Results 21 to 30 of about 1,362 (166)

Evaluation of the Glymphatic System Using the DTI‐ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage

Oxidative Medicine and Cellular Longevity, 2022
Objective. To investigate the function of the human glymphatic system (GS) in patients with spontaneous intracerebral haemorrhage (sICH) using diffusion tensor imaging analysis along with the perivascular space (DTI‐ALPS). Methods. Twenty patients with sICH and 31 healthy controls (HCs) were recruited for DTI and susceptibility‐weighted imaging ...
Chao Zhang, Jingyun Sha, Lulu Cai, Yingying Xia, Danyang Li, Houliang Zhao, Chong Meng, Kai Xu   +7 more
openaire   +2 more sources

APOE4 modulates the association between DTI-ALPS index and Alzheimer's pathologies. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Diffusion‐tensor imaging (DTI) analysis along the perivascular space (ALPS) has emerged as a non‐invasive marker of glymphatic function. Preclinical studies suggest that apolipoprotein E4 ( APOE 4), a major
Kang KM, Park C, Byun MS, Yi D, Nam H, Ryu J, Jung JH, Jung G, Ahn H, Lee JY, Lee YS, Kim YK, Sohn CH, Lee DY, KBASE Research Group.   +14 more
europepmc   +3 more sources

Association of glymphatic clearance function with imaging markers and risk factors of cerebral small vessel disease

Journal of Stroke and Cerebrovascular Diseases
Background: Cerebral small vessel disease (CSVD) is a common disease in the elderly, and its pathogenesis is still being explored. Glymphatic clearance function can be evaluated by diffusion tensor imaging analysis along the perivascular space (DTI-ALPS)
Jie Yang, Yujian Liu, Yuanying Ma, Wei Zhang, Limei Han, Hao Feng, Meining Chen, Jianquan Zhong   +7 more
doaj   +1 more source

Altered perivascular-aligned diffusivity in postherpetic neuralgia assessed by the DTI-ALPS index. [PDF]

Front Neurosci
Background The glymphatic system has been proposed as a key pathway for interstitial fluid clearance in the brain, but its role in chronic neuropathic pain conditions such as postherpetic neuralgia (PHN) remains unclear.
Oh D, Lee DA, Lee HJ, Lee HS, Park KM.
europepmc   +2 more sources

Glymphatic system dysfunction in children with autism spectrum disorder as evidenced by the diffusion tensor imaging along perivascular spaces index

Frontiers in Psychiatry
IntroductionThis study aims to evaluate glymphatic system function in autism spectrum disorder (ASD) by employing diffusion tensor imaging along perivascular spaces (DTI-ALPS), and investigate its relationship with visual-motor integration (VMI) function.
Shengnan Zhao, Manxue Zhang, Tingting Luo, Lei Li, Yuchu Jiang, Mingjing Situ, Yi Huang, Yi Huang, Yi Huang   +8 more
doaj   +1 more source

Changes in the glymphatic system before and after dialysis initiation in patients with end-stage kidney disease

Renal Failure, 2023
Introduction The aims of this study were to evaluate 1) glymphatic system function in patients with end-stage kidney disease (ESKD) before initiating dialysis compared to healthy controls, and 2) changes in the glymphatic system function after kidney ...
Yoo Jin Lee, Kang Min Park, Chang Min Heo, Sihyung Park, Yang Wook Kim, Dongyeol Lee, Yunmi Kim, Joon Seok Oh, Ho Sik Shin, Bong Soo Park   +9 more
doaj   +1 more source

Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates. [PDF]

J Neurooncol
Abstract Purpose: Glioblastoma is an aggressive primary brain tumor that often exhibits perivascular invasion. This behavior may directly interfere with glymphatic flow, hindering perivascular drainage routes. This study aims to assess glymphatic dysfunction in glioblastoma by evaluating the DTI-ALPS index, an MRI ...
Nath B, Bobholz SA, Kim DC, Lowman AK, Duenweg SR, Winiarz A, Chao B, Kyereme F, Barrett M, Reecher HM, Connelly J, Mrachek EKS, Jacobsohn J, Krucoff MO, Tanhehco E, Agarwal M, Destiche D, Banerjee A, LaViolette PS.   +18 more
europepmc   +5 more sources

Association of reduced DTI-ALPS index and increased free water with glymphatic system alterations in noise-induced hearing loss: a neuroimaging study

Scientific Reports
To investigate diffusion changes suggestive of possible glymphatic alterations in patients with noise-induced hearing loss (NIHL), and to evaluate their relationships with free water (FW) and clinical characteristics. DTI scans were acquired from 48 NIHL
Liping Wang, Wei Lian, Ranran Huang, Aijie Wang, Minghui Lv, Xinyao Zhao, Zengcai Zhang, Guowei Zhang   +7 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Radiation-induced glymphatic dysfunction in patients with nasopharyngeal carcinoma: a study using diffusion tensor image analysis along the perivascular space

Frontiers in Neuroscience
Radiation encephalopathy (RE) refers to radiation-induced brain necrosis and is a life-threatening complication in patients with nasopharyngeal carcinoma (NPC) after radiotherapy (RT), and radiation-induced pre-symptomatic glymphatic alterations have not
Xingyou Zheng, Jianchun Peng, Qing Zhao, Qing Zhao, Li Li, Jian-ming Gao, Keyang Zhou, Bei Tan, Lingling Deng, Youming Zhang, Youming Zhang   +10 more
doaj   +1 more source