong Fang, Zeyu Lu, Xian Chao, Ran Shi, Dawei Yin, Yanan Lu, Peng Wang, Xinfeng Liu, Wen Sun   +8 more
doaj   +4 more sources

AQP4-dependent enhancement of glymphatic function attenuates tau pathology and neurodegeneration in PS19 mice [PDF]

Molecular Neurodegeneration
Background The glymphatic system facilitates cerebrospinal fluid–interstitial fluid exchange and contributes to the clearance of pathogenic proteins from the brain.
Kaoru Yamada, Kazuhisa Ishida, Asami Sakamoto, Hitoshi Shimada, Masaki Watanabe, Masato Shimojo, Hironaka Igarashi, Takeshi Iwatsubo   +7 more
doaj   +3 more sources

Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease [PDF]

Frontiers in Neurology
IntroductionCognitive impairment ties to neurovascular coupling (NVC) dysfunction, which may interact with the glymphatic pathway. This study examined the relationships between NVC, glymphatic clearance, and cognitive function in asymptomatic cerebral ...
Jing Chen, Yifu Wang, Xing Chen, Caizhong Chen, Wenbin Shi, Jing Ding   +5 more
doaj   +3 more sources

Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS [PDF]

Frontiers in Neuroscience
The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired glymphatic function leads to the deposition of metabolic waste products in the brain potentially ...
Kiran Thapaliya, Sonya Marshall-Gradisnik, Maira Inderyas, Leighton Barnden   +3 more
doaj   +2 more sources

PDGF-B Is Required for Development of the Glymphatic System

Cell Reports, 2019
Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways.
Anne Sofie Munk, Wei Wang, Nicholas Burdon Bèchet, Ahmed M. Eltanahy, Anne Xiaoan Cheng, Björn Sigurdsson, Abdellatif Benraiss, Maarja A. Mäe, Benjamin Travis Kress, Douglas H. Kelley, Christer Betsholtz, Kjeld Møllgård, Anja Meissner, Maiken Nedergaard, Iben Lundgaard   +14 more
doaj   +3 more sources

Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson’s disease

Journal of Advanced Research
Introduction: The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions.
Xiaoli Si, Shaobing Dai, Yi Fang, Jiahui Tang, Zhiyun Wang, Yaolin Li, Zhe Song, Ying Chen, Yi Liu, Guohua Zhao, Baorong Zhang, Jiali Pu   +11 more
doaj   +3 more sources

Altered Glymphatic System in Middle-Aged cART-Treated Patients With HIV: A Diffusion Tensor Imaging Study

Frontiers in Neurology, 2022
Objective:The brain relies on the glymphatic system to clear metabolic wastes and maintain brain homeostasis to fulfill its functions better. Yet, the complexity of the glymphatic flow and clearance and its changes in HIV infection and its role in ...
Benedictor Alexander Nguchu, Jing Zhao, Jing Zhao, Yanming Wang, Jean de Dieu Uwisengeyimana, Xiaoxiao Wang, Bensheng Qiu, Hongjun Li, Hongjun Li   +8 more
doaj   +1 more source

Can meditation-based approaches improve the cleansing power of the glymphatic system?

Exploration of Neuroprotective Therapy, 2022
The glymphatic system, first described in 2012, is a brain-wide perivascular network that plays an important role in promoting interstitial metabolic waste removal from the brain.
Peter Wostyn, Piet Goddaer
doaj   +1 more source