Results 21 to 30 of about 6,124,437 (230)

Does G-ALPS measure glymphatic function? Revisiting construct validity in diffusion-based glymphatic imaging. [PDF]

Alzheimers Dement
Camargos EF, Olegário RL, Nóbrega OT.
europepmc   +3 more sources

The Sleep Puzzle: Linking Glymphatic Function to Cognitive Decline. [PDF]

Eur J Neurol
Non peer ...
Ahlström ME, Sihvonen AJ.
europepmc   +4 more sources

Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson’s disease

npj Parkinson's Disease
Glymphatic dysfunction potentially contributes to Parkinson’s disease (PD) via impaired clearance of metabolic waste products. Obstructive sleep apnea (OSA) can disturb sleep, which is necessary for proper glymphatic function, and is frequent in PD.
Jiri Nepozitek, Stanislav Marecek, Veronika Rottova, Simona Dostalova, Tomas Krajca, Jiri Keller, Karel Sonka, Petr Dusek   +7 more
doaj   +2 more sources

Surgery impairs glymphatic activity and cognitive function in aged mice

Molecular Brain
Delirium is a common complication in elderly surgical patients and is associated with an increased risk of dementia. Although advanced age is a major risk factor, the mechanisms underlying postoperative delirium remain poorly understood.
Kai Chen, Xingyu Du, Melissa A. Chao, Zhongcong Xie, Guang Yang   +4 more
doaj   +3 more sources

Glymphatic System in Adolescents with Major Depressive Disorder: No Dysfunction and No Association with Poor Sleep Quality [PDF]

Nature and Science of Sleep
Jie Zhang,1 Xingxiong Zou,1 Xianjie Cai,2 Menghong Zou,1 Hongwei Li,1 Ruohan Feng1 1Department of Radiology, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang Sichuan, 621000, People’s Republic of China; 2Department of Radiology, MOE
Zhang J, Zou X, Cai X, Zou M, Li H, Feng R   +5 more
doaj   +1 more source

Glymphatic function in the gyrencephalic brain [PDF]

, 2020
ABSTRACT Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta.
Nicholas Burdon Bèchet, Nagesh C. Shanbhag, Iben Lundgaard   +2 more
openaire   +1 more source

Dysfunction of the Glymphatic System as a Potential Mechanism of Perioperative Neurocognitive Disorders

Frontiers in Aging Neuroscience, 2021
Perioperative neurocognitive disorder (PND) frequently occurs in the elderly as a severe postoperative complication and is characterized by a decline in cognitive function that impairs memory, attention, and other cognitive domains.
Xuli Ren, Shan Liu, Chuang Lian, Haixia Li, Kai Li, Longyun Li, Guoqing Zhao, Guoqing Zhao   +7 more
doaj   +1 more source

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

eLife, 2023
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately establishing directional clearance of interstitial solutes.
Ryszard Stefan Gomolka, Lauren M Hablitz, Humberto Mestre, Michael Giannetto, Ting Du, Natalie Linea Hauglund, Lulu Xie, Weiguo Peng, Paula Melero Martinez, Maiken Nedergaard, Yuki Mori   +10 more
doaj   +1 more source

Physical exercise as a non-pharmacological strategy to enhance glymphatic function. [PDF]

IBRO Neurosci Rep
The glymphatic system plays a critical role in clearing metabolic waste and neurotoxic proteins from the brain, and its dysfunction is implicated in neurodegenerative diseases such as Alzheimer's disease (AD). Emerging evidence indicates that physical exercise enhances glymphatic function through multiple mechanisms, including increased cerebrospinal ...
Ghayourvahdat A, Azimizonuzi H, Ahmed M.
europepmc   +4 more sources

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics [PDF]

Journal of Clinical Investigation, 2017
Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here, we summarize the state of the field and point out the gaps of knowledge that should be filled through further research.
Louveau, Antoine, Plog, Benjamin A., Antila, Salli, Alitalo, Kari, Nedergaard, Maiken, Kipnis, Jonathan   +5 more
openaire   +4 more sources