Results 11 to 20 of about 1,362 (166)

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Frontiers in Neuroscience, 2023
PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated.
Yue Qin, Yue Qin, Xin Li, Yanqiang Qiao, Yanqiang Qiao, Huili Zou, Yifan Qian, Xiaoshi Li, Yinhu Zhu, Wenli Huo, Lei Wang, Lei Wang, Ming Zhang   +12 more
doaj   +3 more sources

Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function

Frontiers in Neurology
Recent studies suggest that glymphatic dysfunction plays a significant role in vascular cognitive impairment (VCI). Both hypertension and hyperhomocysteinemia are independent risk factors for VCI, and their combination is referred to as H-type ...
Chun Zhang, Chun Zhang, Caihong Song, Shiying Sheng, Liang Pan, Lingling Sun, Wei Xing   +6 more
doaj   +3 more sources

Glymphatic System Assessment Using DTI-ALPS in Age-Dependent Neurodegenerative Diseases [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Dysfunction of the glymphatic system glymphatic system of the brain is considered a pathogenetic factor in some age-dependent neurodegenerative diseases, including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson's ...
Alina A. Liaskovik, Rodion N. Konovalov, Yulia A. Shpilyukova, Kseniya V. Nevzorova, Anna N. Moskalenko, Ekaterina Yu. Fedotova, Marina V. Krotenkova   +6 more
doaj   +2 more sources

Glymphatic System Dysfunction and its Associated Factors in Wilson's Disease: A DTI-ALPS Study. [PDF]

Brain Behav
Glymphatic function, assessed by DTI‐ALPS index, was impaired in neurological Wilson's disease compared with hepatic phenotype and controls. Age, AST, and UWDRS‐I score independently predicted dysfunction, linking neurodegeneration, liver injury, and altered glymphatic activity. ABSTRACT Background Wilson's disease (WD) is a genetic disorder of copper (
Zhu L, Wu T, Zhang LJ, Liu QY, Zhang LL, Song B, Zhu YL, Hua L, Zhang L, Li B, Sun Q, Xue BC, Xu Y, Han YZ, Han YS.   +14 more
europepmc   +2 more sources

Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome‐wide association datasets for three DTI‐ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR ...
Zhou H, Deng J, Wu Q, Zeng Y, Wang T, Wu J, Duan X, Tang B, Wei X, He L, Liu F.   +10 more
europepmc   +2 more sources

DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study. [PDF]

Hum Brain Mapp
A higher DTI‐derived ALPS index relates cross‐sectionally to both quantitative and visual measures of SVD and is associated with short‐term amyloid‐β accumulation in cognitively normal older adults. Also, greater amyloid burden and choroid plexus volume are associated with a more rapid deterioration in global cognition and processing speed.
Azizi N, Borooghani H, Kiani I, Gharaylou Z, Seyedi D, Firouznia K, Kolahi S.   +6 more
europepmc   +2 more sources

DTI-ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi-Modal MRI. [PDF]

Hum Brain Mapp
In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...
Sacchi L, Farruggio G, Bocca G, Carandini T, De Riz M, Ghezzi L, Pintus M, Pietroboni A, Boffa G, Scola E, Triulzi F, Bozzali M, Galimberti D, Cercignani M, Arighi A.   +14 more
europepmc   +2 more sources

Polysomnographic findings and DTI‐ALPS in Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Sleep disorders are common comorbid pathology in patients with Alzheimer's disease (AD). It is generally accepted that sleep disorders may be a risk factor for AD development due to increased Aβ deposition in the brain and may contribute to more rapid progression of ...
Brsikyan L, Vasileva E, Nevzorova K, Sergeeva A, Krotenkova M, Broutian A, Fedotova E, Illarioshkin S.   +7 more
europepmc   +2 more sources

Glymphatic system dysfunction in patients with cluster headache

Brain and Behavior, 2022
Introduction The aim of this study was to investigate alterations of the glymphatic system function in patients with cluster headache. Methods We enrolled patients with cluster headache and healthy controls, and they underwent brain magnetic resonance ...
Jinseung Kim, Dong Ah Lee, Ho‐Joon Lee, Bong Soo Park, Junghae Ko, Si Hyung Park, Yoo Jin Lee, Il Hwan Kim, Jin Han Park, Kang Min Park   +9 more
doaj   +1 more source

Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson’s disease

npj Parkinson's Disease, 2022
The brain glymphatic system is involved in the clearance of misfolding α-synuclein, the impaired glymphatic system may contribute to the progression of Parkinson’s disease (PD). We aimed to analyze the diffusion tensor image along the perivascular space (
Ting Shen, Yumei Yue, Fang Ba, Tinging He, Xiaocui Tang, Xingyue Hu, Jiali Pu, Cong Huang, Wen Lv, Baorong Zhang, Hsin-Yi Lai   +10 more
doaj   +1 more source