Results 41 to 50 of about 6,124,437 (230)

Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study. [PDF]

IBRO Neurosci Rep
Zhang Y, Sun J, Guo S, Hui Y, Li X, Li J, Zhao X, Zhao P, Chen S, Wu S, Wang Z, Lv H.   +11 more
europepmc   +2 more sources

Impaired Glymphatic Function in Acute Spontaneous Intracerebral Hemorrhage. [PDF]

CNS Neurosci Ther
ABSTRACT Background and Aims Alterations in glymphatic function during the acute phase of acute spontaneous intracerebral hemorrhage (sICH) remain poorly understood. The aim of this study was to investigate whether, compared to healthy controls (HCs), the glymphatic system is impaired in ...
Cai J, Dong Y, Fang M, Wei K, Yan S, Zhou Y.   +5 more
europepmc   +3 more sources

Influencing factors of glymphatic system during perioperative period

Frontiers in Neuroscience
The glymphatic system is a functional cerebrospinal fluid circulatory system that uses peri-arterial space for inflow of cerebrospinal fluid and peri-venous space for efflux of cerebrospinal fluid from brain parenchyma.
Rui Dong, Rui Dong, Rui Dong, Wenjie Liu, Yuqiang Han, Zimo Wang, Linhao Jiang, Liwei Wang, Xiaoping Gu   +8 more
doaj   +1 more source

Exercise as a regulator of glymphatic function

Trends in Neurosciences
The glymphatic system is a brain-wide perivascular network hypothesized to facilitate the clearance of waste products that accumulate during normal brain activity, including neurotoxic proteins implicated in neurodegenerative diseases. Emerging evidence suggests that exercise may modulate glymphatic function, offering a potential mechanism to help ...
James R. Broatch, Nicholas J. Saner, Melinda L. Jackson, Warda Syeda, David J. Bishop, Amy Brodtmann   +5 more
openaire   +2 more sources

Mapping the Glymphatic Pathway Using Imaging Advances

, 2023
The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e ...
Pratiksha Sharma, Ivelina P. Kioutchoukova, Rajvi N. Thakkar, Eduardo Molina Valero, Ian Griffin, Devon T. Foster, Brandon Lucke-Wold   +6 more
core   +1 more source

Glymphatic dysfunction and neurodegeneration in ALS: Longitudinal insights from rNLS8 TDP-43 mice

Neurobiology of Disease
Dysfunctional Tar DNA binding protein-43 (TDP-43) is found in approximately 95 % of all people with amyotrophic lateral sclerosis (ALS). Recent evidence suggests that the glymphatic system, which clears the brain of waste proteins, is impaired in ALS and
Akram Zamani, Adam K. Walker, David K. Wright   +2 more
doaj   +1 more source

Data_Sheet_1_Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment.PDF

, 2022
Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) leads to
Jeffrey J. Iliff (11808058), Akihiro Kitamura (356907), Roxana O. Carare (6914390), Rajesh N. Kalaria (11940602), Joshua Beverley (11940584), Ulrich K. Wiegand (11940599), Bettina Platt (196795), Mosi Li (11940581), Karen Horsburgh (518892), Maurits A. Jansen (11940596), Ross Lennen (11940593), Jessica Duncombe (11940590), Ian Marshall (287669), Juraj Koudelka (11940587)   +13 more
core   +1 more source

Functional abnormalities of the glymphatic system in cognitive disorders

Neural Regeneration Research
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders.
Wuyue Shentu, Qi Kong, Yier Zhang, Wenyao Li, Qiulu Chen, Sicheng Yan, Junjun Wang, Qilun Lai, Qi Xu, Song Qiao   +9 more
openaire   +3 more sources

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study

Neurobiology of Disease
Background: Emerging evidence implicating glymphatic dysfunction contributes to the pathogenesis of frontotemporal dementia (FTD). However, the pathway correlated to glymphatic function in FTD remains poorly understood.
Min Chu, Ailing Yue, Haitian Nan, Hong Ye, Miao Qu, Liyong Wu   +5 more
doaj   +1 more source