Results 41 to 50 of about 1,362 (166)

Glymphatic dysfunction across sleep disorders: a meta-analysis of DTI-ALPS studies. [PDF]

Front Neurol
Background Sleep disorders are increasingly linked to glymphatic dysfunction, but whether this impairment is universal across different sleep pathologies remains unclear. Objective This meta-analysis examined whether glymphatic ...
Zhang X, He D.
europepmc   +2 more sources

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre, Yukti Vyas, Angela L. Jefferson   +2 more
wiley   +1 more source

Assessment of the glymphatic dysfunction in amyotrophic lateral sclerosis using the diffusion tensor imaging along the perivascular spaces index: a pilot study

Frontiers in Aging Neuroscience
BackgroundThe glymphatic system plays a critical role in clearing interstitial waste from the brain. Dysfunction of this system has been linked to various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).
Seol-Hee Baek, Woo-Suk Tae, Jin-Woo Park, Byung-Jo Kim, Byung-Jo Kim   +4 more
doaj   +1 more source

MRI‐derived glymphatic‐related composite captures brain and cognitive vulnerability associated with cardiovascular risk in older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We evaluated a multimodal magnetic resonance imaging (MRI)‐derived glymphatic‐related composite and examined its associations with cardiovascular risk, brain structural integrity, and cognition in older adults. METHODS Ninety‐two participants were included in the baseline analyses and 68 in the 6‐month reassessment analyses ...
Zhan Wang, Guojun Lin, Fang Fang, Jing Yu   +3 more
wiley   +1 more source

DTI-ALPS index decreased in patients with Type 2 Diabetes Mellitus

Frontiers in Neuroscience
BackgroundsType 2 Diabetes Mellitus (T2DM) has become a significant global public health issue, characterized by a rising prevalence and associated deficits across multiple organ systems. Our study aims to utilize the DTI-ALPS technique to assess the change of ALPS index in T2DM patients, and to explore whether such changes are correlated with ...
Shuncheng Yu, Hongjun Jiang, Langxuan Yu, Tieli Liu, Chun Yang, Jiajun Cao, Qingwei Song, Yanwei Miao, Weiwei Wang   +8 more
openaire   +3 more sources

Association of Glymphatic Imaging Markers With Clinical Outcomes and Cerebral Small Vessel Disease Burden After Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 10, October 2026.
In patients with intracerebral hemorrhage, higher free water fraction in contralateral white matter was associated with lower odds of functional independence and greater WMH burden. These associations did not remain statistically significant after FDR correction, and the FW–outcome association was nonsignificant after adjustment for WMH burden ...
Xiao Hu, Zuoqiao Li, Zijie Wang, Yingmei Zhang, Mengqiu Zhang, Sijia Liu, Fan Chen, Jianshuo Shao, Longsheng Wang, Qi Li   +9 more
wiley   +1 more source

Orientation-Aware Refinement of the DTI-ALPS Index

The diffusion tensor imaging along perivascular spaces (DTI-ALPS) index is a non-invasive marker related to perivascular diffusion, but its reliance on fixed scanner-aligned axes makes it sensitive to head tilt and anatomical variability. We describe a refinement that computes directional diffusivities along subject-specific axes derived from tract ...
Hwang, Scott, Jones, Gavin, Mubin, Numa, Quillen, Jack, Kanekar, Sangam   +4 more
openaire   +1 more source

DTI-ALPS index as a predictor of glymphatic system dysfunction in cerebral infarction

American Journal of Translational Research
To evaluate glymphatic system (GS) dysfunction in patients with cerebral infarction using diffusion tensor imaging - along the perivascular space (DTI-ALPS), and to investigate factors associated with glymphatic function impairment following stroke.A retrospective study was conducted on 82 patients diagnosed with cerebral infarction at Zhujiang ...
Bomiao, Lin, Yuh Yang, Leong, Mazlyfarina, Mohamad   +2 more
openaire   +2 more sources

Magnetic Resonance Imaging in Cerebral Small Vessel Disease‐Related Depression: From Visual Scoring to Artificial Intelligence

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Starting with MRI data acquisition, it presents the core steps and outputs of visual scoring, traditional machine learning, and deep learning along three evolving paths, and integrates them into the clinical application direction, illustrating the technological evolution from qualitative description to precise prediction.
Chaofang Lei, Jiaxu Chen, Yilong Wang
wiley   +1 more source

Altered brain glymphatic function on diffusion-tensor MRI in patients with spontaneous intracerebral hemorrhage: an exploratory study

Frontiers in Aging Neuroscience
ObjectivesTo investigate the function of the glymphatic system (GS) and its association with neuropsychological tests in spontaneous intracerebral hemorrhage (sICH) by diffusion tensor imaging analysis along the perivascular space (DTI-ALPS).MethodsThis ...
Xiaona Xia, Qingguo Ren, Juntao Zhang, Shuai Guan, Qingjun Jiang, Ying Wei, Rui Hua, Shen Zhao, Xiangjun Hu, Xiangjun Hu, Feng Shi, Xiangshui Meng   +11 more
doaj   +1 more source