Results 31 to 40 of about 1,362 (166)

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Glymphatic system dysfunction in nondialysis-dependent ESRD patients with diabetic kidney disease: associations with clinical characteristics and cognitive function

Renal Failure
Objectives To investigate glymphatic function in nondialysis-dependent ESRD (ND-ESRD) patients with diabetic kidney disease (DKD) or non-DKD using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus (CP ...
Bingxin Yu, Wenbo Yang, Lijun Song, Mingan Li, Boyan Xu, Zhenchang Wang, Zongli Diao, Hao Wang   +7 more
doaj   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Cognitive function changes and DTI-ALPS index in postmenopausal women

Frontiers in Aging Neuroscience
BackgroundCognitive decline in postmenopausal women is a growing public health concern, with estrogen deficiency linked to brain aging. However, the role of the brain's lymphatic-like system—assessed via the diffusion tensor imaging along the perivascular space (DTI-ALPS) index—in mediating estrogen-cognitive associations remains unclear.
Ningning Liu, Yue Zhang, Weiqing Fu, Huijun Liu   +3 more
openaire   +3 more sources

Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor

Frontiers in Aging Neuroscience
BackgroundPerivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural ...
Zhiming Zeng, Zhiming Zeng, Xin Jia, Xin Jia, Shushu Han, Cuidie Zeng, Cuidie Zeng, Jing Bi, Jing Bi, Lingchen Liu, Lingchen Liu, Yueming Wu, Yueming Wu, Tengao Gao, Tengao Gao, Lei Liang, Fangxiao Cheng, Fangxiao Cheng   +17 more
doaj   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Characteristics of brain glymphatic system changes in patients with amnestic mild cognitive impairment based on perivascular spaces and DTI-ALPS index assessment

Zhongguo Linchuang Yixue
ObjectiveTo explore the characteristics and correlation between perivascular spaces (PVS) and diffusion tensor image analysis along perivascular spaces (DTI-ALPS) index in patients with amnestic mild cognitive impairment (aMCI).
Xiaoqin Cheng, Guoqiang Fei, Shen Zhao, Rui Hua, Feng Shi, Xiaoli Pan, Ziyi He, Sirui Liu   +7 more
doaj   +1 more source

Repetitive transcranial magnetic stimulation promotes the recovery of upper limb motor dysfunction in ischemic stroke patients: a DTI-based glymphatic system imaging prospective study [PDF]

PeerJ
Background Repetitive transcranial magnetic stimulation (rTMS) is an effective tool for motor function recovery in patients with ischemic stroke (IS). Dysfunction of the glymphatic system is implicated in the pathological process of IS.
Yulan Dong, Jing Liu, Tianyao Wang, Zhaoxiang Zhang, Xiaoyue Hu, Chengjia Zhu, Meijuan Gao, Ping Yan, Hao Lei, Jun Zhou   +9 more
doaj   +2 more sources

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, Volume 100, Issue 5, Page 1055-1067, November 2026.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source