Results 11 to 20 of about 6,124,437 (230)

Impaired glymphatic function in idiopathic intracranial hypertension [PDF]

Brain Communications, 2021
Abstract Idiopathic intracranial hypertension is a brain disease incorporating cerebrospinal fluid disturbance, increased intracranial pressure and visual failure, but with unknown cause. This study examined a hypothesis that glymphatic function is impaired in idiopathic intracranial hypertension patients.
Per Kristian Eide, Are Hugo Pripp, Geir Ringstad, Lars Magnus Valnes   +3 more
core   +6 more sources

Glymphatic System Function in Patients with Transient Global Amnesia

Journal of Integrative Neuroscience, 2022
Background: The purpose of this study was to examine glymphatic system function in patients with transient global amnesia (TGA), as well as to conduct a recurrence analysis. Methods: We enrolled patients with TGA and healthy controls from our hospital retrospectively.
Dong Ah Lee, Bong Soo Park, Sihyung Park, Yoo Jin Lee, Junghae Ko, Kang Min Park   +5 more
openaire   +4 more sources

Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

Translational Neurodegeneration, 2022
Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in the course of ...
Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O’Brien, David K. Wright   +6 more
doaj   +2 more sources

Effect of glymphatic system function on cognitive function in patients with chronic kidney disease [PDF]

Frontiers in Neurology
ObjectivesStudies have recently shown an alteration of the structural connectivity and a dysfunctional glymphatic system in patients with chronic kidney disease (CKD). In this study, we aimed to investigate the effects of the structural connectivity and glymphatic system on the cognitive function of patients with CKD.MethodsWe prospectively enrolled ...
Junghae Ko, Bong Soo Park, Chang Min Heo, Jiyae Yi, Dong Ah Lee, Kang Min Park   +5 more
openaire   +4 more sources

NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury

Journal of Nanobiotechnology
The glymphatic system plays an important role in the transportation of cerebrospinal fluid (CSF) and the clearance of metabolite waste in brain. However, current imaging modalities for studying the glymphatic system are limited.
Bin Sun, Danlan Fang, Wenzhong Li, Mengfei Li, Shoujun Zhu   +4 more
doaj   +2 more sources

Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review [PDF]

Frontiers in Neuroscience
IntroductionPrevious studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health.
Tilda Pihala, Vesa Kiviniemi, Vesa Kiviniemi, Vesa Kiviniemi, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen   +7 more
doaj   +2 more sources

Glymphatic Dysfunction Mediates the Influence of White Matter Hyperintensities on Episodic Memory in Cerebral Small Vessel Disease

Brain Sciences, 2022
Glymphatic dysfunction has been linked to cognitive decline in several neurodegenerative diseases. In cerebral small vessel disease (CSVD), the mechanism of white matter hyperintensities (WMH)-related cognitive impairment (CI) is still under ...
Zhihong Ke, Yuting Mo, Jiangnan Li, Dan Yang, Lili Huang, Zhiyuan Yang, Ruomeng Qin, Chenglu Mao, Weiping Lv, Yanan Huang, Zheqi Hu, Bing Zhang, Yun Xu   +12 more
doaj   +2 more sources

Glymphatic influx and clearance are perturbed in Huntington’s disease

JCI Insight
The accumulation of mutant huntingtin protein aggregates in neurons is a pathological hallmark of Huntington’s disease (HD). The glymphatic system, a brain-wide perivascular network, facilitates the exchange of interstitial fluid and cerebrospinal fluid (
Hongshuai Liu, Lin Chen, Chuangchuang Zhang, Chang Liu, Yuguo Li, Liam Cheng, Yuxiao Ouyang, Catherine Rutledge, John Anderson, Zhiliang Wei, Ziqin Zhang, Hanzhang Lu, Peter C.M. van Zijl, Jeffrey J. Iliff, Jiadi Xu, Wenzhen Duan   +15 more
doaj   +2 more sources

Continuous positive airway pressure increases CSF flow and glymphatic transport [PDF]

JCI Insight, 2023
Respiration can positively influence cerebrospinal fluid (CSF) flow in the brain, yet its effects on central nervous system (CNS) fluid homeostasis, including waste clearance function via glymphatic and meningeal lymphatic systems, remain unclear.
Burhan Ozturk, Sunil Koundal, Ehab Al Bizri, Xinan Chen, Zachary Gursky, Feng Dai, Andrew Lim, Paul Heerdt, Jonathan Kipnis, Allen Tannenbaum, Hedok Lee, Helene Benveniste   +11 more
doaj   +2 more sources

Thalamic volume alterations mediate glymphatic function and cognitive dysfunction in Alzheimer's disease. [PDF]

Alzheimers Dement (N Y)
INTRODUCTION Glymphatic dysfunction is implicated in Alzheimer's disease (AD), but its mechanism remains unclear. This study investigated the associations of the analysis along the perivascular space (ALPS) index, brain reserve, and ...
Chen L, Zhou X, Zhang B, Hou Y, Sun Y, Peng D, Alzheimer's Disease Neuroimaging Initiative (ADNI).   +6 more
europepmc   +2 more sources